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Nano/micro technologies for delivering macromolecular therapeutics using poly(D,L-lactide-co-glycolide) and its derivatives.
J Control Release. 2008 Feb 11; 125(3):193-209.JC

Abstract

Biodegradable nano/microparticles of poly(D,L-lactide-co-glycolide) (PLGA) and PLGA-based polymers are widely explored as carriers for controlled delivery of macromolecular therapeutics such as proteins, peptides, vaccines, genes, antigens, growth factors, etc. These devices are mainly produced by emulsion or double-emulsion technique followed by solvent evaporation or spray drying. Drug encapsulation, particle size, additives added during formulation, molecular weight, ratio of lactide to glycolide moieties in PLGA and surface morphology could influence the release characteristics. Encapsulation efficiency and release rates through nano/microparticle-mediated drug delivery devices can be optimized to improve their therapeutic efficacy. In this review, important findings of the past decade on the encapsulation and release profiles of macromolecular therapeutics from PLGA and PLGA-based nano/microparticles are discussed critically in relation to nature and type of bioactive molecule, carrier polymer and experimental variables that influence the delivery of macromolecular therapeutics. Even though extensive research on biodegradable microparticles containing macromolecular drugs has greatly advanced to the level of production know-how, the effects of critical parameters influencing drug encapsulation are not sufficiently investigated for nano-scaled carriers. The present review attempts to address some important data on nano/microparticle-based delivery systems of PLGA and PLGA-derived polymers with reference to macromolecular drugs.

Authors+Show Affiliations

Industrial Biotechnology Group, Reliance Life Sciences Pvt. Ltd., Dhirubhai Ambani Life Sciences Centre, Thane Belapur Road, Rabale, Navi Mumbai 400 701, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18083265

Citation

Mundargi, Raghavendra C., et al. "Nano/micro Technologies for Delivering Macromolecular Therapeutics Using poly(D,L-lactide-co-glycolide) and Its Derivatives." Journal of Controlled Release : Official Journal of the Controlled Release Society, vol. 125, no. 3, 2008, pp. 193-209.
Mundargi RC, Babu VR, Rangaswamy V, et al. Nano/micro technologies for delivering macromolecular therapeutics using poly(D,L-lactide-co-glycolide) and its derivatives. J Control Release. 2008;125(3):193-209.
Mundargi, R. C., Babu, V. R., Rangaswamy, V., Patel, P., & Aminabhavi, T. M. (2008). Nano/micro technologies for delivering macromolecular therapeutics using poly(D,L-lactide-co-glycolide) and its derivatives. Journal of Controlled Release : Official Journal of the Controlled Release Society, 125(3), 193-209.
Mundargi RC, et al. Nano/micro Technologies for Delivering Macromolecular Therapeutics Using poly(D,L-lactide-co-glycolide) and Its Derivatives. J Control Release. 2008 Feb 11;125(3):193-209. PubMed PMID: 18083265.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nano/micro technologies for delivering macromolecular therapeutics using poly(D,L-lactide-co-glycolide) and its derivatives. AU - Mundargi,Raghavendra C, AU - Babu,V Ramesh, AU - Rangaswamy,Vidhya, AU - Patel,Pradip, AU - Aminabhavi,Tejraj M, Y1 - 2007/10/22/ PY - 2007/07/24/received PY - 2007/09/27/accepted PY - 2007/12/18/pubmed PY - 2008/3/19/medline PY - 2007/12/18/entrez SP - 193 EP - 209 JF - Journal of controlled release : official journal of the Controlled Release Society JO - J Control Release VL - 125 IS - 3 N2 - Biodegradable nano/microparticles of poly(D,L-lactide-co-glycolide) (PLGA) and PLGA-based polymers are widely explored as carriers for controlled delivery of macromolecular therapeutics such as proteins, peptides, vaccines, genes, antigens, growth factors, etc. These devices are mainly produced by emulsion or double-emulsion technique followed by solvent evaporation or spray drying. Drug encapsulation, particle size, additives added during formulation, molecular weight, ratio of lactide to glycolide moieties in PLGA and surface morphology could influence the release characteristics. Encapsulation efficiency and release rates through nano/microparticle-mediated drug delivery devices can be optimized to improve their therapeutic efficacy. In this review, important findings of the past decade on the encapsulation and release profiles of macromolecular therapeutics from PLGA and PLGA-based nano/microparticles are discussed critically in relation to nature and type of bioactive molecule, carrier polymer and experimental variables that influence the delivery of macromolecular therapeutics. Even though extensive research on biodegradable microparticles containing macromolecular drugs has greatly advanced to the level of production know-how, the effects of critical parameters influencing drug encapsulation are not sufficiently investigated for nano-scaled carriers. The present review attempts to address some important data on nano/microparticle-based delivery systems of PLGA and PLGA-derived polymers with reference to macromolecular drugs. SN - 1873-4995 UR - https://www.unboundmedicine.com/medline/citation/18083265/Nano/micro_technologies_for_delivering_macromolecular_therapeutics_using_poly_DL_lactide_co_glycolide__and_its_derivatives_ DB - PRIME DP - Unbound Medicine ER -