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Narcolepsy: treatment issues.
J Clin Psychiatry. 2007; 68 Suppl 13:16-9.JC

Abstract

Pharmacologic management of patients with narcolepsy is usually based on treating the separate symptoms of cataplexy and excessive daytime sleepiness (EDS). For treating cataplexy, the most widely used medications include the antidepressants venlafaxine, imipramine, and protriptyline, usually at lower doses than prescribed with depression, and sodium oxybate. Monoamine oxidase inhibitors are also sometimes used, but much less frequently. The U.S. Food and Drug Administration has approved 4 medications for EDS: dextroamphetamine, methylphenidate, modafinil, and sodium oxybate. Sodium oxybate is the only drug approved for treating both cataplexy and EDS. Modafinil and sodium oxybate have similar, long-term efficacies in treating EDS at prescribed doses.

Authors+Show Affiliations

Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI 48202, USA. Troth1@hfhs.org

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18078361

Citation

Roth, Thomas. "Narcolepsy: Treatment Issues." The Journal of Clinical Psychiatry, vol. 68 Suppl 13, 2007, pp. 16-9.
Roth T. Narcolepsy: treatment issues. J Clin Psychiatry. 2007;68 Suppl 13:16-9.
Roth, T. (2007). Narcolepsy: treatment issues. The Journal of Clinical Psychiatry, 68 Suppl 13, 16-9.
Roth T. Narcolepsy: Treatment Issues. J Clin Psychiatry. 2007;68 Suppl 13:16-9. PubMed PMID: 18078361.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Narcolepsy: treatment issues. A1 - Roth,Thomas, PY - 2007/12/19/pubmed PY - 2008/1/8/medline PY - 2007/12/19/entrez SP - 16 EP - 9 JF - The Journal of clinical psychiatry JO - J Clin Psychiatry VL - 68 Suppl 13 N2 - Pharmacologic management of patients with narcolepsy is usually based on treating the separate symptoms of cataplexy and excessive daytime sleepiness (EDS). For treating cataplexy, the most widely used medications include the antidepressants venlafaxine, imipramine, and protriptyline, usually at lower doses than prescribed with depression, and sodium oxybate. Monoamine oxidase inhibitors are also sometimes used, but much less frequently. The U.S. Food and Drug Administration has approved 4 medications for EDS: dextroamphetamine, methylphenidate, modafinil, and sodium oxybate. Sodium oxybate is the only drug approved for treating both cataplexy and EDS. Modafinil and sodium oxybate have similar, long-term efficacies in treating EDS at prescribed doses. SN - 1555-2101 UR - https://www.unboundmedicine.com/medline/citation/18078361/Narcolepsy:_treatment_issues_ L2 - http://www.psychiatrist.com/jcp/article/pages/2007/v68s13/v68s1304.aspx DB - PRIME DP - Unbound Medicine ER -