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Antileishmanial compounds from Cordia fragrantissima collected in Burma (Myanmar).
J Nat Prod. 2008 Jan; 71(1):18-21.JN

Abstract

A methanol extract of the wood of Cordia fragrantissima, collected in Burma (Myanmar), was found to exhibit significant activity against Leishmania major. Bioassay-guided fractionation of this extract using several chromatographic techniques afforded three new compounds (1-3) and five known compounds (4-8). The structures of the new compounds were revealed on the basis of spectroscopic data interpretation and by X-ray crystallographic analysis. Interestingly, the new compounds, despite the presence of asymmetric carbons, were found to be racemates. The activities of the isolates from C. fragrantissima and several derivatives were evaluated against the promastigote forms of Leishmania major, L. panamensis, and L. guyanensis.

Authors+Show Affiliations

Mori K
Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, Sanuki, Japan.
Kawano M
No affiliation info available
Fuchino H
No affiliation info available
Ooi T
No affiliation info available
Satake M
No affiliation info available
Agatsuma Y
No affiliation info available
Kusumi T
No affiliation info available
Sekita S
No affiliation info available

MeSH

AnimalsAntiprotozoal AgentsCordiaCrystallography, X-RayHydroquinonesLeishmaniaMolecular ConformationMolecular StructureMyanmarParasitic Sensitivity TestsPlants, Medicinal

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18088097

Citation

Mori, Kanami, et al. "Antileishmanial Compounds From Cordia Fragrantissima Collected in Burma (Myanmar)." Journal of Natural Products, vol. 71, no. 1, 2008, pp. 18-21.
Mori K, Kawano M, Fuchino H, et al. Antileishmanial compounds from Cordia fragrantissima collected in Burma (Myanmar). J Nat Prod. 2008;71(1):18-21.
Mori, K., Kawano, M., Fuchino, H., Ooi, T., Satake, M., Agatsuma, Y., Kusumi, T., & Sekita, S. (2008). Antileishmanial compounds from Cordia fragrantissima collected in Burma (Myanmar). Journal of Natural Products, 71(1), 18-21.
Mori K, et al. Antileishmanial Compounds From Cordia Fragrantissima Collected in Burma (Myanmar). J Nat Prod. 2008;71(1):18-21. PubMed PMID: 18088097.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antileishmanial compounds from Cordia fragrantissima collected in Burma (Myanmar). AU - Mori,Kanami, AU - Kawano,Marii, AU - Fuchino,Hiroyuki, AU - Ooi,Takashi, AU - Satake,Motoyoshi, AU - Agatsuma,Yutaka, AU - Kusumi,Takenori, AU - Sekita,Setsuko, Y1 - 2007/12/19/ PY - 2007/12/20/pubmed PY - 2008/4/3/medline PY - 2007/12/20/entrez SP - 18 EP - 21 JF - Journal of natural products JO - J Nat Prod VL - 71 IS - 1 N2 - A methanol extract of the wood of Cordia fragrantissima, collected in Burma (Myanmar), was found to exhibit significant activity against Leishmania major. Bioassay-guided fractionation of this extract using several chromatographic techniques afforded three new compounds (1-3) and five known compounds (4-8). The structures of the new compounds were revealed on the basis of spectroscopic data interpretation and by X-ray crystallographic analysis. Interestingly, the new compounds, despite the presence of asymmetric carbons, were found to be racemates. The activities of the isolates from C. fragrantissima and several derivatives were evaluated against the promastigote forms of Leishmania major, L. panamensis, and L. guyanensis. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/18088097/Antileishmanial_compounds_from_Cordia_fragrantissima_collected_in_Burma__Myanmar__ DB - PRIME DP - Unbound Medicine ER -