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Oxidized low-density lipoprotein biomarkers in patients with end-stage renal failure: acute effects of hemodialysis.
Blood Purif 2007; 25(5-6):457-65BP

Abstract

OBJECTIVE

To assess the effect of end-stage renal failure on oxidized low-density lipoprotein (OxLDL) biomarkers and the acute effects of hemodialysis. Oxidized phospholipids (OxPL) on apolipoprotein B-100 (apoB) particles (OxPL/apoB) have been associated with cardiovascular disease and new cardiovascular events. Patients with end-stage renal failure have increased oxidative stress and are at significantly increased risk of cardiovascular disease.

METHODS AND RESULTS

Fifty-two stable patients with end-stage renal failure undergoing chronic hemodialysis were included in the study. Pre and post hemodialysis blood samples were obtained for measurement of OxLDL biomarkers: oxidized phospholipids (OxPL) on apolipoprotein B-100 (apoB) particles (OxPL/apoB) measured by antibody E06, IgG and IgM autoantibody titers to copper-oxidized LDL (Cu-OxLDL) and malondialdehyde (MDA)-LDL, IgG and IgM apolipoprotein B-100-immune complexes (IC/apoB). Traditional laboratory variables as well as C-reactive protein (CRP) and lipoprotein(a) [Lp(a)] were also measured. For the baseline variables, the distribution of OxPL/apoB and Lp(a) were skewed to lower values, and a strong correlation was noted between OxPL/apoB and Lp(a) (r = 0.94, p < 0.0001). No major associations were noted between OxLDL biomarkers and age, gender or dialytic age. There were also no correlations between OxLDL biomarkers and traditional risk factors, CRP, body mass index, serum creatinine, hypertension or intravenous iron therapy. Following dialysis, there as a significant reduction in OxPL/apoB (-7.5%, p = 0.048) and triglyceride levels (-10.8%, p = 0.005). All other OxLDL biomarkers, CRP, total cholesterol, LDL-C, HDL-C and apoB-100 increased significantly (range 6.3-26.9%, p value range 0.005 to <0.0001). Total protein plasma levels increased 8.8% (p = 0.014 compared to predialysis) following dialysis, consistent with a hemoconcentration effect of hemodialysis.

CONCLUSION

In end-stage renal failure patients undergoing hemodialysis, a reduction in OxPL/apoB levels was noted, despite the hemoconcentrating and strong pro-oxidant milieu of hemodialysis. Studies in larger populations of end-stage renal failure patients are needed to assess whether these findings predict future clinical outcomes.

Authors+Show Affiliations

Istituto di Clinica Chirurgica, Università Cattolica del Sacro Cuore, Roma, Italia. maubosso@tin.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

18075247

Citation

Bossola, Maurizio, et al. "Oxidized Low-density Lipoprotein Biomarkers in Patients With End-stage Renal Failure: Acute Effects of Hemodialysis." Blood Purification, vol. 25, no. 5-6, 2007, pp. 457-65.
Bossola M, Tazza L, Merki E, et al. Oxidized low-density lipoprotein biomarkers in patients with end-stage renal failure: acute effects of hemodialysis. Blood Purif. 2007;25(5-6):457-65.
Bossola, M., Tazza, L., Merki, E., Giungi, S., Luciani, G., Miller, E. R., ... Tsimikas, S. (2007). Oxidized low-density lipoprotein biomarkers in patients with end-stage renal failure: acute effects of hemodialysis. Blood Purification, 25(5-6), pp. 457-65.
Bossola M, et al. Oxidized Low-density Lipoprotein Biomarkers in Patients With End-stage Renal Failure: Acute Effects of Hemodialysis. Blood Purif. 2007;25(5-6):457-65. PubMed PMID: 18075247.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidized low-density lipoprotein biomarkers in patients with end-stage renal failure: acute effects of hemodialysis. AU - Bossola,Maurizio, AU - Tazza,Luigi, AU - Merki,Esther, AU - Giungi,Stefania, AU - Luciani,Giovanna, AU - Miller,Elizabeth R, AU - Lin,Edward B, AU - Tortorelli,Antonio, AU - Tsimikas,Sotirios, Y1 - 2007/12/13/ PY - 2007/08/08/received PY - 2007/10/09/accepted PY - 2007/12/14/pubmed PY - 2008/3/28/medline PY - 2007/12/14/entrez SP - 457 EP - 65 JF - Blood purification JO - Blood Purif. VL - 25 IS - 5-6 N2 - OBJECTIVE: To assess the effect of end-stage renal failure on oxidized low-density lipoprotein (OxLDL) biomarkers and the acute effects of hemodialysis. Oxidized phospholipids (OxPL) on apolipoprotein B-100 (apoB) particles (OxPL/apoB) have been associated with cardiovascular disease and new cardiovascular events. Patients with end-stage renal failure have increased oxidative stress and are at significantly increased risk of cardiovascular disease. METHODS AND RESULTS: Fifty-two stable patients with end-stage renal failure undergoing chronic hemodialysis were included in the study. Pre and post hemodialysis blood samples were obtained for measurement of OxLDL biomarkers: oxidized phospholipids (OxPL) on apolipoprotein B-100 (apoB) particles (OxPL/apoB) measured by antibody E06, IgG and IgM autoantibody titers to copper-oxidized LDL (Cu-OxLDL) and malondialdehyde (MDA)-LDL, IgG and IgM apolipoprotein B-100-immune complexes (IC/apoB). Traditional laboratory variables as well as C-reactive protein (CRP) and lipoprotein(a) [Lp(a)] were also measured. For the baseline variables, the distribution of OxPL/apoB and Lp(a) were skewed to lower values, and a strong correlation was noted between OxPL/apoB and Lp(a) (r = 0.94, p < 0.0001). No major associations were noted between OxLDL biomarkers and age, gender or dialytic age. There were also no correlations between OxLDL biomarkers and traditional risk factors, CRP, body mass index, serum creatinine, hypertension or intravenous iron therapy. Following dialysis, there as a significant reduction in OxPL/apoB (-7.5%, p = 0.048) and triglyceride levels (-10.8%, p = 0.005). All other OxLDL biomarkers, CRP, total cholesterol, LDL-C, HDL-C and apoB-100 increased significantly (range 6.3-26.9%, p value range 0.005 to <0.0001). Total protein plasma levels increased 8.8% (p = 0.014 compared to predialysis) following dialysis, consistent with a hemoconcentration effect of hemodialysis. CONCLUSION: In end-stage renal failure patients undergoing hemodialysis, a reduction in OxPL/apoB levels was noted, despite the hemoconcentrating and strong pro-oxidant milieu of hemodialysis. Studies in larger populations of end-stage renal failure patients are needed to assess whether these findings predict future clinical outcomes. SN - 1421-9735 UR - https://www.unboundmedicine.com/medline/citation/18075247/Oxidized_low_density_lipoprotein_biomarkers_in_patients_with_end_stage_renal_failure:_acute_effects_of_hemodialysis_ L2 - https://www.karger.com?DOI=10.1159/000112465 DB - PRIME DP - Unbound Medicine ER -