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Interactions of wine drinking with omega-3 fatty acids in patients with coronary heart disease: a fish-like effect of moderate wine drinking.
Am Heart J. 2008 Jan; 155(1):175-81.AH

Abstract

BACKGROUND

Moderate alcohol drinking and marine omega-3 fatty acids (omega3) have both been associated with low mortality from coronary heart disease (CHD). However, there is little data evaluating the interactions of wine ethanol drinking with omega3 in CHD patients.

METHODS

The relationships between wine drinking and marine omega3 were evaluated in a cross-sectional study in patients with CHD participating in a randomized trial testing the effect of a high alpha-linolenic acid (ALA, the main plant omega3) diet. Daily ethanol intake was calculated as energy and expressed as a percentage of total energy. Plant and marine omega3 in the diet were carefully evaluated in each patient in both groups.

RESULTS

Patients were classified according to their habitual consumption of ethanol. Patients in the "high ALA group" and controls ("low ALA group") were analyzed separately. Within each group, there was a progressive increase in marine omega3 levels with increased alcohol intake, with a level of eicosapentanoic acid (EPA) that increased by 50% (P < .005) and 37% (P < .05) in the low and high ALA groups, respectively. After controlling for potential confounders (including dietary EPA) in a multivariate linear model, the association between wine ethanol and EPA remained significant in the low (P < .001) and high (P < .05) ALA groups.

CONCLUSION

In these patients with CHD, moderate wine drinking was associated with higher marine omega3 concentrations than no alcohol use. Although the data have to be confirmed in large groups, this effect of wine comparable to that of fish may partly explain the protective effects of wine drinking against CHD.

Authors+Show Affiliations

Laboratoire Coeur et Nutrition, PRETA-TIMC-IMAG, Faculté de Médecine, Université Joseph Fourier de Grenoble, Grenoble, France. michel.delorgeril@ujf-grenoble.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18082510

Citation

de Lorgeril, Michel, et al. "Interactions of Wine Drinking With Omega-3 Fatty Acids in Patients With Coronary Heart Disease: a Fish-like Effect of Moderate Wine Drinking." American Heart Journal, vol. 155, no. 1, 2008, pp. 175-81.
de Lorgeril M, Salen P, Martin JL, et al. Interactions of wine drinking with omega-3 fatty acids in patients with coronary heart disease: a fish-like effect of moderate wine drinking. Am Heart J. 2008;155(1):175-81.
de Lorgeril, M., Salen, P., Martin, J. L., Boucher, F., & de Leiris, J. (2008). Interactions of wine drinking with omega-3 fatty acids in patients with coronary heart disease: a fish-like effect of moderate wine drinking. American Heart Journal, 155(1), 175-81.
de Lorgeril M, et al. Interactions of Wine Drinking With Omega-3 Fatty Acids in Patients With Coronary Heart Disease: a Fish-like Effect of Moderate Wine Drinking. Am Heart J. 2008;155(1):175-81. PubMed PMID: 18082510.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interactions of wine drinking with omega-3 fatty acids in patients with coronary heart disease: a fish-like effect of moderate wine drinking. AU - de Lorgeril,Michel, AU - Salen,Patricia, AU - Martin,Jean-Louis, AU - Boucher,François, AU - de Leiris,Joël, Y1 - 2007/09/27/ PY - 2007/06/08/received PY - 2007/08/12/accepted PY - 2007/12/18/pubmed PY - 2008/1/11/medline PY - 2007/12/18/entrez SP - 175 EP - 81 JF - American heart journal JO - Am Heart J VL - 155 IS - 1 N2 - BACKGROUND: Moderate alcohol drinking and marine omega-3 fatty acids (omega3) have both been associated with low mortality from coronary heart disease (CHD). However, there is little data evaluating the interactions of wine ethanol drinking with omega3 in CHD patients. METHODS: The relationships between wine drinking and marine omega3 were evaluated in a cross-sectional study in patients with CHD participating in a randomized trial testing the effect of a high alpha-linolenic acid (ALA, the main plant omega3) diet. Daily ethanol intake was calculated as energy and expressed as a percentage of total energy. Plant and marine omega3 in the diet were carefully evaluated in each patient in both groups. RESULTS: Patients were classified according to their habitual consumption of ethanol. Patients in the "high ALA group" and controls ("low ALA group") were analyzed separately. Within each group, there was a progressive increase in marine omega3 levels with increased alcohol intake, with a level of eicosapentanoic acid (EPA) that increased by 50% (P < .005) and 37% (P < .05) in the low and high ALA groups, respectively. After controlling for potential confounders (including dietary EPA) in a multivariate linear model, the association between wine ethanol and EPA remained significant in the low (P < .001) and high (P < .05) ALA groups. CONCLUSION: In these patients with CHD, moderate wine drinking was associated with higher marine omega3 concentrations than no alcohol use. Although the data have to be confirmed in large groups, this effect of wine comparable to that of fish may partly explain the protective effects of wine drinking against CHD. SN - 1097-6744 UR - https://www.unboundmedicine.com/medline/citation/18082510/Interactions_of_wine_drinking_with_omega_3_fatty_acids_in_patients_with_coronary_heart_disease:_a_fish_like_effect_of_moderate_wine_drinking_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-8703(07)00684-9 DB - PRIME DP - Unbound Medicine ER -