Abstract
Pharmacologic management of patients with narcolepsy is usually based on treating the separate symptoms of cataplexy and excessive daytime sleepiness (EDS). For treating cataplexy, the most widely used medications include the antidepressants venlafaxine, imipramine, and protriptyline, usually at lower doses than prescribed with depression, and sodium oxybate. Monoamine oxidase inhibitors are also sometimes used, but much less frequently. The U.S. Food and Drug Administration has approved 4 medications for EDS: dextroamphetamine, methylphenidate, modafinil, and sodium oxybate. Sodium oxybate is the only drug approved for treating both cataplexy and EDS. Modafinil and sodium oxybate have similar, long-term efficacies in treating EDS at prescribed doses.
TY - JOUR
T1 - Narcolepsy: treatment issues.
A1 - Roth,Thomas,
PY - 2007/12/19/pubmed
PY - 2008/1/8/medline
PY - 2007/12/19/entrez
SP - 16
EP - 9
JF - The Journal of clinical psychiatry
JO - J Clin Psychiatry
VL - 68 Suppl 13
N2 - Pharmacologic management of patients with narcolepsy is usually based on treating the separate symptoms of cataplexy and excessive daytime sleepiness (EDS). For treating cataplexy, the most widely used medications include the antidepressants venlafaxine, imipramine, and protriptyline, usually at lower doses than prescribed with depression, and sodium oxybate. Monoamine oxidase inhibitors are also sometimes used, but much less frequently. The U.S. Food and Drug Administration has approved 4 medications for EDS: dextroamphetamine, methylphenidate, modafinil, and sodium oxybate. Sodium oxybate is the only drug approved for treating both cataplexy and EDS. Modafinil and sodium oxybate have similar, long-term efficacies in treating EDS at prescribed doses.
SN - 1555-2101
UR - https://www.unboundmedicine.com/medline/citation/18078361/Narcolepsy:_treatment_issues_
L2 - http://www.psychiatrist.com/jcp/article/pages/2007/v68s13/v68s1304.aspx
DB - PRIME
DP - Unbound Medicine
ER -
