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Human intestinal spirochetosis in Japan; its incidence, clinicopathologic features, and genotypic identification.
Mod Pathol. 2008 Feb; 21(2):76-84.MP

Abstract

Human intestinal spirochetosis is a common condition in Western countries, but is not well recognized in Japan. To demonstrate the incidence and clinicopathologic findings of human intestinal spirochetosis in Japan, we retrospectively investigated biopsy, and endoscopically or surgically resected specimens of the large intestine. Among a series of 2556 samples, 11 cases of human intestinal spirochetosis were detected (0.4%). Together with additional nine cases sporadically found, 20 cases of human intestinal spirochetosis were subjected to molecular detection of two strains of spirochetes (Brachyspira aalborgi and Brachyspira pilosicoli) by amplifying species-specific portion of 16S ribosomal RNA and NADH oxydase gene by polymerase chain reaction. B. aalborgi was detected in all cases examined, three of which revealed dual infection of both species. Our results suggest that human intestinal spirochetosis infection is relatively rare, and B. aalborgi is the most prevalent species in Japan. Most of human intestinal spirochetosis were asymptomatic, although symptomatic in exceptional cases. In addition, we emphasize a usefulness of immunostaining with anti-Treponema pallidum and anti-Mycobacterium bovis polyclonal antibodies for detecting the spirochetes.

Authors+Show Affiliations

Department of Pathology, Faculty of Medicine, Oita University, Yufu, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18084255

Citation

Tanahashi, Jin, et al. "Human Intestinal Spirochetosis in Japan; Its Incidence, Clinicopathologic Features, and Genotypic Identification." Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, vol. 21, no. 2, 2008, pp. 76-84.
Tanahashi J, Daa T, Gamachi A, et al. Human intestinal spirochetosis in Japan; its incidence, clinicopathologic features, and genotypic identification. Mod Pathol. 2008;21(2):76-84.
Tanahashi, J., Daa, T., Gamachi, A., Kashima, K., Kondoh, Y., Yada, N., & Yokoyama, S. (2008). Human intestinal spirochetosis in Japan; its incidence, clinicopathologic features, and genotypic identification. Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 21(2), 76-84.
Tanahashi J, et al. Human Intestinal Spirochetosis in Japan; Its Incidence, Clinicopathologic Features, and Genotypic Identification. Mod Pathol. 2008;21(2):76-84. PubMed PMID: 18084255.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human intestinal spirochetosis in Japan; its incidence, clinicopathologic features, and genotypic identification. AU - Tanahashi,Jin, AU - Daa,Tsutomu, AU - Gamachi,Ayako, AU - Kashima,Kenji, AU - Kondoh,Yoshiyuki, AU - Yada,Naomi, AU - Yokoyama,Shigeo, Y1 - 2007/12/14/ PY - 2007/12/18/pubmed PY - 2008/4/30/medline PY - 2007/12/18/entrez SP - 76 EP - 84 JF - Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc JO - Mod Pathol VL - 21 IS - 2 N2 - Human intestinal spirochetosis is a common condition in Western countries, but is not well recognized in Japan. To demonstrate the incidence and clinicopathologic findings of human intestinal spirochetosis in Japan, we retrospectively investigated biopsy, and endoscopically or surgically resected specimens of the large intestine. Among a series of 2556 samples, 11 cases of human intestinal spirochetosis were detected (0.4%). Together with additional nine cases sporadically found, 20 cases of human intestinal spirochetosis were subjected to molecular detection of two strains of spirochetes (Brachyspira aalborgi and Brachyspira pilosicoli) by amplifying species-specific portion of 16S ribosomal RNA and NADH oxydase gene by polymerase chain reaction. B. aalborgi was detected in all cases examined, three of which revealed dual infection of both species. Our results suggest that human intestinal spirochetosis infection is relatively rare, and B. aalborgi is the most prevalent species in Japan. Most of human intestinal spirochetosis were asymptomatic, although symptomatic in exceptional cases. In addition, we emphasize a usefulness of immunostaining with anti-Treponema pallidum and anti-Mycobacterium bovis polyclonal antibodies for detecting the spirochetes. SN - 0893-3952 UR - https://www.unboundmedicine.com/medline/citation/18084255/Human_intestinal_spirochetosis_in_Japan DB - PRIME DP - Unbound Medicine ER -