Tags

Type your tag names separated by a space and hit enter

Association of olfactory dysfunction with risk for future Parkinson's disease.
Ann Neurol. 2008 Feb; 63(2):167-73.AN

Abstract

OBJECTIVE

Although olfactory dysfunction is commonly associated with Parkinson's disease (PD), it is not known whether such dysfunction can predate the onset of clinical PD in a community-based population. This study examines the association of olfactory dysfunction with future development of PD in Honolulu-Asia Aging Study cohort members

METHODS

Olfaction was assessed from 1991 to 1996 in 2,267 men in the Honolulu-Asia Aging Study aged 71 to 95 years who were free of clinical PD and dementia at the time of olfaction testing. Participants were followed for up to 8 years for incident PD RESULTS: In the course of follow-up, 35 men were diagnosed with PD (24.6/10,000 person-years). The average age at the time of diagnosis was 82.9 +/- 3.8 (range, 76-93) years, and the average time to a diagnosis was 4.0 +/- 1.9 (range, 1-8) years. During the first 4 years of follow-up, age-adjusted incidence of PD declined from 54.5/10,000 person-years in the lowest quartile of odor identification to 26.6, 8.2, and 8.4/10,000 person-years in the second, third, and fourth quartiles, respectively (p < 0.001 for trend). After adjustment for age and other potential confounders, the odds ratios for PD in the lowest quartile was 5.2 (95% confidence interval, 1.5-25.6) compared with the top two quartiles. This relation was not evident beyond 4 years of follow-up.

INTERPRETATION

Impaired olfaction can predate clinical PD in men by at least 4 years and may be a useful screening tool to detect those at high risk for development of PD in later life.

Authors+Show Affiliations

Veterans Affairs Pacific Islands Health Care System, University of Hawaii John A. Burns School of Medicine, Honolulu, HI 96819, USA. wross@phrihawaii.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

18067173

Citation

Ross, G Webster, et al. "Association of Olfactory Dysfunction With Risk for Future Parkinson's Disease." Annals of Neurology, vol. 63, no. 2, 2008, pp. 167-73.
Ross GW, Petrovitch H, Abbott RD, et al. Association of olfactory dysfunction with risk for future Parkinson's disease. Ann Neurol. 2008;63(2):167-73.
Ross, G. W., Petrovitch, H., Abbott, R. D., Tanner, C. M., Popper, J., Masaki, K., Launer, L., & White, L. R. (2008). Association of olfactory dysfunction with risk for future Parkinson's disease. Annals of Neurology, 63(2), 167-73.
Ross GW, et al. Association of Olfactory Dysfunction With Risk for Future Parkinson's Disease. Ann Neurol. 2008;63(2):167-73. PubMed PMID: 18067173.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of olfactory dysfunction with risk for future Parkinson's disease. AU - Ross,G Webster, AU - Petrovitch,Helen, AU - Abbott,Robert D, AU - Tanner,Caroline M, AU - Popper,Jordan, AU - Masaki,Kamal, AU - Launer,Lenore, AU - White,Lon R, PY - 2007/12/11/pubmed PY - 2008/4/4/medline PY - 2007/12/11/entrez SP - 167 EP - 73 JF - Annals of neurology JO - Ann Neurol VL - 63 IS - 2 N2 - OBJECTIVE: Although olfactory dysfunction is commonly associated with Parkinson's disease (PD), it is not known whether such dysfunction can predate the onset of clinical PD in a community-based population. This study examines the association of olfactory dysfunction with future development of PD in Honolulu-Asia Aging Study cohort members METHODS: Olfaction was assessed from 1991 to 1996 in 2,267 men in the Honolulu-Asia Aging Study aged 71 to 95 years who were free of clinical PD and dementia at the time of olfaction testing. Participants were followed for up to 8 years for incident PD RESULTS: In the course of follow-up, 35 men were diagnosed with PD (24.6/10,000 person-years). The average age at the time of diagnosis was 82.9 +/- 3.8 (range, 76-93) years, and the average time to a diagnosis was 4.0 +/- 1.9 (range, 1-8) years. During the first 4 years of follow-up, age-adjusted incidence of PD declined from 54.5/10,000 person-years in the lowest quartile of odor identification to 26.6, 8.2, and 8.4/10,000 person-years in the second, third, and fourth quartiles, respectively (p < 0.001 for trend). After adjustment for age and other potential confounders, the odds ratios for PD in the lowest quartile was 5.2 (95% confidence interval, 1.5-25.6) compared with the top two quartiles. This relation was not evident beyond 4 years of follow-up. INTERPRETATION: Impaired olfaction can predate clinical PD in men by at least 4 years and may be a useful screening tool to detect those at high risk for development of PD in later life. SN - 1531-8249 UR - https://www.unboundmedicine.com/medline/citation/18067173/Association_of_olfactory_dysfunction_with_risk_for_future_Parkinson's_disease_ L2 - https://doi.org/10.1002/ana.21291 DB - PRIME DP - Unbound Medicine ER -