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Serum resistin is positively correlated with the accumulation of metabolic syndrome factors in type 2 diabetes.
Clin Endocrinol (Oxf). 2008 Jul; 69(1):74-80.CE

Abstract

OBJECTIVE

Resistin, secreted from adipocytes, causes insulin resistance in rodents. We reported that the G/G genotype of a resistin gene promoter single nucleotide polymorphism (SNP) at -420 increases type 2 diabetes (T2DM) susceptibility by enhancing promoter activity. We also showed that serum resistin was positively correlated with G at SNP-420, the duration of T2DM, and HbA1c in T2DM. The aim of this study was to determine the relation between serum resistin and factors related to the metabolic syndrome (MetS) in T2DM.

DESIGN, PATIENTS AND MEASUREMENTS

We analysed 238 Japanese T2DM subjects (124 males and 114 females, age 60.2 +/- 11.3 years, body mass index (BMI) 24.1 +/- 3.9) whose overnight fasting sera were available. Serum resistin was measured using ELISA.

RESULTS

Serum resistin was higher in subjects with either obesity (P = 0.041), low HDL (P = 0.004), high triglycerides (TG) (P = 0.019), hypertension (HT) (P = 0.001) or atherosclerosis (P = 0.012). Simple regression analysis revealed that serum resistin was correlated with lower HDL, TG and high-sensitivity C-reactive protein (hsCRP). Multiple regression analysis (or logistic regression analysis for HT), adjusted for age, gender, BMI and the duration of T2DM, revealed that serum resistin was correlated with lower HDL (P = 0.008), TG (P = 0.041), HT (P = 0.031) and hsCRP (P = 0.004). Serum resistin was positively correlated with the number of MetS factors, independent of age, gender and the duration of T2DM (P < 0.001). Adjustment by either thiazolidinedione (TZD) treatment or hsCRP had no effects on these findings.

CONCLUSIONS

Serum resistin was positively correlated with the accumulation of MetS factors in T2DM.

Authors+Show Affiliations

Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Ehime Prefectural Hospital, Ehime, Japan. harosawa@m.ehime-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18081734

Citation

Osawa, Haruhiko, et al. "Serum Resistin Is Positively Correlated With the Accumulation of Metabolic Syndrome Factors in Type 2 Diabetes." Clinical Endocrinology, vol. 69, no. 1, 2008, pp. 74-80.
Osawa H, Ochi M, Tabara Y, et al. Serum resistin is positively correlated with the accumulation of metabolic syndrome factors in type 2 diabetes. Clin Endocrinol (Oxf). 2008;69(1):74-80.
Osawa, H., Ochi, M., Tabara, Y., Kato, K., Yamauchi, J., Takata, Y., Nishida, W., Onuma, H., Shimizu, I., Fujii, Y., Miki, T., Ohashi, J., & Makino, H. (2008). Serum resistin is positively correlated with the accumulation of metabolic syndrome factors in type 2 diabetes. Clinical Endocrinology, 69(1), 74-80.
Osawa H, et al. Serum Resistin Is Positively Correlated With the Accumulation of Metabolic Syndrome Factors in Type 2 Diabetes. Clin Endocrinol (Oxf). 2008;69(1):74-80. PubMed PMID: 18081734.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum resistin is positively correlated with the accumulation of metabolic syndrome factors in type 2 diabetes. AU - Osawa,Haruhiko, AU - Ochi,Masaaki, AU - Tabara,Yasuharu, AU - Kato,Kenichi, AU - Yamauchi,Junko, AU - Takata,Yasunori, AU - Nishida,Wataru, AU - Onuma,Hiroshi, AU - Shimizu,Ikki, AU - Fujii,Yasuhisa, AU - Miki,Tetsuro, AU - Ohashi,Jun, AU - Makino,Hideichi, Y1 - 2008/07/01/ PY - 2007/12/18/pubmed PY - 2009/7/25/medline PY - 2007/12/18/entrez SP - 74 EP - 80 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 69 IS - 1 N2 - OBJECTIVE: Resistin, secreted from adipocytes, causes insulin resistance in rodents. We reported that the G/G genotype of a resistin gene promoter single nucleotide polymorphism (SNP) at -420 increases type 2 diabetes (T2DM) susceptibility by enhancing promoter activity. We also showed that serum resistin was positively correlated with G at SNP-420, the duration of T2DM, and HbA1c in T2DM. The aim of this study was to determine the relation between serum resistin and factors related to the metabolic syndrome (MetS) in T2DM. DESIGN, PATIENTS AND MEASUREMENTS: We analysed 238 Japanese T2DM subjects (124 males and 114 females, age 60.2 +/- 11.3 years, body mass index (BMI) 24.1 +/- 3.9) whose overnight fasting sera were available. Serum resistin was measured using ELISA. RESULTS: Serum resistin was higher in subjects with either obesity (P = 0.041), low HDL (P = 0.004), high triglycerides (TG) (P = 0.019), hypertension (HT) (P = 0.001) or atherosclerosis (P = 0.012). Simple regression analysis revealed that serum resistin was correlated with lower HDL, TG and high-sensitivity C-reactive protein (hsCRP). Multiple regression analysis (or logistic regression analysis for HT), adjusted for age, gender, BMI and the duration of T2DM, revealed that serum resistin was correlated with lower HDL (P = 0.008), TG (P = 0.041), HT (P = 0.031) and hsCRP (P = 0.004). Serum resistin was positively correlated with the number of MetS factors, independent of age, gender and the duration of T2DM (P < 0.001). Adjustment by either thiazolidinedione (TZD) treatment or hsCRP had no effects on these findings. CONCLUSIONS: Serum resistin was positively correlated with the accumulation of MetS factors in T2DM. SN - 1365-2265 UR - https://www.unboundmedicine.com/medline/citation/18081734/Serum_resistin_is_positively_correlated_with_the_accumulation_of_metabolic_syndrome_factors_in_type_2_diabetes_ L2 - https://doi.org/10.1111/j.1365-2265.2007.03154.x DB - PRIME DP - Unbound Medicine ER -