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Apomorphine for the acute treatment of "off" episodes in Parkinson's disease.
Parkinsonism Relat Disord. 2008; 14(2):85-92.PR

Abstract

Many patients with advanced Parkinson's disease (PD) experience motor complications, which negatively impact quality of life, despite optimized oral therapy. It is important for patients to have a treatment option that may provide rapid relief from "off" episodes. In three pivotal, randomized, placebo-controlled trials, subcutaneous apomorphine was effective in acutely treating "off" episodes, significantly improving Unified Parkinson Disease Rating Scale motor scores and reducing the number of "off" hours per day, with a significantly shorter time to patient-declared onset of relief than placebo. Thus, clinical trial data support the efficacy of intermittent subcutaneous apomorphine as a rapid acute treatment for "off" episodes in advanced PD.

Authors+Show Affiliations

Division of Neurology, Duke University, 932 Morreene Road, MS 3333, Durham, NC27705, USA. mark.stacy@duke.edu <mark.stacy@duke.edu>No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18083605

Citation

Stacy, Mark, and Dee Silver. "Apomorphine for the Acute Treatment of "off" Episodes in Parkinson's Disease." Parkinsonism & Related Disorders, vol. 14, no. 2, 2008, pp. 85-92.
Stacy M, Silver D. Apomorphine for the acute treatment of "off" episodes in Parkinson's disease. Parkinsonism Relat Disord. 2008;14(2):85-92.
Stacy, M., & Silver, D. (2008). Apomorphine for the acute treatment of "off" episodes in Parkinson's disease. Parkinsonism & Related Disorders, 14(2), 85-92.
Stacy M, Silver D. Apomorphine for the Acute Treatment of "off" Episodes in Parkinson's Disease. Parkinsonism Relat Disord. 2008;14(2):85-92. PubMed PMID: 18083605.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apomorphine for the acute treatment of "off" episodes in Parkinson's disease. AU - Stacy,Mark, AU - Silver,Dee, Y1 - 2007/12/21/ PY - 2007/02/07/received PY - 2007/07/13/revised PY - 2007/07/18/accepted PY - 2007/12/18/pubmed PY - 2008/5/29/medline PY - 2007/12/18/entrez SP - 85 EP - 92 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 14 IS - 2 N2 - Many patients with advanced Parkinson's disease (PD) experience motor complications, which negatively impact quality of life, despite optimized oral therapy. It is important for patients to have a treatment option that may provide rapid relief from "off" episodes. In three pivotal, randomized, placebo-controlled trials, subcutaneous apomorphine was effective in acutely treating "off" episodes, significantly improving Unified Parkinson Disease Rating Scale motor scores and reducing the number of "off" hours per day, with a significantly shorter time to patient-declared onset of relief than placebo. Thus, clinical trial data support the efficacy of intermittent subcutaneous apomorphine as a rapid acute treatment for "off" episodes in advanced PD. SN - 1353-8020 UR - https://www.unboundmedicine.com/medline/citation/18083605/Apomorphine_for_the_acute_treatment_of_"off"_episodes_in_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(07)00127-7 DB - PRIME DP - Unbound Medicine ER -