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The relationship between plasma asymmetrical dimethyl-L-arginine and inflammation and adhesion molecule levels in subjects with normal, impaired, and diabetic glucose tolerance.
Metabolism. 2008 Jan; 57(1):110-5.M

Abstract

Increasing evidence suggests that the postprandial state is a contributing factor to the development of atherosclerosis. To evaluate the effects of acute hyperglycemia on endothelial dysfunction and inflammation, plasma asymmetrical dimethyl-l-arginine (ADMA), intercellular adhesion molecule 1 (sICAM-1), vascular cell adhesion molecule 1, and C-reactive protein (CRP) levels and secretory phospholipase A(2) (sPLA(2)) activities were measured in subjects with normal (n = 35), impaired (IGT) (n = 25), and diabetic (DGT) (n = 20) glucose tolerance. At baseline, plasma ADMA, sICAM-1, and CRP concentrations and plasma sPLA(2) activities were higher in both the IGT and DGT groups than in the normal glucose tolerance group (for each comparison, each P < .001). Patients with DGT have higher plasma ADMA and sICAM-1 concentrations than patients with IGT (for each, P < .001).Two hours after glucose loading, plasma ADMA and CRP concentrations and sPLA(2) activities were significantly elevated in the 3 groups when compared with baseline levels (for each comparison, P < .001). Plasma vascular cell adhesion molecule 1 and sICAM-1 concentrations were found to be elevated from baseline levels after glucose loading in the IGT and DGT groups (for each comparison, P < .001). Correlation analysis at baseline suggested that there was a significant relationship between ADMA and inflammation and soluble adhesion markers in the studied groups. In conclusion, plasma concentrations of ADMA and of inflammation and adhesion molecules were elevated in the prediabetic state. A complex interrelation could exist between ADMA and inflammation, and mechanisms involved in endothelial dysfunction are multifactorial at the prediabetic and diabetic state.

Authors+Show Affiliations

Istanbul University, Cerrahpasa Faculty of Medicine, Department of Biochemistry, Istanbul 34303, Turkey. dkonuk@istanbul.edu.trNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18078867

Citation

Konukoglu, Dildar, et al. "The Relationship Between Plasma Asymmetrical dimethyl-L-arginine and Inflammation and Adhesion Molecule Levels in Subjects With Normal, Impaired, and Diabetic Glucose Tolerance." Metabolism: Clinical and Experimental, vol. 57, no. 1, 2008, pp. 110-5.
Konukoglu D, Firtina S, Serin O. The relationship between plasma asymmetrical dimethyl-L-arginine and inflammation and adhesion molecule levels in subjects with normal, impaired, and diabetic glucose tolerance. Metabolism. 2008;57(1):110-5.
Konukoglu, D., Firtina, S., & Serin, O. (2008). The relationship between plasma asymmetrical dimethyl-L-arginine and inflammation and adhesion molecule levels in subjects with normal, impaired, and diabetic glucose tolerance. Metabolism: Clinical and Experimental, 57(1), 110-5.
Konukoglu D, Firtina S, Serin O. The Relationship Between Plasma Asymmetrical dimethyl-L-arginine and Inflammation and Adhesion Molecule Levels in Subjects With Normal, Impaired, and Diabetic Glucose Tolerance. Metabolism. 2008;57(1):110-5. PubMed PMID: 18078867.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship between plasma asymmetrical dimethyl-L-arginine and inflammation and adhesion molecule levels in subjects with normal, impaired, and diabetic glucose tolerance. AU - Konukoglu,Dildar, AU - Firtina,Sinem, AU - Serin,Ozden, PY - 2007/02/12/received PY - 2007/08/31/accepted PY - 2007/12/15/pubmed PY - 2008/3/11/medline PY - 2007/12/15/entrez SP - 110 EP - 5 JF - Metabolism: clinical and experimental JO - Metabolism VL - 57 IS - 1 N2 - Increasing evidence suggests that the postprandial state is a contributing factor to the development of atherosclerosis. To evaluate the effects of acute hyperglycemia on endothelial dysfunction and inflammation, plasma asymmetrical dimethyl-l-arginine (ADMA), intercellular adhesion molecule 1 (sICAM-1), vascular cell adhesion molecule 1, and C-reactive protein (CRP) levels and secretory phospholipase A(2) (sPLA(2)) activities were measured in subjects with normal (n = 35), impaired (IGT) (n = 25), and diabetic (DGT) (n = 20) glucose tolerance. At baseline, plasma ADMA, sICAM-1, and CRP concentrations and plasma sPLA(2) activities were higher in both the IGT and DGT groups than in the normal glucose tolerance group (for each comparison, each P < .001). Patients with DGT have higher plasma ADMA and sICAM-1 concentrations than patients with IGT (for each, P < .001).Two hours after glucose loading, plasma ADMA and CRP concentrations and sPLA(2) activities were significantly elevated in the 3 groups when compared with baseline levels (for each comparison, P < .001). Plasma vascular cell adhesion molecule 1 and sICAM-1 concentrations were found to be elevated from baseline levels after glucose loading in the IGT and DGT groups (for each comparison, P < .001). Correlation analysis at baseline suggested that there was a significant relationship between ADMA and inflammation and soluble adhesion markers in the studied groups. In conclusion, plasma concentrations of ADMA and of inflammation and adhesion molecules were elevated in the prediabetic state. A complex interrelation could exist between ADMA and inflammation, and mechanisms involved in endothelial dysfunction are multifactorial at the prediabetic and diabetic state. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/18078867/The_relationship_between_plasma_asymmetrical_dimethyl_L_arginine_and_inflammation_and_adhesion_molecule_levels_in_subjects_with_normal_impaired_and_diabetic_glucose_tolerance_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(07)00309-5 DB - PRIME DP - Unbound Medicine ER -