Tags

Type your tag names separated by a space and hit enter

Reduced positive affect (anhedonia) predicts major clinical events following implantation of coronary-artery stents.
J Intern Med. 2008 Feb; 263(2):203-11.JI

Abstract

OBJECTIVE

Emotional distress has been related to clinical events in patients with coronary artery disease, but the influence of positive affect (i.e. mood states such as activity, joy and cheerfulness) has received little attention. Therefore, we wanted to investigate the role of positive affect on clinical outcome after percutaneous coronary intervention (PCI) with stent implantation in these patients.

DESIGN

Prospective follow-up study. At baseline, patients from the Rapamycin-Eluting Stent Evaluated At Rotterdam Cardiology Hospital (RESEARCH) registry completed measures of positive affect, depression and anxiety post-PCI. Patients with reduced positive affect scored 1 SD below the mean score.

SETTING

University Hospital; Thoraxcenter of the Department of Cardiology.

SUBJECTS

874 patients (72% men; 62.2 +/- 10.9 years) from the RESEARCH registry. Main outcome measure. Death or myocardial infarction (MI) 2 years post-PCI.

RESULTS

At follow-up, there were 52 clinical events (deaths n = 27, MIs n = 25). Reduced positive affect and depression/anxiety were associated with poor prognosis, but reduced positive affect was the only independent predictor of events. The incidence of death/MI in adequate versus reduced positive affect patients was 4% (29/663) vs. 11% (23/211); HR = 2.55 (95% CI 1.46-4.34, P = 0.001), adjusting for clinical variables. Reduced positive affect and diabetes were independent prognostic factors, and patients with one (HR = 2.84, 95% CI 1.58-5.10) or both (HR = 5.61, 95% CI 2.25-13.99) of these factors had a higher risk when compared with nondiabetic patients with adequate positive affect, P < or = 0.003.

CONCLUSIONS

Reduced positive affect independently predicted death/MI following stent implantation, and improved risk stratification above and beyond diabetes.

Authors+Show Affiliations

CoRPS-Center of Research on Psychology in Somatic Diseases, Tilburg University, Tilburg, The Netherlands. denollet@uvt.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18069998

Citation

Denollet, J, et al. "Reduced Positive Affect (anhedonia) Predicts Major Clinical Events Following Implantation of Coronary-artery Stents." Journal of Internal Medicine, vol. 263, no. 2, 2008, pp. 203-11.
Denollet J, Pedersen SS, Daemen J, et al. Reduced positive affect (anhedonia) predicts major clinical events following implantation of coronary-artery stents. J Intern Med. 2008;263(2):203-11.
Denollet, J., Pedersen, S. S., Daemen, J., de Jaegere, P., Serruys, P. W., & van Domburg, R. T. (2008). Reduced positive affect (anhedonia) predicts major clinical events following implantation of coronary-artery stents. Journal of Internal Medicine, 263(2), 203-11.
Denollet J, et al. Reduced Positive Affect (anhedonia) Predicts Major Clinical Events Following Implantation of Coronary-artery Stents. J Intern Med. 2008;263(2):203-11. PubMed PMID: 18069998.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduced positive affect (anhedonia) predicts major clinical events following implantation of coronary-artery stents. AU - Denollet,J, AU - Pedersen,S S, AU - Daemen,J, AU - de Jaegere,P, AU - Serruys,P W, AU - van Domburg,R T, Y1 - 2007/12/05/ PY - 2007/12/12/pubmed PY - 2008/3/4/medline PY - 2007/12/12/entrez SP - 203 EP - 11 JF - Journal of internal medicine JO - J. Intern. Med. VL - 263 IS - 2 N2 - OBJECTIVE: Emotional distress has been related to clinical events in patients with coronary artery disease, but the influence of positive affect (i.e. mood states such as activity, joy and cheerfulness) has received little attention. Therefore, we wanted to investigate the role of positive affect on clinical outcome after percutaneous coronary intervention (PCI) with stent implantation in these patients. DESIGN: Prospective follow-up study. At baseline, patients from the Rapamycin-Eluting Stent Evaluated At Rotterdam Cardiology Hospital (RESEARCH) registry completed measures of positive affect, depression and anxiety post-PCI. Patients with reduced positive affect scored 1 SD below the mean score. SETTING: University Hospital; Thoraxcenter of the Department of Cardiology. SUBJECTS: 874 patients (72% men; 62.2 +/- 10.9 years) from the RESEARCH registry. Main outcome measure. Death or myocardial infarction (MI) 2 years post-PCI. RESULTS: At follow-up, there were 52 clinical events (deaths n = 27, MIs n = 25). Reduced positive affect and depression/anxiety were associated with poor prognosis, but reduced positive affect was the only independent predictor of events. The incidence of death/MI in adequate versus reduced positive affect patients was 4% (29/663) vs. 11% (23/211); HR = 2.55 (95% CI 1.46-4.34, P = 0.001), adjusting for clinical variables. Reduced positive affect and diabetes were independent prognostic factors, and patients with one (HR = 2.84, 95% CI 1.58-5.10) or both (HR = 5.61, 95% CI 2.25-13.99) of these factors had a higher risk when compared with nondiabetic patients with adequate positive affect, P < or = 0.003. CONCLUSIONS: Reduced positive affect independently predicted death/MI following stent implantation, and improved risk stratification above and beyond diabetes. SN - 1365-2796 UR - https://www.unboundmedicine.com/medline/citation/18069998/Reduced_positive_affect__anhedonia__predicts_major_clinical_events_following_implantation_of_coronary_artery_stents_ L2 - https://doi.org/10.1111/j.1365-2796.2007.01870.x DB - PRIME DP - Unbound Medicine ER -