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Clinical characteristics of restless legs syndrome in end-stage renal failure and idiopathic RLS patients.
Mov Disord 2008; 23(6):811-6; quiz 926MD

Abstract

This study was done to identify the clinical characteristics of uremic restless legs syndrome (RLS). Consecutive uremic RLS patients (n = 15) and idiopathic RLS patients (iRLS; n = 20) were evaluated. The groups were compared with respect to their clinical course, subjective symptoms [using the Pittsburgh Sleep Quality Index (PSQI) and the International Restless Legs Syndrome Severity Scale (IRLS)], polysomnographic (PSG) variables, the results of the suggested immobilization test (SIT), and the drug doses used to treat RLS. The duration of the disorder was significantly shorter in the uremic RLS group than in the iRLS group. The PSQI and IRLS scores before treatment were higher in the uremic RLS group than in the iRLS group. The periodic leg movement index (PLM index) on PSG and the SIT index were also higher in the uremic RLS group (P < 0.001, respectively). The bromocriptine equivalent dose of dopaminergic agonists used to treat RLS was significantly higher in the uremic RLS group (P < 0.001). Uremic RLS appears to deteriorate faster and to become more severe than iRLS. Moreover, uremic RLS patients appear to have a decreased response to dopaminergic agonists.

Authors+Show Affiliations

Japan Somnology center, Neuropsychiatric Research Institute, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18074382

Citation

Enomoto, Minori, et al. "Clinical Characteristics of Restless Legs Syndrome in End-stage Renal Failure and Idiopathic RLS Patients." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 23, no. 6, 2008, pp. 811-6; quiz 926.
Enomoto M, Inoue Y, Namba K, et al. Clinical characteristics of restless legs syndrome in end-stage renal failure and idiopathic RLS patients. Mov Disord. 2008;23(6):811-6; quiz 926.
Enomoto, M., Inoue, Y., Namba, K., Munezawa, T., & Matsuura, M. (2008). Clinical characteristics of restless legs syndrome in end-stage renal failure and idiopathic RLS patients. Movement Disorders : Official Journal of the Movement Disorder Society, 23(6), pp. 811-6; quiz 926.
Enomoto M, et al. Clinical Characteristics of Restless Legs Syndrome in End-stage Renal Failure and Idiopathic RLS Patients. Mov Disord. 2008 Apr 30;23(6):811-6; quiz 926. PubMed PMID: 18074382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical characteristics of restless legs syndrome in end-stage renal failure and idiopathic RLS patients. AU - Enomoto,Minori, AU - Inoue,Yuichi, AU - Namba,Kazuyoshi, AU - Munezawa,Takashi, AU - Matsuura,Masato, PY - 2007/12/13/pubmed PY - 2008/8/7/medline PY - 2007/12/13/entrez SP - 811-6; quiz 926 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov. Disord. VL - 23 IS - 6 N2 - This study was done to identify the clinical characteristics of uremic restless legs syndrome (RLS). Consecutive uremic RLS patients (n = 15) and idiopathic RLS patients (iRLS; n = 20) were evaluated. The groups were compared with respect to their clinical course, subjective symptoms [using the Pittsburgh Sleep Quality Index (PSQI) and the International Restless Legs Syndrome Severity Scale (IRLS)], polysomnographic (PSG) variables, the results of the suggested immobilization test (SIT), and the drug doses used to treat RLS. The duration of the disorder was significantly shorter in the uremic RLS group than in the iRLS group. The PSQI and IRLS scores before treatment were higher in the uremic RLS group than in the iRLS group. The periodic leg movement index (PLM index) on PSG and the SIT index were also higher in the uremic RLS group (P < 0.001, respectively). The bromocriptine equivalent dose of dopaminergic agonists used to treat RLS was significantly higher in the uremic RLS group (P < 0.001). Uremic RLS appears to deteriorate faster and to become more severe than iRLS. Moreover, uremic RLS patients appear to have a decreased response to dopaminergic agonists. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/18074382/Clinical_characteristics_of_restless_legs_syndrome_in_end_stage_renal_failure_and_idiopathic_RLS_patients_ L2 - https://doi.org/10.1002/mds.21882 DB - PRIME DP - Unbound Medicine ER -