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Calcium intake and hip fracture risk in men and women: a meta-analysis of prospective cohort studies and randomized controlled trials.
Am J Clin Nutr 2007; 86(6):1780-90AJ

Abstract

BACKGROUND

The role of total calcium intake in the prevention of hip fracture risk has not been well established.

OBJECTIVE

The objective of the study was to assess the relation of calcium intake to the risk of hip fracture on the basis of meta-analyses of cohort studies and clinical trials.

RESULTS

In women (7 prospective cohort studies, 170,991 women, 2,954 hip fractures), there was no association between total calcium intake and hip fracture risk [pooled risk ratio (RR) per 300 mg total Ca/d = 1.01; 95% CI: 0.97, 1.05]. In men (5 prospective cohort studies, 68,606 men, 214 hip fractures), the pooled RR per 300 mg total Ca/d was 0.92 (95% CI: 0.82, 1.03). On the basis of 5 clinical trials (n = 5666 women, primarily postmenopausal, plus 1074 men) with 814 nonvertebral fractures, the pooled RR for nonvertebral fractures between calcium supplementation (800-1600 mg/d) and placebo was 0.92 (95% CI: 0.81, 1.05). On the basis of 4 clinical trials with separate results for hip fracture (6,504 subjects with 139 hip fractures), the pooled RR between calcium and placebo was 1.64 (95% CI:1.02, 2.64). Sensitivity analyses including 2 additional small trials with <100 participants or per-protocol results did not substantially alter results.

CONCLUSIONS

Pooled results from prospective cohort studies suggest that calcium intake is not significantly associated with hip fracture risk in women or men. Pooled results from randomized controlled trials show no reduction in hip fracture risk with calcium supplementation, and an increased risk is possible. For any nonvertebral fractures, there was a neutral effect in the randomized trials.

Authors+Show Affiliations

Department of Nutrition, Harvard School of Public Health, Boston, MA, USA. heike.bischoff@usz.chNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18065599

Citation

Bischoff-Ferrari, Heike A., et al. "Calcium Intake and Hip Fracture Risk in Men and Women: a Meta-analysis of Prospective Cohort Studies and Randomized Controlled Trials." The American Journal of Clinical Nutrition, vol. 86, no. 6, 2007, pp. 1780-90.
Bischoff-Ferrari HA, Dawson-Hughes B, Baron JA, et al. Calcium intake and hip fracture risk in men and women: a meta-analysis of prospective cohort studies and randomized controlled trials. Am J Clin Nutr. 2007;86(6):1780-90.
Bischoff-Ferrari, H. A., Dawson-Hughes, B., Baron, J. A., Burckhardt, P., Li, R., Spiegelman, D., ... Willett, W. C. (2007). Calcium intake and hip fracture risk in men and women: a meta-analysis of prospective cohort studies and randomized controlled trials. The American Journal of Clinical Nutrition, 86(6), pp. 1780-90.
Bischoff-Ferrari HA, et al. Calcium Intake and Hip Fracture Risk in Men and Women: a Meta-analysis of Prospective Cohort Studies and Randomized Controlled Trials. Am J Clin Nutr. 2007;86(6):1780-90. PubMed PMID: 18065599.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Calcium intake and hip fracture risk in men and women: a meta-analysis of prospective cohort studies and randomized controlled trials. AU - Bischoff-Ferrari,Heike A, AU - Dawson-Hughes,Bess, AU - Baron,John A, AU - Burckhardt,Peter, AU - Li,Ruifeng, AU - Spiegelman,Donna, AU - Specker,Bonny, AU - Orav,John E, AU - Wong,John B, AU - Staehelin,Hannes B, AU - O'Reilly,Eilis, AU - Kiel,Douglas P, AU - Willett,Walter C, PY - 2007/12/11/pubmed PY - 2008/1/23/medline PY - 2007/12/11/entrez SP - 1780 EP - 90 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 86 IS - 6 N2 - BACKGROUND: The role of total calcium intake in the prevention of hip fracture risk has not been well established. OBJECTIVE: The objective of the study was to assess the relation of calcium intake to the risk of hip fracture on the basis of meta-analyses of cohort studies and clinical trials. RESULTS: In women (7 prospective cohort studies, 170,991 women, 2,954 hip fractures), there was no association between total calcium intake and hip fracture risk [pooled risk ratio (RR) per 300 mg total Ca/d = 1.01; 95% CI: 0.97, 1.05]. In men (5 prospective cohort studies, 68,606 men, 214 hip fractures), the pooled RR per 300 mg total Ca/d was 0.92 (95% CI: 0.82, 1.03). On the basis of 5 clinical trials (n = 5666 women, primarily postmenopausal, plus 1074 men) with 814 nonvertebral fractures, the pooled RR for nonvertebral fractures between calcium supplementation (800-1600 mg/d) and placebo was 0.92 (95% CI: 0.81, 1.05). On the basis of 4 clinical trials with separate results for hip fracture (6,504 subjects with 139 hip fractures), the pooled RR between calcium and placebo was 1.64 (95% CI:1.02, 2.64). Sensitivity analyses including 2 additional small trials with <100 participants or per-protocol results did not substantially alter results. CONCLUSIONS: Pooled results from prospective cohort studies suggest that calcium intake is not significantly associated with hip fracture risk in women or men. Pooled results from randomized controlled trials show no reduction in hip fracture risk with calcium supplementation, and an increased risk is possible. For any nonvertebral fractures, there was a neutral effect in the randomized trials. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/18065599/Calcium_intake_and_hip_fracture_risk_in_men_and_women:_a_meta_analysis_of_prospective_cohort_studies_and_randomized_controlled_trials_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/86.5.1780 DB - PRIME DP - Unbound Medicine ER -