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Could ultraviolet B irradiance and vitamin D be associated with lower incidence rates of lung cancer?
J Epidemiol Community Health. 2008 Jan; 62(1):69-74.JE

Abstract

BACKGROUND

This study examines whether insufficient ultraviolet B (UVB) irradiance, a marker of vitamin D inadequacy, might contribute to lung cancer incidence.

METHODS

The association of latitude and UVB irradiance with age-adjusted incidence rates of lung cancer in 111 countries was investigated. Independent associations with UVB irradiance, cloud cover, anthropogenic aerosols, and cigarette smoking, were assessed using multiple regression.

RESULTS

Latitude was positively related to incidence rates in men (R(2) = 0.55, p<0.01) and women (R(2) = 0.36, p<0.01). In men, cigarette consumption (p<0.001) was positively related to risk, whereas UVB irradiance was inversely associated (p = 0.003). There were positive associations with UVB absorbers, in particular cloud cover (p = 0.05) and aerosol optical depth (p = 0.005). The R(2) for the model was 0.78 (p<0.001). UVB irradiance was also inversely associated with incidence rates in women (p = 0.0002), whereas cigarette consumption (p<0.001), total cloud cover (p = 0.02) and aerosol optical depth (p = 0.005) were positively associated. The R(2) for the model was 0.77 (p<0.001).

CONCLUSIONS

Lower levels of UVB irradiance were independently associated with higher incidence rates of lung cancer in 111 countries.

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    Authors+Show Affiliations

    Mohr SB
    Department of Family and Preventive Medicine 0631C, University of California San Diego, La Jolla, CA 92093, USA.
    Garland CF
    No affiliation info available
    Gorham ED
    No affiliation info available
    Grant WB
    No affiliation info available
    Garland FC
    No affiliation info available

    MeSH

    AerosolsAtmosphereEnvironmental ExposureEpidemiologic MethodsFemaleHumansLung NeoplasmsMaleSmokingSunlightUltraviolet RaysVitamin D Deficiency

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, Non-P.H.S.

    Language

    eng

    PubMed ID

    18079336

    Citation

    Mohr, S B., et al. "Could Ultraviolet B Irradiance and Vitamin D Be Associated With Lower Incidence Rates of Lung Cancer?" Journal of Epidemiology and Community Health, vol. 62, no. 1, 2008, pp. 69-74.
    Mohr SB, Garland CF, Gorham ED, et al. Could ultraviolet B irradiance and vitamin D be associated with lower incidence rates of lung cancer? J Epidemiol Community Health. 2008;62(1):69-74.
    Mohr, S. B., Garland, C. F., Gorham, E. D., Grant, W. B., & Garland, F. C. (2008). Could ultraviolet B irradiance and vitamin D be associated with lower incidence rates of lung cancer? Journal of Epidemiology and Community Health, 62(1), 69-74.
    Mohr SB, et al. Could Ultraviolet B Irradiance and Vitamin D Be Associated With Lower Incidence Rates of Lung Cancer. J Epidemiol Community Health. 2008;62(1):69-74. PubMed PMID: 18079336.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Could ultraviolet B irradiance and vitamin D be associated with lower incidence rates of lung cancer? AU - Mohr,S B, AU - Garland,C F, AU - Gorham,E D, AU - Grant,W B, AU - Garland,F C, PY - 2007/12/15/pubmed PY - 2008/7/25/medline PY - 2007/12/15/entrez SP - 69 EP - 74 JF - Journal of epidemiology and community health JO - J Epidemiol Community Health VL - 62 IS - 1 N2 - BACKGROUND: This study examines whether insufficient ultraviolet B (UVB) irradiance, a marker of vitamin D inadequacy, might contribute to lung cancer incidence. METHODS: The association of latitude and UVB irradiance with age-adjusted incidence rates of lung cancer in 111 countries was investigated. Independent associations with UVB irradiance, cloud cover, anthropogenic aerosols, and cigarette smoking, were assessed using multiple regression. RESULTS: Latitude was positively related to incidence rates in men (R(2) = 0.55, p<0.01) and women (R(2) = 0.36, p<0.01). In men, cigarette consumption (p<0.001) was positively related to risk, whereas UVB irradiance was inversely associated (p = 0.003). There were positive associations with UVB absorbers, in particular cloud cover (p = 0.05) and aerosol optical depth (p = 0.005). The R(2) for the model was 0.78 (p<0.001). UVB irradiance was also inversely associated with incidence rates in women (p = 0.0002), whereas cigarette consumption (p<0.001), total cloud cover (p = 0.02) and aerosol optical depth (p = 0.005) were positively associated. The R(2) for the model was 0.77 (p<0.001). CONCLUSIONS: Lower levels of UVB irradiance were independently associated with higher incidence rates of lung cancer in 111 countries. SN - 0143-005X UR - https://www.unboundmedicine.com/medline/citation/18079336/Could_ultraviolet_B_irradiance_and_vitamin_D_be_associated_with_lower_incidence_rates_of_lung_cancer L2 - http://jech.bmj.com/cgi/pmidlookup?view=long&amp;pmid=18079336 DB - PRIME DP - Unbound Medicine ER -