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Lifestyle-related factors in predementia and dementia syndromes.

Abstract

Cognitive decline and dementia have a deep impact on the health and quality of life of older subjects and their caregivers. Since the therapeutic options currently available have demonstrated limited efficacy, the search for preventive strategies for cognitive decline and dementia are mandatory. A possible role of lifestyle-related factors was recently proposed for age-related changes of cognitive function, predementia syndromes and the cognitive decline of degenerative (Alzheimer's disease [AD]) or vascular origin. At present, cumulative evidence suggests that vascular risk factors may be important in the development of mild cognitive impairment (MCI), dementia and AD. Moderate alcohol drinking has been proposed as a protective factor against MCI and dementia in several longitudinal studies, but contrasting findings also exist. The Mediterranean diet could therefore be an interesting model with which to further study the association between dietary patterns and cognitive functioning, given the suggested role of many components of this diet (monounsaturated fatty acids, polyunsaturated fatty acids, cereals and red wine) in contrasting cognitive impairment and dementia. The association between low education and predementia and dementia syndromes is supported by the majority of studies, but very few studies have investigated whether this association may be attributed with lifestyle factors that covary with education. Studies in the literature seem to identify in physical exercise one promising strategy in decreasing cognitive decline, but some of the limitations of these studies do not allow us to draw definite conclusions. At present, in older subjects, healthy diets, antioxidant supplements, the prevention of nutritional deficiencies, and moderate physical activity could be considered the first line of defense against the development and progression of predementia and dementia syndromes. However, in most cases, these were only observational studies, and results are awaited from large multicenter randomized clinical trials in older persons that may clarify the possible synergy, for example, between moderate exercise, physical activity and healthy Mediterranean diet on cognition in the elderly.

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  • Authors+Show Affiliations

    ,

    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy. v.solfrizzi@geriatria.uniba.it

    , , , , , , ,

    Source

    Expert review of neurotherapeutics 8:1 2008 Jan pg 133-58

    MeSH

    Alcohol Drinking
    Cognition Disorders
    Dementia
    Diet
    Exercise
    Humans
    Life Style
    Play and Playthings
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    18088206

    Citation

    Solfrizzi, Vincenzo, et al. "Lifestyle-related Factors in Predementia and Dementia Syndromes." Expert Review of Neurotherapeutics, vol. 8, no. 1, 2008, pp. 133-58.
    Solfrizzi V, Capurso C, D'Introno A, et al. Lifestyle-related factors in predementia and dementia syndromes. Expert Rev Neurother. 2008;8(1):133-58.
    Solfrizzi, V., Capurso, C., D'Introno, A., Colacicco, A. M., Santamato, A., Ranieri, M., ... Panza, F. (2008). Lifestyle-related factors in predementia and dementia syndromes. Expert Review of Neurotherapeutics, 8(1), pp. 133-58.
    Solfrizzi V, et al. Lifestyle-related Factors in Predementia and Dementia Syndromes. Expert Rev Neurother. 2008;8(1):133-58. PubMed PMID: 18088206.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Lifestyle-related factors in predementia and dementia syndromes. AU - Solfrizzi,Vincenzo, AU - Capurso,Cristiano, AU - D'Introno,Alessia, AU - Colacicco,Anna Maria, AU - Santamato,Andrea, AU - Ranieri,Maurizio, AU - Fiore,Pietro, AU - Capurso,Antonio, AU - Panza,Francesco, PY - 2007/12/20/pubmed PY - 2008/2/9/medline PY - 2007/12/20/entrez SP - 133 EP - 58 JF - Expert review of neurotherapeutics JO - Expert Rev Neurother VL - 8 IS - 1 N2 - Cognitive decline and dementia have a deep impact on the health and quality of life of older subjects and their caregivers. Since the therapeutic options currently available have demonstrated limited efficacy, the search for preventive strategies for cognitive decline and dementia are mandatory. A possible role of lifestyle-related factors was recently proposed for age-related changes of cognitive function, predementia syndromes and the cognitive decline of degenerative (Alzheimer's disease [AD]) or vascular origin. At present, cumulative evidence suggests that vascular risk factors may be important in the development of mild cognitive impairment (MCI), dementia and AD. Moderate alcohol drinking has been proposed as a protective factor against MCI and dementia in several longitudinal studies, but contrasting findings also exist. The Mediterranean diet could therefore be an interesting model with which to further study the association between dietary patterns and cognitive functioning, given the suggested role of many components of this diet (monounsaturated fatty acids, polyunsaturated fatty acids, cereals and red wine) in contrasting cognitive impairment and dementia. The association between low education and predementia and dementia syndromes is supported by the majority of studies, but very few studies have investigated whether this association may be attributed with lifestyle factors that covary with education. Studies in the literature seem to identify in physical exercise one promising strategy in decreasing cognitive decline, but some of the limitations of these studies do not allow us to draw definite conclusions. At present, in older subjects, healthy diets, antioxidant supplements, the prevention of nutritional deficiencies, and moderate physical activity could be considered the first line of defense against the development and progression of predementia and dementia syndromes. However, in most cases, these were only observational studies, and results are awaited from large multicenter randomized clinical trials in older persons that may clarify the possible synergy, for example, between moderate exercise, physical activity and healthy Mediterranean diet on cognition in the elderly. SN - 1744-8360 UR - https://www.unboundmedicine.com/medline/citation/18088206/Lifestyle_related_factors_in_predementia_and_dementia_syndromes_ L2 - http://www.tandfonline.com/doi/full/10.1586/14737175.8.1.133 DB - PRIME DP - Unbound Medicine ER -