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[Immune factors or depression? Fatigue correlates in Parkinson's disease].
Rev Neurol. 2007 Dec 16-31; 45(12):725-8.RN

Abstract

INTRODUCTION

Fatigue is a frequent symptom in Parkinson disease (PD), but its pathogenesis remains obscure. Fatigue may be influenced by depression and motor disability, but immunological factors have been also implicated. The purpose of the study was to assess fatigue in PD patients in relation to depression and various immunological factors.

SUBJECTS AND METHODS

Forty PD patients and 26 normal matched controls were studied. Fatigue was assessed by the Fatigue Severity Scale (FSS). The Beck Depression Inventory (BDI) was employed for depression screening. The following immunological factors were estimated: a) T- and B-lymphocytes, T-lymphocyte subsets (helper/suppressor cells) as well as natural killer cells (NK); b) circulating levels of interleukins IL-1alpha, IL-1beta, IL-6, IL-1 receptor antagonist (IL-1Ra) and tumor necrosis factor-alpha.

RESULTS

FSS mean score was higher in PD patients compared to controls (p < 0.01). Significant differences between patients and controls were found in the following immunological parameters. In PD patients: a) mean percentage of NK cells was higher, p < 0.01); b) IL-1beta levels were significantly increased (p < 0.01) and IL-1Ra levels were decreased (p < 0.001). FSS correlated significantly to BDI (p < 0.008). Circulating Il-1Ra levels correlated to fatigue severity (p < 0.01), but after exclusion of depressed PD subjects this correlation significance level dropped to p = 0.055.

CONCLUSIONS

Our results indicate that fatigue is a common non motor symptom in PD. Immunological differences between PD patients and controls were observed in percentages of NK cells, IL-1beta and IL-1Ra blood levels. Fatigue correlated to depression and IL-Ra levels. However after exclusion of depressed subjects IL-1Ra levels showed only a tendency to significance, leaving depression as the principle correlate of fatigue.

Authors+Show Affiliations

Servicio de Neurología, Hospital Hippokration, Tesalónica, Grecia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

spa

PubMed ID

18075986

Citation

Katsarou, Z, et al. "[Immune Factors or Depression? Fatigue Correlates in Parkinson's Disease]." Revista De Neurologia, vol. 45, no. 12, 2007, pp. 725-8.
Katsarou Z, Bostantjopoulou S, Hatzizisi O, et al. [Immune factors or depression? Fatigue correlates in Parkinson's disease]. Rev Neurol. 2007;45(12):725-8.
Katsarou, Z., Bostantjopoulou, S., Hatzizisi, O., Giza, E., Soler-Cardona, A., & Kyriazis, G. (2007). [Immune factors or depression? Fatigue correlates in Parkinson's disease]. Revista De Neurologia, 45(12), 725-8.
Katsarou Z, et al. [Immune Factors or Depression? Fatigue Correlates in Parkinson's Disease]. Rev Neurol. 2007 Dec 16-31;45(12):725-8. PubMed PMID: 18075986.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Immune factors or depression? Fatigue correlates in Parkinson's disease]. AU - Katsarou,Z, AU - Bostantjopoulou,S, AU - Hatzizisi,O, AU - Giza,E, AU - Soler-Cardona,A, AU - Kyriazis,G, PY - 2007/12/14/pubmed PY - 2008/4/4/medline PY - 2007/12/14/entrez SP - 725 EP - 8 JF - Revista de neurologia JO - Rev Neurol VL - 45 IS - 12 N2 - INTRODUCTION: Fatigue is a frequent symptom in Parkinson disease (PD), but its pathogenesis remains obscure. Fatigue may be influenced by depression and motor disability, but immunological factors have been also implicated. The purpose of the study was to assess fatigue in PD patients in relation to depression and various immunological factors. SUBJECTS AND METHODS: Forty PD patients and 26 normal matched controls were studied. Fatigue was assessed by the Fatigue Severity Scale (FSS). The Beck Depression Inventory (BDI) was employed for depression screening. The following immunological factors were estimated: a) T- and B-lymphocytes, T-lymphocyte subsets (helper/suppressor cells) as well as natural killer cells (NK); b) circulating levels of interleukins IL-1alpha, IL-1beta, IL-6, IL-1 receptor antagonist (IL-1Ra) and tumor necrosis factor-alpha. RESULTS: FSS mean score was higher in PD patients compared to controls (p < 0.01). Significant differences between patients and controls were found in the following immunological parameters. In PD patients: a) mean percentage of NK cells was higher, p < 0.01); b) IL-1beta levels were significantly increased (p < 0.01) and IL-1Ra levels were decreased (p < 0.001). FSS correlated significantly to BDI (p < 0.008). Circulating Il-1Ra levels correlated to fatigue severity (p < 0.01), but after exclusion of depressed PD subjects this correlation significance level dropped to p = 0.055. CONCLUSIONS: Our results indicate that fatigue is a common non motor symptom in PD. Immunological differences between PD patients and controls were observed in percentages of NK cells, IL-1beta and IL-1Ra blood levels. Fatigue correlated to depression and IL-Ra levels. However after exclusion of depressed subjects IL-1Ra levels showed only a tendency to significance, leaving depression as the principle correlate of fatigue. SN - 0210-0010 UR - https://www.unboundmedicine.com/medline/citation/18075986/[Immune_factors_or_depression_Fatigue_correlates_in_Parkinson's_disease]_ L2 - http://www.revneurol.com/LinkOut/formMedLine.asp?Refer=2007496&amp;Revista=RevNeurol DB - PRIME DP - Unbound Medicine ER -