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Association between serum uric acid and the Adult Treatment Panel III-defined metabolic syndrome: results from a single hospital database.
Metabolism. 2008 Jan; 57(1):71-6.M

Abstract

Hyperuricemia is known to be associated with various metabolic abnormalities of the metabolic syndrome, but its precise contribution is not well defined. We have investigated the effects of serum uric acid on the metabolic syndrome as defined by the Adult Treatment Panel (ATP) III criteria and tested its independent association. This was a cross-sectional study consisting of 1686 Korean subjects (821 men and 865 women) from a health promotion center. Clinical data and the presence of the metabolic syndrome were assessed, and serum uric acid was tested for its independent contribution to the metabolic syndrome using 2 multiple logistic regression models. The metabolic syndrome was defined by the original ATP III criteria and the modified ATP III criteria that include a reduced waist circumference. The general age-adjusted prevalence of the metabolic syndrome was 4.4% in men and 6.8% in women; hyperuricemic subjects tended to have a higher prevalence of the metabolic syndrome and more metabolic abnormalities than normouricemic subjects. The prevalence of the metabolic syndrome increased as normouricemia (2.9%) progressed to hyperuricemia (8.9%) and to gout (43.6%) in men. Multivariate analysis showed that serum uric acid was a significant factor for the development of the metabolic syndrome as defined by the original ATP III criteria only in one model for women (odds ratio, 1.51; 95% confidence interval, 1.11-2.05; P = .009). Serum uric acid is closely linked to and may even be independently associated with the metabolic syndrome as defined by the ATP III criteria, but only in women.

Authors+Show Affiliations

Division of Rheumatology, Department of Internal Medicine, Korea University Medical School, Seoul 152-703, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18078861

Citation

Rho, Young Hee, et al. "Association Between Serum Uric Acid and the Adult Treatment Panel III-defined Metabolic Syndrome: Results From a Single Hospital Database." Metabolism: Clinical and Experimental, vol. 57, no. 1, 2008, pp. 71-6.
Rho YH, Woo JH, Choi SJ, et al. Association between serum uric acid and the Adult Treatment Panel III-defined metabolic syndrome: results from a single hospital database. Metab Clin Exp. 2008;57(1):71-6.
Rho, Y. H., Woo, J. H., Choi, S. J., Lee, Y. H., Ji, J. D., & Song, G. G. (2008). Association between serum uric acid and the Adult Treatment Panel III-defined metabolic syndrome: results from a single hospital database. Metabolism: Clinical and Experimental, 57(1), 71-6.
Rho YH, et al. Association Between Serum Uric Acid and the Adult Treatment Panel III-defined Metabolic Syndrome: Results From a Single Hospital Database. Metab Clin Exp. 2008;57(1):71-6. PubMed PMID: 18078861.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between serum uric acid and the Adult Treatment Panel III-defined metabolic syndrome: results from a single hospital database. AU - Rho,Young Hee, AU - Woo,Jin-Hyun, AU - Choi,Seong Jae, AU - Lee,Young Ho, AU - Ji,Jong Dae, AU - Song,Gwan Gyu, PY - 2007/01/09/received PY - 2007/08/07/accepted PY - 2007/12/15/pubmed PY - 2008/3/11/medline PY - 2007/12/15/entrez SP - 71 EP - 6 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 57 IS - 1 N2 - Hyperuricemia is known to be associated with various metabolic abnormalities of the metabolic syndrome, but its precise contribution is not well defined. We have investigated the effects of serum uric acid on the metabolic syndrome as defined by the Adult Treatment Panel (ATP) III criteria and tested its independent association. This was a cross-sectional study consisting of 1686 Korean subjects (821 men and 865 women) from a health promotion center. Clinical data and the presence of the metabolic syndrome were assessed, and serum uric acid was tested for its independent contribution to the metabolic syndrome using 2 multiple logistic regression models. The metabolic syndrome was defined by the original ATP III criteria and the modified ATP III criteria that include a reduced waist circumference. The general age-adjusted prevalence of the metabolic syndrome was 4.4% in men and 6.8% in women; hyperuricemic subjects tended to have a higher prevalence of the metabolic syndrome and more metabolic abnormalities than normouricemic subjects. The prevalence of the metabolic syndrome increased as normouricemia (2.9%) progressed to hyperuricemia (8.9%) and to gout (43.6%) in men. Multivariate analysis showed that serum uric acid was a significant factor for the development of the metabolic syndrome as defined by the original ATP III criteria only in one model for women (odds ratio, 1.51; 95% confidence interval, 1.11-2.05; P = .009). Serum uric acid is closely linked to and may even be independently associated with the metabolic syndrome as defined by the ATP III criteria, but only in women. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/18078861/Association_between_serum_uric_acid_and_the_Adult_Treatment_Panel_III_defined_metabolic_syndrome:_results_from_a_single_hospital_database_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(07)00294-6 DB - PRIME DP - Unbound Medicine ER -