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Supported liquid-liquid extraction of the active ingredient (3,4-methylenedioxymethylamphetamine) from ecstasy tablets for isotopic analysis.
J Chromatogr A. 2008 Jan 18; 1178(1-2):1-8.JC

Abstract

A method was developed for the isolation of 3,4-methylenedioxymethylamphetamine (MDMA) and other active ingredients from illicit ecstasy tablets. The method employed supported liquid extraction (SLE) with cartridges containing a modified form of diatomaceous earth. The method developed was simple and robust and the extract could be analysed directly, by GC-MS, to identify ingredients and reduced in volume for isotope ratio MS analysis of both delta(13)C and delta(15)N. The technique was shown to be highly reproducible, independent of the tablet matrix and considerably faster than existing liquid-liquid extraction methods. Crucially, no significant isotopic fractionation was observed as a result of the extraction process.

Authors+Show Affiliations

Centre for Forensic Science, Department of Pure and Applied Chemistry, University of Strathclyde, Royal College, 204 George Street, Glasgow G1 1XW, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18070626

Citation

de Korompay, Alanna, et al. "Supported Liquid-liquid Extraction of the Active Ingredient (3,4-methylenedioxymethylamphetamine) From Ecstasy Tablets for Isotopic Analysis." Journal of Chromatography. A, vol. 1178, no. 1-2, 2008, pp. 1-8.
de Korompay A, Hill JC, Carter JF, et al. Supported liquid-liquid extraction of the active ingredient (3,4-methylenedioxymethylamphetamine) from ecstasy tablets for isotopic analysis. J Chromatogr A. 2008;1178(1-2):1-8.
de Korompay, A., Hill, J. C., Carter, J. F., NicDaeid, N., & Sleeman, R. (2008). Supported liquid-liquid extraction of the active ingredient (3,4-methylenedioxymethylamphetamine) from ecstasy tablets for isotopic analysis. Journal of Chromatography. A, 1178(1-2), 1-8.
de Korompay A, et al. Supported Liquid-liquid Extraction of the Active Ingredient (3,4-methylenedioxymethylamphetamine) From Ecstasy Tablets for Isotopic Analysis. J Chromatogr A. 2008 Jan 18;1178(1-2):1-8. PubMed PMID: 18070626.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Supported liquid-liquid extraction of the active ingredient (3,4-methylenedioxymethylamphetamine) from ecstasy tablets for isotopic analysis. AU - de Korompay,Alanna, AU - Hill,Jenny C, AU - Carter,James F, AU - NicDaeid,Niamh, AU - Sleeman,Richard, Y1 - 2007/11/22/ PY - 2007/10/04/received PY - 2007/11/06/revised PY - 2007/11/09/accepted PY - 2007/12/12/pubmed PY - 2008/4/23/medline PY - 2007/12/12/entrez SP - 1 EP - 8 JF - Journal of chromatography. A JO - J Chromatogr A VL - 1178 IS - 1-2 N2 - A method was developed for the isolation of 3,4-methylenedioxymethylamphetamine (MDMA) and other active ingredients from illicit ecstasy tablets. The method employed supported liquid extraction (SLE) with cartridges containing a modified form of diatomaceous earth. The method developed was simple and robust and the extract could be analysed directly, by GC-MS, to identify ingredients and reduced in volume for isotope ratio MS analysis of both delta(13)C and delta(15)N. The technique was shown to be highly reproducible, independent of the tablet matrix and considerably faster than existing liquid-liquid extraction methods. Crucially, no significant isotopic fractionation was observed as a result of the extraction process. SN - 0021-9673 UR - https://www.unboundmedicine.com/medline/citation/18070626/Supported_liquid_liquid_extraction_of_the_active_ingredient__34_methylenedioxymethylamphetamine__from_ecstasy_tablets_for_isotopic_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9673(07)01958-9 DB - PRIME DP - Unbound Medicine ER -