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What will whole genome searches for susceptibility genes for common complex disease offer to clinical practice?
J Intern Med 2008; 263(1):16-27JI

Abstract

In the developed world the majority of disease results from common, but complex disorders such as diabetes, obesity and cancer. Genetic variation explains a large proportion of an individual's risk of developing these diseases; however, success in identifying the particular gene variants involved has been limited. Recent advances in high-throughput genotyping technology, and a better understanding of the genetic architecture of complex disease has led to the development of genome-wide association studies (GWA), which are providing novel and important insights into disease processes. The results from these studies could be of substantial clinical importance in the relatively near future. In this review, we present some recent, exciting findings from studies that have used the GWA approach, and discuss the clinical application of identifying disease susceptibility genes and variants.

Authors+Show Affiliations

Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18088250

Citation

Lango, H, and M N. Weedon. "What Will Whole Genome Searches for Susceptibility Genes for Common Complex Disease Offer to Clinical Practice?" Journal of Internal Medicine, vol. 263, no. 1, 2008, pp. 16-27.
Lango H, Weedon MN. What will whole genome searches for susceptibility genes for common complex disease offer to clinical practice? J Intern Med. 2008;263(1):16-27.
Lango, H., & Weedon, M. N. (2008). What will whole genome searches for susceptibility genes for common complex disease offer to clinical practice? Journal of Internal Medicine, 263(1), pp. 16-27.
Lango H, Weedon MN. What Will Whole Genome Searches for Susceptibility Genes for Common Complex Disease Offer to Clinical Practice. J Intern Med. 2008;263(1):16-27. PubMed PMID: 18088250.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - What will whole genome searches for susceptibility genes for common complex disease offer to clinical practice? AU - Lango,H, AU - Weedon,M N, PY - 2007/12/20/pubmed PY - 2008/1/11/medline PY - 2007/12/20/entrez SP - 16 EP - 27 JF - Journal of internal medicine JO - J. Intern. Med. VL - 263 IS - 1 N2 - In the developed world the majority of disease results from common, but complex disorders such as diabetes, obesity and cancer. Genetic variation explains a large proportion of an individual's risk of developing these diseases; however, success in identifying the particular gene variants involved has been limited. Recent advances in high-throughput genotyping technology, and a better understanding of the genetic architecture of complex disease has led to the development of genome-wide association studies (GWA), which are providing novel and important insights into disease processes. The results from these studies could be of substantial clinical importance in the relatively near future. In this review, we present some recent, exciting findings from studies that have used the GWA approach, and discuss the clinical application of identifying disease susceptibility genes and variants. SN - 1365-2796 UR - https://www.unboundmedicine.com/medline/citation/18088250/What_will_whole_genome_searches_for_susceptibility_genes_for_common_complex_disease_offer_to_clinical_practice L2 - https://doi.org/10.1111/j.1365-2796.2007.01895.x DB - PRIME DP - Unbound Medicine ER -