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[Study on the status of human rhinovirus infections in infants and young children with acute respiratory infections in Beijing, from 2002 to 2006].
Zhonghua Liu Xing Bing Xue Za Zhi. 2007 Jul; 28(7):683-5.ZL

Abstract

OBJECTIVE

To understand the relationship between human rhinovirus (HRV) and acute respiratory infections in infants and young children in Beijing.

METHODS

Throat swab/nasopharyngeal aspirates were collected from 3292 infants and young children with acute respiratory tract infections in Beijing from November 2002 to November 2006. Primers derived from the highly conserved 5'-noncoding region of human rhinovirus were used to detect HRV from clinical specimens by nested RT-PCR for which the sensitivity and specificity had been determined previously.

RESULTS

Out of these 3292 specimens, 507 were (15.4%, 507/3292) HRV positive with RT-PCR method. HRV were detected from 220 out of 1315 outpatients and 287 out of 1977 inpatients with positive rates as 16.7% and 14.5% respectively. HRV was detected from 50.0% (8/16) of the patients with pharyngitis. Among 280 specimens collected from patients with acute bronchitis, 43 (15.4%) were HRV positive, including 14 from 80 patients with wheezy bronchitis (17.5%). High positive rates were also found in specimens from patients with pneumonia (12.6%, 150/1189), bronchiolitis (16.0%, 42/262) and asthma (12.8%, 10/78). In 53 patients with initial diagnosis as hematic disease or other complicate respiratory infections, 14 were HRV (26.4%, 14/53) positive. As for the seasonal distribution, HRV were detected in most of the months during thie period of research. The highest positive rate of HRV in each year fell in September (32.6%), February (24.2%) of 2004, February of 2005 (35.3%) and March (31.3%) from 2003 to 2006, respectively. Among these HRV positive patients, 44.8% were under 1 year of age (227/507), 15.4% (78/507) were 1 to 2 years old and 12.4% (63/507) were 2 to 3 years old.

CONCLUSION

HRV was associated with acute upper respiratory infections and lower respiratory infections including bronchitis, pneumonia and bronchiolitis in pediatric patients. Patients with lower immunity such as those with hematic diseases, were more susceptible to be infected by HRV. HRV could be detected in all age groups in this study, but the positive rates were decreasing with the increase of patients' age. Infants under 1 year of age seemed to be more likely to get HRV infection.

Authors+Show Affiliations

Laboratory of Virology, Beijing Municipal Laboratory of Infection and Immunity, Capital Institute of Pediatrics, Beijing 100020, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

18069559

Citation

Zhao, Lin-Qing, et al. "[Study On the Status of Human Rhinovirus Infections in Infants and Young Children With Acute Respiratory Infections in Beijing, From 2002 to 2006]." Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi, vol. 28, no. 7, 2007, pp. 683-5.
Zhao LQ, Qian Y, Zhu RN, et al. [Study on the status of human rhinovirus infections in infants and young children with acute respiratory infections in Beijing, from 2002 to 2006]. Zhonghua Liu Xing Bing Xue Za Zhi. 2007;28(7):683-5.
Zhao, L. Q., Qian, Y., Zhu, R. N., Deng, J., & Wang, F. (2007). [Study on the status of human rhinovirus infections in infants and young children with acute respiratory infections in Beijing, from 2002 to 2006]. Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi, 28(7), 683-5.
Zhao LQ, et al. [Study On the Status of Human Rhinovirus Infections in Infants and Young Children With Acute Respiratory Infections in Beijing, From 2002 to 2006]. Zhonghua Liu Xing Bing Xue Za Zhi. 2007;28(7):683-5. PubMed PMID: 18069559.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study on the status of human rhinovirus infections in infants and young children with acute respiratory infections in Beijing, from 2002 to 2006]. AU - Zhao,Lin-Qing, AU - Qian,Yuan, AU - Zhu,Ru-Nan, AU - Deng,Jie, AU - Wang,Fang, PY - 2007/12/12/pubmed PY - 2010/5/29/medline PY - 2007/12/12/entrez SP - 683 EP - 5 JF - Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi JO - Zhonghua Liu Xing Bing Xue Za Zhi VL - 28 IS - 7 N2 - OBJECTIVE: To understand the relationship between human rhinovirus (HRV) and acute respiratory infections in infants and young children in Beijing. METHODS: Throat swab/nasopharyngeal aspirates were collected from 3292 infants and young children with acute respiratory tract infections in Beijing from November 2002 to November 2006. Primers derived from the highly conserved 5'-noncoding region of human rhinovirus were used to detect HRV from clinical specimens by nested RT-PCR for which the sensitivity and specificity had been determined previously. RESULTS: Out of these 3292 specimens, 507 were (15.4%, 507/3292) HRV positive with RT-PCR method. HRV were detected from 220 out of 1315 outpatients and 287 out of 1977 inpatients with positive rates as 16.7% and 14.5% respectively. HRV was detected from 50.0% (8/16) of the patients with pharyngitis. Among 280 specimens collected from patients with acute bronchitis, 43 (15.4%) were HRV positive, including 14 from 80 patients with wheezy bronchitis (17.5%). High positive rates were also found in specimens from patients with pneumonia (12.6%, 150/1189), bronchiolitis (16.0%, 42/262) and asthma (12.8%, 10/78). In 53 patients with initial diagnosis as hematic disease or other complicate respiratory infections, 14 were HRV (26.4%, 14/53) positive. As for the seasonal distribution, HRV were detected in most of the months during thie period of research. The highest positive rate of HRV in each year fell in September (32.6%), February (24.2%) of 2004, February of 2005 (35.3%) and March (31.3%) from 2003 to 2006, respectively. Among these HRV positive patients, 44.8% were under 1 year of age (227/507), 15.4% (78/507) were 1 to 2 years old and 12.4% (63/507) were 2 to 3 years old. CONCLUSION: HRV was associated with acute upper respiratory infections and lower respiratory infections including bronchitis, pneumonia and bronchiolitis in pediatric patients. Patients with lower immunity such as those with hematic diseases, were more susceptible to be infected by HRV. HRV could be detected in all age groups in this study, but the positive rates were decreasing with the increase of patients' age. Infants under 1 year of age seemed to be more likely to get HRV infection. SN - 0254-6450 UR - https://www.unboundmedicine.com/medline/citation/18069559/[Study_on_the_status_of_human_rhinovirus_infections_in_infants_and_young_children_with_acute_respiratory_infections_in_Beijing_from_2002_to_2006]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0254-6450&year=2007&vol=28&issue=7&fpage=683 DB - PRIME DP - Unbound Medicine ER -