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Participation of hippocampal ionotropic glutamate receptors in histamine H(1) antagonist-induced memory deficit in rats.
Psychopharmacology (Berl). 2008 Mar; 197(1):107-14.P

Abstract

RATIONALE

Pyrilamine, a selective histamine H(1) antagonist, impaired spatial memory, and decreased hippocampal theta activity during a radial maze task.

OBJECTIVE

We investigated the ameliorative effects of glutamatergic drugs on pyrilamine-induced spatial memory deficit and the decrease in hippocampal theta activity in rats.

MATERIALS AND METHODS

Drug effects were measured using an eight-arm radial maze with four arms baited. Hippocampal theta rhythm during the radial maze task was also recorded with a polygraph system using a telemetric technique.

RESULTS

Intraperitoneal injection of pyrilamine (35 mg/kg) resulted in impaired reference and working memory in the radial maze task and a decrease in the amplitude and power of hippocampal theta waves. The working memory deficit and the decrease in hippocampal theta power were antagonized by intrahippocampal injection of D: -cycloserine (1 microg/side), spermidine (10 microg/side), spermine (10 microg/side), aniracetam (1 microg/side), and 1-(1,3-benzodioxol-5-ylcarbonyl) piperidine (1-BCP) (1 microg/side), but not concanavalin A.

CONCLUSION

These results clearly indicate that H(1) antagonist-induced working memory deficit, and the decrease in hippocampal theta activity was closely associated with hippocampal glutamatergic neurotransmission mediated by N-methyl-D: -aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors.

Authors+Show Affiliations

Masuoka T
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8530, Japan.
Saito S
No affiliation info available
Kamei C
No affiliation info available

MeSH

AnimalsConcanavalin ACycloserineDioxolesDose-Response Relationship, DrugElectroencephalographyFourier AnalysisHippocampusHistamine H1 AntagonistsInjectionsMaleMaze LearningMental RecallOrientationPiperidinesPyrilaminePyrrolidinonesRatsRats, WistarReceptors, AMPAReceptors, Histamine H1Receptors, Kainic AcidReceptors, N-Methyl-D-AspartateSignal Processing, Computer-AssistedSpermidineSpermineTheta Rhythm

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18066536

Citation

Masuoka, Takayoshi, et al. "Participation of Hippocampal Ionotropic Glutamate Receptors in Histamine H(1) Antagonist-induced Memory Deficit in Rats." Psychopharmacology, vol. 197, no. 1, 2008, pp. 107-14.
Masuoka T, Saito S, Kamei C. Participation of hippocampal ionotropic glutamate receptors in histamine H(1) antagonist-induced memory deficit in rats. Psychopharmacology (Berl). 2008;197(1):107-14.
Masuoka, T., Saito, S., & Kamei, C. (2008). Participation of hippocampal ionotropic glutamate receptors in histamine H(1) antagonist-induced memory deficit in rats. Psychopharmacology, 197(1), 107-14.
Masuoka T, Saito S, Kamei C. Participation of Hippocampal Ionotropic Glutamate Receptors in Histamine H(1) Antagonist-induced Memory Deficit in Rats. Psychopharmacology (Berl). 2008;197(1):107-14. PubMed PMID: 18066536.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Participation of hippocampal ionotropic glutamate receptors in histamine H(1) antagonist-induced memory deficit in rats. AU - Masuoka,Takayoshi, AU - Saito,Shunsuke, AU - Kamei,Chiaki, Y1 - 2007/12/07/ PY - 2007/05/24/received PY - 2007/10/30/accepted PY - 2007/12/11/pubmed PY - 2008/8/30/medline PY - 2007/12/11/entrez SP - 107 EP - 14 JF - Psychopharmacology JO - Psychopharmacology (Berl) VL - 197 IS - 1 N2 - RATIONALE: Pyrilamine, a selective histamine H(1) antagonist, impaired spatial memory, and decreased hippocampal theta activity during a radial maze task. OBJECTIVE: We investigated the ameliorative effects of glutamatergic drugs on pyrilamine-induced spatial memory deficit and the decrease in hippocampal theta activity in rats. MATERIALS AND METHODS: Drug effects were measured using an eight-arm radial maze with four arms baited. Hippocampal theta rhythm during the radial maze task was also recorded with a polygraph system using a telemetric technique. RESULTS: Intraperitoneal injection of pyrilamine (35 mg/kg) resulted in impaired reference and working memory in the radial maze task and a decrease in the amplitude and power of hippocampal theta waves. The working memory deficit and the decrease in hippocampal theta power were antagonized by intrahippocampal injection of D: -cycloserine (1 microg/side), spermidine (10 microg/side), spermine (10 microg/side), aniracetam (1 microg/side), and 1-(1,3-benzodioxol-5-ylcarbonyl) piperidine (1-BCP) (1 microg/side), but not concanavalin A. CONCLUSION: These results clearly indicate that H(1) antagonist-induced working memory deficit, and the decrease in hippocampal theta activity was closely associated with hippocampal glutamatergic neurotransmission mediated by N-methyl-D: -aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. SN - 0033-3158 UR - https://www.unboundmedicine.com/medline/citation/18066536/Participation_of_hippocampal_ionotropic_glutamate_receptors_in_histamine_H_1__antagonist_induced_memory_deficit_in_rats_ DB - PRIME DP - Unbound Medicine ER -