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Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women.
Hum Reprod 2008; 23(2):324-8HR

Abstract

BACKGROUND

Obesity is increasing rapidly among women all over the world. Obesity is a known risk factor for subfertility due to anovulation, but it is unknown whether obesity also affects spontaneous pregnancy chances in subfertile, ovulatory women.

METHODS

We evaluated whether obesity affected the chance of a spontaneous pregnancy in a prospectively assembled cohort of 3029 consecutive subfertile couples. Women had to be ovulatory and had to have at least one patent tube, whereas men had to have a normal semen analysis. Time to spontaneous ongoing pregnancy within 12 months was the primary endpoint.

RESULTS

The probability of a spontaneous pregnancy declined linearly with a body mass index (BMI) over 29 kg/m(2). Corrected for possible related factors, women with a high BMI had a 4% lower pregnancy rate per kg/m(2) increase [hazard ratio: 0.96 (95% CI 0.91-0.99)].

CONCLUSIONS

These results indicate that obesity is associated with lower pregnancy rates in subfertile ovulatory women.

Authors+Show Affiliations

Department of Public Health, Erasmus MC, University Medical Centre Rotterdam, The Netherlands. j.w.vandersteeg@amc.uva.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18077317

Citation

van der Steeg, Jan Willem, et al. "Obesity Affects Spontaneous Pregnancy Chances in Subfertile, Ovulatory Women." Human Reproduction (Oxford, England), vol. 23, no. 2, 2008, pp. 324-8.
van der Steeg JW, Steures P, Eijkemans MJ, et al. Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women. Hum Reprod. 2008;23(2):324-8.
van der Steeg, J. W., Steures, P., Eijkemans, M. J., Habbema, J. D., Hompes, P. G., Burggraaff, J. M., ... Mol, B. W. (2008). Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women. Human Reproduction (Oxford, England), 23(2), pp. 324-8.
van der Steeg JW, et al. Obesity Affects Spontaneous Pregnancy Chances in Subfertile, Ovulatory Women. Hum Reprod. 2008;23(2):324-8. PubMed PMID: 18077317.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women. AU - van der Steeg,Jan Willem, AU - Steures,Pieternel, AU - Eijkemans,Marinus J C, AU - Habbema,J Dik F, AU - Hompes,Peter G A, AU - Burggraaff,Jan M, AU - Oosterhuis,G Jur E, AU - Bossuyt,Patrick M M, AU - van der Veen,Fulco, AU - Mol,Ben W J, Y1 - 2007/12/11/ PY - 2007/12/14/pubmed PY - 2008/3/8/medline PY - 2007/12/14/entrez SP - 324 EP - 8 JF - Human reproduction (Oxford, England) JO - Hum. Reprod. VL - 23 IS - 2 N2 - BACKGROUND: Obesity is increasing rapidly among women all over the world. Obesity is a known risk factor for subfertility due to anovulation, but it is unknown whether obesity also affects spontaneous pregnancy chances in subfertile, ovulatory women. METHODS: We evaluated whether obesity affected the chance of a spontaneous pregnancy in a prospectively assembled cohort of 3029 consecutive subfertile couples. Women had to be ovulatory and had to have at least one patent tube, whereas men had to have a normal semen analysis. Time to spontaneous ongoing pregnancy within 12 months was the primary endpoint. RESULTS: The probability of a spontaneous pregnancy declined linearly with a body mass index (BMI) over 29 kg/m(2). Corrected for possible related factors, women with a high BMI had a 4% lower pregnancy rate per kg/m(2) increase [hazard ratio: 0.96 (95% CI 0.91-0.99)]. CONCLUSIONS: These results indicate that obesity is associated with lower pregnancy rates in subfertile ovulatory women. SN - 1460-2350 UR - https://www.unboundmedicine.com/medline/citation/18077317/full_citation L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/dem371 DB - PRIME DP - Unbound Medicine ER -