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Combined effects of vitamin C, vitamin E, and sodium selenate supplementation on absolute ethanol-induced injury in various organs of rats.
Int J Toxicol. 2007 Nov-Dec; 26(6):513-23.IJ

Abstract

In this study, the effect of combination of vitamin C (ascorbic acid), vitamin E (alpha -tocopherol), and selenium (sodium selenate) on ethanol-induced liver and intestine injury in rats was investigated. The ethanol-induced injury was produced by the administration of 1 ml of absolute ethanol to each rats. Animals received vitamin C (250 mg/kg), vitamin E (250 mg/kg), and sodium selenate (Se) (0.5 mg/kg) for 3 days; 1 h after the final antioxidant administration, they were sacrificed. Lipid peroxidation and glutathione levels, catalase (CAT), lactate dehydrogenase (LDH), superoxide dismutase (SOD), and glutathione peroxidase (GP(x)) activities were determined in liver and intestine tissues. Myeloperoxidase (MPO), aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT) were determined in liver tissue. Also, CAT activity, urea, creatinine, uric acid, and total lipid levels were determined in serum samples. In the ethanol group, serum urea, creatinine, uric acid, and total lipid levels; liver and intestine LDH; liver MPO, AST, ALP, ALT, and GGT activities; and liver and intestine LPO levels increased, whereas serum CAT activity, liver and intestine GSH levels, and CAT, SOD, and GP(x) activities decreased. On the other hand, treatment with vitamin C, vitamin E, and Se reversed these effects. As a result of these findings, we can say that the combination of vitamin C, vitamin E, and selenium has a protective effect on ethanol-induced changes in lipid peroxidation, glutathione levels, and antioxidant enzyme activities in liver and intestine tissues, and in some serum parameters of rats.

Authors+Show Affiliations

Department of Chemistry, Faculty of Engineering, Istanbul University, Istanbul, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18066967

Citation

Yanardag, Refiye, et al. "Combined Effects of Vitamin C, Vitamin E, and Sodium Selenate Supplementation On Absolute Ethanol-induced Injury in Various Organs of Rats." International Journal of Toxicology, vol. 26, no. 6, 2007, pp. 513-23.
Yanardag R, Ozsoy-Sacan O, Ozdil S, et al. Combined effects of vitamin C, vitamin E, and sodium selenate supplementation on absolute ethanol-induced injury in various organs of rats. Int J Toxicol. 2007;26(6):513-23.
Yanardag, R., Ozsoy-Sacan, O., Ozdil, S., & Bolkent, S. (2007). Combined effects of vitamin C, vitamin E, and sodium selenate supplementation on absolute ethanol-induced injury in various organs of rats. International Journal of Toxicology, 26(6), 513-23.
Yanardag R, et al. Combined Effects of Vitamin C, Vitamin E, and Sodium Selenate Supplementation On Absolute Ethanol-induced Injury in Various Organs of Rats. Int J Toxicol. 2007 Nov-Dec;26(6):513-23. PubMed PMID: 18066967.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined effects of vitamin C, vitamin E, and sodium selenate supplementation on absolute ethanol-induced injury in various organs of rats. AU - Yanardag,Refiye, AU - Ozsoy-Sacan,Ozlem, AU - Ozdil,Sadakat, AU - Bolkent,Sehnaz, PY - 2007/12/11/pubmed PY - 2008/3/18/medline PY - 2007/12/11/entrez SP - 513 EP - 23 JF - International journal of toxicology JO - Int J Toxicol VL - 26 IS - 6 N2 - In this study, the effect of combination of vitamin C (ascorbic acid), vitamin E (alpha -tocopherol), and selenium (sodium selenate) on ethanol-induced liver and intestine injury in rats was investigated. The ethanol-induced injury was produced by the administration of 1 ml of absolute ethanol to each rats. Animals received vitamin C (250 mg/kg), vitamin E (250 mg/kg), and sodium selenate (Se) (0.5 mg/kg) for 3 days; 1 h after the final antioxidant administration, they were sacrificed. Lipid peroxidation and glutathione levels, catalase (CAT), lactate dehydrogenase (LDH), superoxide dismutase (SOD), and glutathione peroxidase (GP(x)) activities were determined in liver and intestine tissues. Myeloperoxidase (MPO), aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT) were determined in liver tissue. Also, CAT activity, urea, creatinine, uric acid, and total lipid levels were determined in serum samples. In the ethanol group, serum urea, creatinine, uric acid, and total lipid levels; liver and intestine LDH; liver MPO, AST, ALP, ALT, and GGT activities; and liver and intestine LPO levels increased, whereas serum CAT activity, liver and intestine GSH levels, and CAT, SOD, and GP(x) activities decreased. On the other hand, treatment with vitamin C, vitamin E, and Se reversed these effects. As a result of these findings, we can say that the combination of vitamin C, vitamin E, and selenium has a protective effect on ethanol-induced changes in lipid peroxidation, glutathione levels, and antioxidant enzyme activities in liver and intestine tissues, and in some serum parameters of rats. SN - 1091-5818 UR - https://www.unboundmedicine.com/medline/citation/18066967/Combined_effects_of_vitamin_C_vitamin_E_and_sodium_selenate_supplementation_on_absolute_ethanol_induced_injury_in_various_organs_of_rats_ L2 - https://journals.sagepub.com/doi/10.1080/10915810701707296?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -