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Combined detection of serum tumor markers for differential diagnosis of solid lesions located at the pancreatic head.
Hepatobiliary Pancreat Dis Int. 2007 Dec; 6(6):641-5.HP

Abstract

BACKGROUND

The differential diagnosis of solid lesions located at the pancreatic head is very important for choosing therapies and setting up surgical tactics. This study was designed to evaluate the clinical significance of combined measurement of multiple serum tumor markers and the application of the receiver-operating characteristic (ROC) curves in the differential diagnosis of solid lesions located at the pancreatic head.

METHODS

The serum levels of CA19-9, CA242, CA50 and carcinoembryonic antigen (CEA) in 112 patients with carcinoma of the pancreatic head and 38 patients with focal chronic pancreatitis in the pancreatic head were measured with ELISA. The sensitivity, specificity, positive likelihood ratio (PLR) and negative likelihood ratio (NLR) of the four serum tumor markers were calculated. The ROC curves for the four serum tumor markers were constructed and the area under the curve (AUC) was calculated.

RESULTS

The AUCs of CA19-9, CA242, CA50 and CEA were 0.805, 0.749, 0.738 and 0.705; the PLRs were 1.91, 3.43, 5.09 and 5.46; and the NLRs were 0.41, 0.56, 0.59 and 0.71, respectively. Combined measurements increased the diagnostic specificity, and parallel combined testing increased the diagnostic sensitivity.

CONCLUSIONS

Combined measurement of serum tumor markers CA19-9, CA242, CA50 and CEA is valuable in differential diagnosis of solid lesions located at the pancreatic head, and CA19-9 has the best diagnostic ability. Combined measurements can increase the specificity of diagnosis. Evaluation with the ROC curve is better than the sensitivity or specificity alone and the results are more integrated and objective.

Authors+Show Affiliations

Department of General Surgery, Peking Union Medical College Hospital, Beijing 100730, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18086633

Citation

Liao, Quan, et al. "Combined Detection of Serum Tumor Markers for Differential Diagnosis of Solid Lesions Located at the Pancreatic Head." Hepatobiliary & Pancreatic Diseases International : HBPD INT, vol. 6, no. 6, 2007, pp. 641-5.
Liao Q, Zhao YP, Yang YC, et al. Combined detection of serum tumor markers for differential diagnosis of solid lesions located at the pancreatic head. HBPD INT. 2007;6(6):641-5.
Liao, Q., Zhao, Y. P., Yang, Y. C., Li, L. J., Long, X., & Han, S. M. (2007). Combined detection of serum tumor markers for differential diagnosis of solid lesions located at the pancreatic head. Hepatobiliary & Pancreatic Diseases International : HBPD INT, 6(6), 641-5.
Liao Q, et al. Combined Detection of Serum Tumor Markers for Differential Diagnosis of Solid Lesions Located at the Pancreatic Head. HBPD INT. 2007;6(6):641-5. PubMed PMID: 18086633.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined detection of serum tumor markers for differential diagnosis of solid lesions located at the pancreatic head. AU - Liao,Quan, AU - Zhao,Yu-Pei, AU - Yang,Ying-Chi, AU - Li,Li-Jun, AU - Long,Xiao, AU - Han,Shao-Mei, PY - 2007/12/19/pubmed PY - 2008/2/22/medline PY - 2007/12/19/entrez SP - 641 EP - 5 JF - Hepatobiliary & pancreatic diseases international : HBPD INT JO - HBPD INT VL - 6 IS - 6 N2 - BACKGROUND: The differential diagnosis of solid lesions located at the pancreatic head is very important for choosing therapies and setting up surgical tactics. This study was designed to evaluate the clinical significance of combined measurement of multiple serum tumor markers and the application of the receiver-operating characteristic (ROC) curves in the differential diagnosis of solid lesions located at the pancreatic head. METHODS: The serum levels of CA19-9, CA242, CA50 and carcinoembryonic antigen (CEA) in 112 patients with carcinoma of the pancreatic head and 38 patients with focal chronic pancreatitis in the pancreatic head were measured with ELISA. The sensitivity, specificity, positive likelihood ratio (PLR) and negative likelihood ratio (NLR) of the four serum tumor markers were calculated. The ROC curves for the four serum tumor markers were constructed and the area under the curve (AUC) was calculated. RESULTS: The AUCs of CA19-9, CA242, CA50 and CEA were 0.805, 0.749, 0.738 and 0.705; the PLRs were 1.91, 3.43, 5.09 and 5.46; and the NLRs were 0.41, 0.56, 0.59 and 0.71, respectively. Combined measurements increased the diagnostic specificity, and parallel combined testing increased the diagnostic sensitivity. CONCLUSIONS: Combined measurement of serum tumor markers CA19-9, CA242, CA50 and CEA is valuable in differential diagnosis of solid lesions located at the pancreatic head, and CA19-9 has the best diagnostic ability. Combined measurements can increase the specificity of diagnosis. Evaluation with the ROC curve is better than the sensitivity or specificity alone and the results are more integrated and objective. SN - 1499-3872 UR - https://www.unboundmedicine.com/medline/citation/18086633/Combined_detection_of_serum_tumor_markers_for_differential_diagnosis_of_solid_lesions_located_at_the_pancreatic_head_ L2 - https://medlineplus.gov/pancreaticcancer.html DB - PRIME DP - Unbound Medicine ER -