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[Bronchial hyperresponsiveness to histamine induced by intravenous administration of thromboxane A2 (TXA2) in guinea-pigs].
Nihon Kyobu Shikkan Gakkai Zasshi. 1991 Dec; 29(12):1532-7.NK

Abstract

Thromboxane A2 (TXA2) has been suggested to play an important role in the pathogenesis of bronchial asthma. In this study the effects of intravenous administration of TXA2 on bronchial smooth muscle in guinea-pigs were investigated by measuring dynamic compliance and dynamic respiratory resistance, using a formula to exclude the effects of differences in airway wall thickness. Using this formula, the ratio of bronchial smooth muscle constriction by histamine can be estimated as an index of bronchial hyperresponsiveness. Administration of TXA2 did not induce airway wall edema. The ratio of bronchial smooth muscle constriction by histamine was significantly (p less than 0.01) enhanced by the administration of TXA2. Moreover, TXA2 antagonists, ONO-NT-126 and ONO-8809, inhibited the effect of TXA2 administration. These results suggest that TXA2 is an important mediator affecting bronchial hyperresponsiveness.

Authors+Show Affiliations

First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.No affiliation info available

Pub Type(s)

Journal Article

Language

jpn

PubMed ID

1808375

Citation

Tsukagoshi, H, and M Kurosawa. "[Bronchial Hyperresponsiveness to Histamine Induced By Intravenous Administration of Thromboxane A2 (TXA2) in Guinea-pigs]." Nihon Kyobu Shikkan Gakkai Zasshi, vol. 29, no. 12, 1991, pp. 1532-7.
Tsukagoshi H, Kurosawa M. [Bronchial hyperresponsiveness to histamine induced by intravenous administration of thromboxane A2 (TXA2) in guinea-pigs]. Nihon Kyobu Shikkan Gakkai Zasshi. 1991;29(12):1532-7.
Tsukagoshi, H., & Kurosawa, M. (1991). [Bronchial hyperresponsiveness to histamine induced by intravenous administration of thromboxane A2 (TXA2) in guinea-pigs]. Nihon Kyobu Shikkan Gakkai Zasshi, 29(12), 1532-7.
Tsukagoshi H, Kurosawa M. [Bronchial Hyperresponsiveness to Histamine Induced By Intravenous Administration of Thromboxane A2 (TXA2) in Guinea-pigs]. Nihon Kyobu Shikkan Gakkai Zasshi. 1991;29(12):1532-7. PubMed PMID: 1808375.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Bronchial hyperresponsiveness to histamine induced by intravenous administration of thromboxane A2 (TXA2) in guinea-pigs]. AU - Tsukagoshi,H, AU - Kurosawa,M, PY - 1991/12/1/pubmed PY - 1991/12/1/medline PY - 1991/12/1/entrez SP - 1532 EP - 7 JF - Nihon Kyobu Shikkan Gakkai zasshi JO - Nihon Kyobu Shikkan Gakkai Zasshi VL - 29 IS - 12 N2 - Thromboxane A2 (TXA2) has been suggested to play an important role in the pathogenesis of bronchial asthma. In this study the effects of intravenous administration of TXA2 on bronchial smooth muscle in guinea-pigs were investigated by measuring dynamic compliance and dynamic respiratory resistance, using a formula to exclude the effects of differences in airway wall thickness. Using this formula, the ratio of bronchial smooth muscle constriction by histamine can be estimated as an index of bronchial hyperresponsiveness. Administration of TXA2 did not induce airway wall edema. The ratio of bronchial smooth muscle constriction by histamine was significantly (p less than 0.01) enhanced by the administration of TXA2. Moreover, TXA2 antagonists, ONO-NT-126 and ONO-8809, inhibited the effect of TXA2 administration. These results suggest that TXA2 is an important mediator affecting bronchial hyperresponsiveness. SN - 0301-1542 UR - https://www.unboundmedicine.com/medline/citation/1808375/[Bronchial_hyperresponsiveness_to_histamine_induced_by_intravenous_administration_of_thromboxane_A2__TXA2__in_guinea_pigs]_ L2 - https://medlineplus.gov/asthma.html DB - PRIME DP - Unbound Medicine ER -