Tags

Type your tag names separated by a space and hit enter

Functional impairment of hematopoietic progenitor cells in patients with coronary heart disease.
Eur J Haematol. 2008 Mar; 80(3):258-64.EJ

Abstract

The circulating form of endothelial progenitors cells (EPCs) are derived from bone marrow (BM)-derived hematopoietic stem cells (HSCs). Enhanced mobilization of EPCs was shown to be linked to cardiac diseases. This study investigated whether reduced EPC levels in advanced coronary heart disease (CHD) are secondary to a functional exhaustion of HSCs in the BM or to reduced mobilization. Number and functional properties of EPCs were assessed in 15 healthy controls, and 40 patients with CHD. The colony-forming unit (CFU) capacity of BM-derived mononuclear cells and the CD34+ HSC number were examined in four healthy volunteers, and 15 CHD patients. EPC number was reduced in CHD patients (P < 0.01 vs. controls). Moreover, the migratory capacity was significantly impaired in EPCs of CHD patients (P < 0.05 vs. controls). On multivariate analysis, CHD was an independent predictor of functional EPC impairment. CFUs were reduced in CHD patients (59.6 +/- 21.2 vs. 75.4 +/- 25.8 in controls, P < 0.05). CHD was also predictor of impaired CFU capacity. In this small clinical study, CHD is associated with selective impairment of HSC function in the BM and in the peripheral blood, which may contribute to impairment of cardiac function.

Authors+Show Affiliations

Department of Cardiology-CCU, Hospital of Pellegrini-ASL NA1, Naples, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18081701

Citation

Liguori, Antonio, et al. "Functional Impairment of Hematopoietic Progenitor Cells in Patients With Coronary Heart Disease." European Journal of Haematology, vol. 80, no. 3, 2008, pp. 258-64.
Liguori A, Fiorito C, Balestrieri ML, et al. Functional impairment of hematopoietic progenitor cells in patients with coronary heart disease. Eur J Haematol. 2008;80(3):258-64.
Liguori, A., Fiorito, C., Balestrieri, M. L., Crimi, E., Bruzzese, G., Williams-Ignarro, S., D'Amora, M., Sommese, L., Grimaldi, V., Minucci, P. B., Giovane, A., Farzati, B., Ignarro, L. J., & Napoli, C. (2008). Functional impairment of hematopoietic progenitor cells in patients with coronary heart disease. European Journal of Haematology, 80(3), 258-64.
Liguori A, et al. Functional Impairment of Hematopoietic Progenitor Cells in Patients With Coronary Heart Disease. Eur J Haematol. 2008;80(3):258-64. PubMed PMID: 18081701.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Functional impairment of hematopoietic progenitor cells in patients with coronary heart disease. AU - Liguori,Antonio, AU - Fiorito,Carmela, AU - Balestrieri,Maria Luisa, AU - Crimi,Ettore, AU - Bruzzese,Giuseppe, AU - Williams-Ignarro,Sharon, AU - D'Amora,Maurizio, AU - Sommese,Linda, AU - Grimaldi,Vincenzo, AU - Minucci,Pellegrino Biagio, AU - Giovane,Alfonso, AU - Farzati,Bartolomeo, AU - Ignarro,Louis J, AU - Napoli,Claudio, Y1 - 2007/12/07/ PY - 2007/12/18/pubmed PY - 2008/3/4/medline PY - 2007/12/18/entrez SP - 258 EP - 64 JF - European journal of haematology JO - Eur J Haematol VL - 80 IS - 3 N2 - The circulating form of endothelial progenitors cells (EPCs) are derived from bone marrow (BM)-derived hematopoietic stem cells (HSCs). Enhanced mobilization of EPCs was shown to be linked to cardiac diseases. This study investigated whether reduced EPC levels in advanced coronary heart disease (CHD) are secondary to a functional exhaustion of HSCs in the BM or to reduced mobilization. Number and functional properties of EPCs were assessed in 15 healthy controls, and 40 patients with CHD. The colony-forming unit (CFU) capacity of BM-derived mononuclear cells and the CD34+ HSC number were examined in four healthy volunteers, and 15 CHD patients. EPC number was reduced in CHD patients (P < 0.01 vs. controls). Moreover, the migratory capacity was significantly impaired in EPCs of CHD patients (P < 0.05 vs. controls). On multivariate analysis, CHD was an independent predictor of functional EPC impairment. CFUs were reduced in CHD patients (59.6 +/- 21.2 vs. 75.4 +/- 25.8 in controls, P < 0.05). CHD was also predictor of impaired CFU capacity. In this small clinical study, CHD is associated with selective impairment of HSC function in the BM and in the peripheral blood, which may contribute to impairment of cardiac function. SN - 1600-0609 UR - https://www.unboundmedicine.com/medline/citation/18081701/Functional_impairment_of_hematopoietic_progenitor_cells_in_patients_with_coronary_heart_disease_ L2 - https://doi.org/10.1111/j.1600-0609.2007.01007.x DB - PRIME DP - Unbound Medicine ER -