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Diabetes and endometrial cancer: an evaluation of the modifying effects of other known risk factors.
Am J Epidemiol. 2008 Mar 01; 167(5):607-14.AJ

Abstract

To determine whether risk of endometrial cancer among women with type 2 diabetes differs with respect to other endometrial cancer risk factors, the authors used data from a population-based case-control study (1,303 cases and 1,779 controls) conducted in western Washington State during 1985-1999. History of type 2 diabetes was associated with endometrial cancer (odds ratio (OR) = 1.7, 95% confidence interval (CI): 1.2, 2.3), more strongly among women with a recent diabetes diagnosis (<5 years) (OR = 2.6, CI: 1.5, 4.7) than among those with a more distant diagnosis (> or =5 years) (OR = 1.3, CI: 0.8, 1.9). Type 2 diabetes was associated with endometrial cancer among women with a body mass index (BMI) (weight (kg)/height (m)(2)) less than 35 but not among women with a BMI of 35 or more. The observed associations persisted after finer adjustment for BMI to control for residual confounding. History of diabetes was associated with a twofold increased risk of endometrial cancer among hypertensive women, but no association was observed among nonhypertensive women. The risk associated with type 2 diabetes appeared not to vary greatly with respect to other endometrial cancer risk factors. These results support the hypothesis that type 2 diabetes is associated with endometrial cancer irrespective of the presence of other risk factors for this disease, except possibly hypertension and extreme obesity.

Authors+Show Affiliations

Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18071194

Citation

Saltzman, Babette S., et al. "Diabetes and Endometrial Cancer: an Evaluation of the Modifying Effects of Other Known Risk Factors." American Journal of Epidemiology, vol. 167, no. 5, 2008, pp. 607-14.
Saltzman BS, Doherty JA, Hill DA, et al. Diabetes and endometrial cancer: an evaluation of the modifying effects of other known risk factors. Am J Epidemiol. 2008;167(5):607-14.
Saltzman, B. S., Doherty, J. A., Hill, D. A., Beresford, S. A., Voigt, L. F., Chen, C., & Weiss, N. S. (2008). Diabetes and endometrial cancer: an evaluation of the modifying effects of other known risk factors. American Journal of Epidemiology, 167(5), 607-14.
Saltzman BS, et al. Diabetes and Endometrial Cancer: an Evaluation of the Modifying Effects of Other Known Risk Factors. Am J Epidemiol. 2008 Mar 1;167(5):607-14. PubMed PMID: 18071194.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diabetes and endometrial cancer: an evaluation of the modifying effects of other known risk factors. AU - Saltzman,Babette S, AU - Doherty,Jennifer A, AU - Hill,Deirdre A, AU - Beresford,Shirley A, AU - Voigt,Lynda F, AU - Chen,Chu, AU - Weiss,Noel S, Y1 - 2007/12/10/ PY - 2007/12/12/pubmed PY - 2008/3/26/medline PY - 2007/12/12/entrez SP - 607 EP - 14 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 167 IS - 5 N2 - To determine whether risk of endometrial cancer among women with type 2 diabetes differs with respect to other endometrial cancer risk factors, the authors used data from a population-based case-control study (1,303 cases and 1,779 controls) conducted in western Washington State during 1985-1999. History of type 2 diabetes was associated with endometrial cancer (odds ratio (OR) = 1.7, 95% confidence interval (CI): 1.2, 2.3), more strongly among women with a recent diabetes diagnosis (<5 years) (OR = 2.6, CI: 1.5, 4.7) than among those with a more distant diagnosis (> or =5 years) (OR = 1.3, CI: 0.8, 1.9). Type 2 diabetes was associated with endometrial cancer among women with a body mass index (BMI) (weight (kg)/height (m)(2)) less than 35 but not among women with a BMI of 35 or more. The observed associations persisted after finer adjustment for BMI to control for residual confounding. History of diabetes was associated with a twofold increased risk of endometrial cancer among hypertensive women, but no association was observed among nonhypertensive women. The risk associated with type 2 diabetes appeared not to vary greatly with respect to other endometrial cancer risk factors. These results support the hypothesis that type 2 diabetes is associated with endometrial cancer irrespective of the presence of other risk factors for this disease, except possibly hypertension and extreme obesity. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/18071194/Diabetes_and_endometrial_cancer:_an_evaluation_of_the_modifying_effects_of_other_known_risk_factors_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwm333 DB - PRIME DP - Unbound Medicine ER -