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A high glycemic meal suppresses the postprandial leptin response in normal healthy adults.

Abstract

BACKGROUND/AIMS

To evaluate the metabolic effects of meals with varying glycemic index (GI).

METHODS

We measured the glucose, insulin and leptin responses to two contrasting breakfast cereals in a group of 10 young healthy volunteers. Meals were provided on two separate occasions in random order after a 12-hour overnight fast, and consisted of 50 g of available carbohydrate from either Corn Flakes (Kellogg's), or Fiber One (General Mills). Blood samples were obtained at rest, and 30, 60, 90 and 120 min after eating. The GI was calculated from the glucose response to the test meal normalized against a 50 g oral glucose load.

RESULTS

The GI for Corn Flakes was 125 +/- 17 units and 49 +/- 8 units for Fiber One(R). These meals were classified as high GI and low GI, respectively, and were significantly different from each other (p < 0.0003). The area under the insulin response curve (AUC) following the low glycemic meal was significantly attenuated compared to the high glycemic meal (14,064 +/- 2,694 vs. 6,828 +/- 1,182 pmol/l.min, p < 0.02). The leptin AUC revealed that circulating leptin was suppressed by the high glycemic meal compared to the low (3.1 +/- 1.5 vs. 9.6 +/- 3.6 ng/ml.min, p < 0.04).

CONCLUSIONS

Lower insulin and higher leptin suggests that low glycemic meals promote a postprandial metabolic milieu that is favorable for reduced food consumption; this may be advantageous in the control of obesity and related disorders including insulin resistance and type 2 diabetes.

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  • Authors+Show Affiliations

    ,

    Schwartz Center for Metabolism and Nutrition, Case Western Reserve University School of Medicine and MetroHealth Medical Center, Cleveland, Ohio, USA.

    , , , ,

    Source

    MeSH

    Adolescent
    Adult
    Area Under Curve
    Blood Glucose
    Dietary Carbohydrates
    Female
    Glucose Tolerance Test
    Humans
    Leptin
    Male
    Postprandial Period
    Reference Values

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    18073462

    Citation

    Barkoukis, Hope, et al. "A High Glycemic Meal Suppresses the Postprandial Leptin Response in Normal Healthy Adults." Annals of Nutrition & Metabolism, vol. 51, no. 6, 2007, pp. 512-8.
    Barkoukis H, Marchetti CM, Nolan B, et al. A high glycemic meal suppresses the postprandial leptin response in normal healthy adults. Ann Nutr Metab. 2007;51(6):512-8.
    Barkoukis, H., Marchetti, C. M., Nolan, B., Sistrun, S. N., Krishnan, R. K., & Kirwan, J. P. (2007). A high glycemic meal suppresses the postprandial leptin response in normal healthy adults. Annals of Nutrition & Metabolism, 51(6), pp. 512-8.
    Barkoukis H, et al. A High Glycemic Meal Suppresses the Postprandial Leptin Response in Normal Healthy Adults. Ann Nutr Metab. 2007;51(6):512-8. PubMed PMID: 18073462.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A high glycemic meal suppresses the postprandial leptin response in normal healthy adults. AU - Barkoukis,Hope, AU - Marchetti,Christine M, AU - Nolan,Brian, AU - Sistrun,Sakita N, AU - Krishnan,Raj K, AU - Kirwan,John P, Y1 - 2007/12/10/ PY - 2007/04/30/received PY - 2007/10/03/accepted PY - 2007/12/13/pubmed PY - 2008/8/9/medline PY - 2007/12/13/entrez SP - 512 EP - 8 JF - Annals of nutrition & metabolism JO - Ann. Nutr. Metab. VL - 51 IS - 6 N2 - BACKGROUND/AIMS: To evaluate the metabolic effects of meals with varying glycemic index (GI). METHODS: We measured the glucose, insulin and leptin responses to two contrasting breakfast cereals in a group of 10 young healthy volunteers. Meals were provided on two separate occasions in random order after a 12-hour overnight fast, and consisted of 50 g of available carbohydrate from either Corn Flakes (Kellogg's), or Fiber One (General Mills). Blood samples were obtained at rest, and 30, 60, 90 and 120 min after eating. The GI was calculated from the glucose response to the test meal normalized against a 50 g oral glucose load. RESULTS: The GI for Corn Flakes was 125 +/- 17 units and 49 +/- 8 units for Fiber One(R). These meals were classified as high GI and low GI, respectively, and were significantly different from each other (p < 0.0003). The area under the insulin response curve (AUC) following the low glycemic meal was significantly attenuated compared to the high glycemic meal (14,064 +/- 2,694 vs. 6,828 +/- 1,182 pmol/l.min, p < 0.02). The leptin AUC revealed that circulating leptin was suppressed by the high glycemic meal compared to the low (3.1 +/- 1.5 vs. 9.6 +/- 3.6 ng/ml.min, p < 0.04). CONCLUSIONS: Lower insulin and higher leptin suggests that low glycemic meals promote a postprandial metabolic milieu that is favorable for reduced food consumption; this may be advantageous in the control of obesity and related disorders including insulin resistance and type 2 diabetes. SN - 1421-9697 UR - https://www.unboundmedicine.com/medline/citation/18073462/A_high_glycemic_meal_suppresses_the_postprandial_leptin_response_in_normal_healthy_adults_ L2 - https://www.karger.com?DOI=10.1159/000112309 DB - PRIME DP - Unbound Medicine ER -