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Metabolic syndrome and non-alcoholic fatty liver disease: Asian definitions and Asian studies.
Hepatobiliary Pancreat Dis Int. 2007 Dec; 6(6):572-8.HP

Abstract

BACKGROUND

Non-alcoholic fatty liver disease (NAFLD), as conventionally recognized, is a metabolic disorder largely confined to residents of affluent industrialized Western countries. However, obesity and insulin resistance are not restricted to the West, as witnessed by their increasingly universal distribution. In particular, there has been an upsurge in metabolic syndrome in the Asia-Pacific region, although there are critical differences in the extent of adiposity between Eastern and Western populations.

DATA SOURCES

An English-language literature search using PubMed (1999-2007) on obesity, metabolic syndrome and NAFLD, focusing on Asian definitions and Asian studies.

RESULTS

NAFLD appears to be of long-standing insulin resistance and likely represents the hepatic manifestation of the metabolic syndrome. With insulin resistance as a common factor, the disease is associated with atherosclerosis and cardiovascular risk. All features of the metabolic syndrome and related events are assessed for practical management of NAFLD, although the criteria for the diagnosis of obesity and central obesity differ across racial groups.

CONCLUSIONS

The increasing prevalence of obesity, coupled with diabetes, dyslipidemia, hypertension and ultimately metabolic syndrome, puts a very large population at risk of developing NAFLD in the coming decades. The simultaneous identification and appropriate treatment of the components of metabolic syndrome are crucial to reduce hepatic as well as cardiovascular morbidity and mortality.

Authors+Show Affiliations

Center for Fatty Liver Disease & Department of Endocrinology, Shanghai First People's Hospital, Jiaotong University, Shanghai 200080, China. fanjiangao@gmail.comNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18086620

Citation

Fan, Jian-Gao, and Yong-De Peng. "Metabolic Syndrome and Non-alcoholic Fatty Liver Disease: Asian Definitions and Asian Studies." Hepatobiliary & Pancreatic Diseases International : HBPD INT, vol. 6, no. 6, 2007, pp. 572-8.
Fan JG, Peng YD. Metabolic syndrome and non-alcoholic fatty liver disease: Asian definitions and Asian studies. HBPD INT. 2007;6(6):572-8.
Fan, J. G., & Peng, Y. D. (2007). Metabolic syndrome and non-alcoholic fatty liver disease: Asian definitions and Asian studies. Hepatobiliary & Pancreatic Diseases International : HBPD INT, 6(6), 572-8.
Fan JG, Peng YD. Metabolic Syndrome and Non-alcoholic Fatty Liver Disease: Asian Definitions and Asian Studies. HBPD INT. 2007;6(6):572-8. PubMed PMID: 18086620.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic syndrome and non-alcoholic fatty liver disease: Asian definitions and Asian studies. AU - Fan,Jian-Gao, AU - Peng,Yong-De, PY - 2007/12/19/pubmed PY - 2008/2/22/medline PY - 2007/12/19/entrez SP - 572 EP - 8 JF - Hepatobiliary & pancreatic diseases international : HBPD INT JO - HBPD INT VL - 6 IS - 6 N2 - BACKGROUND: Non-alcoholic fatty liver disease (NAFLD), as conventionally recognized, is a metabolic disorder largely confined to residents of affluent industrialized Western countries. However, obesity and insulin resistance are not restricted to the West, as witnessed by their increasingly universal distribution. In particular, there has been an upsurge in metabolic syndrome in the Asia-Pacific region, although there are critical differences in the extent of adiposity between Eastern and Western populations. DATA SOURCES: An English-language literature search using PubMed (1999-2007) on obesity, metabolic syndrome and NAFLD, focusing on Asian definitions and Asian studies. RESULTS: NAFLD appears to be of long-standing insulin resistance and likely represents the hepatic manifestation of the metabolic syndrome. With insulin resistance as a common factor, the disease is associated with atherosclerosis and cardiovascular risk. All features of the metabolic syndrome and related events are assessed for practical management of NAFLD, although the criteria for the diagnosis of obesity and central obesity differ across racial groups. CONCLUSIONS: The increasing prevalence of obesity, coupled with diabetes, dyslipidemia, hypertension and ultimately metabolic syndrome, puts a very large population at risk of developing NAFLD in the coming decades. The simultaneous identification and appropriate treatment of the components of metabolic syndrome are crucial to reduce hepatic as well as cardiovascular morbidity and mortality. SN - 1499-3872 UR - https://www.unboundmedicine.com/medline/citation/18086620/Metabolic_syndrome_and_non_alcoholic_fatty_liver_disease:_Asian_definitions_and_Asian_studies_ L2 - http://www.diseaseinfosearch.org/result/4280 DB - PRIME DP - Unbound Medicine ER -