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Self-assembled micelles of biodegradable triblock copolymers based on poly(ethyl ethylene phosphate) and poly(-caprolactone) as drug carriers.
Biomacromolecules 2008; 9(1):388-95B

Abstract

A series of novel amphiphilic triblock copolymers of poly(ethyl ethylene phosphate) and poly(-caprolactone) (PEEP-PCL-PEEP) with various PEEP and PCL block lengths were synthesized and characterized. These triblock copolymers formed micelles composed of a hydrophobic core of poly(-caprolactone) (PCL) and a hydrophilic shell of poly(ethyl ethylene phosphate) (PEEP) in aqueous solution. The micelle morphology was spherical, determined by transmission electron microscopy. It was found that the size and critical micelle concentration values of the micelles depended on both hydrophobic PCL block length and PEEP hydrophilic block length. The in vitro degradation characteristics of the triblock copolymers were investigated in micellar form, showing that these copolymers were completely biodegradable under enzymatic catalysis of Pseudomonas lipase and phosphodiesterase I. These triblock copolymers were used for paclitaxel (PTX) encapsulation to demonstrate the potential in drug delivery. PTX was successfully loaded into the micelles, and the in vitro release profile was found to be correlative to the polymer composition. These biodegradable triblock copolymer micelles are potential as novel carriers for hydrophobic drug delivery.

Authors+Show Affiliations

Department of Polymer Science and Engineering, and Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18081252

Citation

Wang, Yu-Cai, et al. "Self-assembled Micelles of Biodegradable Triblock Copolymers Based On Poly(ethyl Ethylene Phosphate) and Poly(-caprolactone) as Drug Carriers." Biomacromolecules, vol. 9, no. 1, 2008, pp. 388-95.
Wang YC, Tang LY, Sun TM, et al. Self-assembled micelles of biodegradable triblock copolymers based on poly(ethyl ethylene phosphate) and poly(-caprolactone) as drug carriers. Biomacromolecules. 2008;9(1):388-95.
Wang, Y. C., Tang, L. Y., Sun, T. M., Li, C. H., Xiong, M. H., & Wang, J. (2008). Self-assembled micelles of biodegradable triblock copolymers based on poly(ethyl ethylene phosphate) and poly(-caprolactone) as drug carriers. Biomacromolecules, 9(1), pp. 388-95.
Wang YC, et al. Self-assembled Micelles of Biodegradable Triblock Copolymers Based On Poly(ethyl Ethylene Phosphate) and Poly(-caprolactone) as Drug Carriers. Biomacromolecules. 2008;9(1):388-95. PubMed PMID: 18081252.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Self-assembled micelles of biodegradable triblock copolymers based on poly(ethyl ethylene phosphate) and poly(-caprolactone) as drug carriers. AU - Wang,Yu-Cai, AU - Tang,Ling-Yan, AU - Sun,Tian-Meng, AU - Li,Chang-Hua, AU - Xiong,Meng-Hua, AU - Wang,Jun, Y1 - 2007/12/15/ PY - 2007/12/18/pubmed PY - 2008/4/1/medline PY - 2007/12/18/entrez SP - 388 EP - 95 JF - Biomacromolecules JO - Biomacromolecules VL - 9 IS - 1 N2 - A series of novel amphiphilic triblock copolymers of poly(ethyl ethylene phosphate) and poly(-caprolactone) (PEEP-PCL-PEEP) with various PEEP and PCL block lengths were synthesized and characterized. These triblock copolymers formed micelles composed of a hydrophobic core of poly(-caprolactone) (PCL) and a hydrophilic shell of poly(ethyl ethylene phosphate) (PEEP) in aqueous solution. The micelle morphology was spherical, determined by transmission electron microscopy. It was found that the size and critical micelle concentration values of the micelles depended on both hydrophobic PCL block length and PEEP hydrophilic block length. The in vitro degradation characteristics of the triblock copolymers were investigated in micellar form, showing that these copolymers were completely biodegradable under enzymatic catalysis of Pseudomonas lipase and phosphodiesterase I. These triblock copolymers were used for paclitaxel (PTX) encapsulation to demonstrate the potential in drug delivery. PTX was successfully loaded into the micelles, and the in vitro release profile was found to be correlative to the polymer composition. These biodegradable triblock copolymer micelles are potential as novel carriers for hydrophobic drug delivery. SN - 1526-4602 UR - https://www.unboundmedicine.com/medline/citation/18081252/Self_assembled_micelles_of_biodegradable_triblock_copolymers_based_on_poly_ethyl_ethylene_phosphate__and_poly__caprolactone__as_drug_carriers_ L2 - https://dx.doi.org/10.1021/bm700732g DB - PRIME DP - Unbound Medicine ER -