Tags

Type your tag names separated by a space and hit enter

Detection of new genotypes of Orientia tsutsugamushi infecting humans in Thailand.
Clin Microbiol Infect. 2008 Feb; 14(2):168-73.CM

Abstract

PCR screening of blood specimens taken from 195 patients with serologically confirmed scrub typhus in three Thai provinces detected the 56-kDa protein-encoding gene from Orientia tsutsugamushi in ten (5%) patients. Significant genetic diversity was found among the ten amplicons, with nine new genotypes identified that were different from those found previously in Thailand. Phylogenetically, the ten sequences obtained in the present study and sequences from 71 strains characterised previously were distributed into several clusters that included the Karp, Gilliam, Kuroki, Saitama, Kawasaki and Kato clusters. Two of the new genotypes found in the present study clearly belonged to the Karp cluster. However, the other new genotypes formed three different clusters, including one cluster that appeared to be distant from all previously known clusters, and which may therefore be representative of a previously undescribed serotype. Other genotypes formed two other clusters that may also be associated with undescribed serotypes.

Authors+Show Affiliations

Unité des Rickettsies, IFR 48, CNRS UMR6020, Faculté de Médecine, Université de la Méditerranée, Marseille, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18076670

Citation

Fournier, P-E, et al. "Detection of New Genotypes of Orientia Tsutsugamushi Infecting Humans in Thailand." Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, vol. 14, no. 2, 2008, pp. 168-73.
Fournier PE, Siritantikorn S, Rolain JM, et al. Detection of new genotypes of Orientia tsutsugamushi infecting humans in Thailand. Clin Microbiol Infect. 2008;14(2):168-73.
Fournier, P. E., Siritantikorn, S., Rolain, J. M., Suputtamongkol, Y., Hoontrakul, S., Charoenwat, S., Losuwanaluk, K., Parola, P., & Raoult, D. (2008). Detection of new genotypes of Orientia tsutsugamushi infecting humans in Thailand. Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 14(2), 168-73.
Fournier PE, et al. Detection of New Genotypes of Orientia Tsutsugamushi Infecting Humans in Thailand. Clin Microbiol Infect. 2008;14(2):168-73. PubMed PMID: 18076670.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection of new genotypes of Orientia tsutsugamushi infecting humans in Thailand. AU - Fournier,P-E, AU - Siritantikorn,S, AU - Rolain,J-M, AU - Suputtamongkol,Y, AU - Hoontrakul,S, AU - Charoenwat,S, AU - Losuwanaluk,K, AU - Parola,P, AU - Raoult,D, Y1 - 2007/12/10/ PY - 2007/12/14/pubmed PY - 2008/9/24/medline PY - 2007/12/14/entrez SP - 168 EP - 73 JF - Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases JO - Clin Microbiol Infect VL - 14 IS - 2 N2 - PCR screening of blood specimens taken from 195 patients with serologically confirmed scrub typhus in three Thai provinces detected the 56-kDa protein-encoding gene from Orientia tsutsugamushi in ten (5%) patients. Significant genetic diversity was found among the ten amplicons, with nine new genotypes identified that were different from those found previously in Thailand. Phylogenetically, the ten sequences obtained in the present study and sequences from 71 strains characterised previously were distributed into several clusters that included the Karp, Gilliam, Kuroki, Saitama, Kawasaki and Kato clusters. Two of the new genotypes found in the present study clearly belonged to the Karp cluster. However, the other new genotypes formed three different clusters, including one cluster that appeared to be distant from all previously known clusters, and which may therefore be representative of a previously undescribed serotype. Other genotypes formed two other clusters that may also be associated with undescribed serotypes. SN - 1198-743X UR - https://www.unboundmedicine.com/medline/citation/18076670/Detection_of_new_genotypes_of_Orientia_tsutsugamushi_infecting_humans_in_Thailand_ DB - PRIME DP - Unbound Medicine ER -