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Maple syrup urine disease in treated patients: biochemical and oxidative stress profiles.
Clin Biochem. 2008 Mar; 41(4-5):317-24.CB

Abstract

OBJECTIVE

The objective of this study was to evaluate and correlate the biochemical and oxidative stress profiles in MSUD patients during the dietary treatment.

DESIGN AND METHODS

Plasma samples from treated MSUD patients were used to evaluate the biochemical profile and oxidative stress parameters.

RESULTS

It was observed that glucose, total cholesterol, albumin and creatinine are reduced and that aspartate aminotransferase and lactate dehydrogenase activities are increased in plasma from MSUD patients under treatment. Besides, it was verified an increase of thiobarbituric acid-reactive species (TBARS) and a decrease of total antioxidant reactivity (TAR).

CONCLUSIONS

Our results suggest that oxidative stress occurs in treated MSUD patients and that dietary treatment and clinical conditions associated to the disease can lead to biochemical alterations in these patients.

Authors+Show Affiliations

Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, ICBS, UFRGS, Porto Alegre, RS, Brazil. aletheagatto@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18088602

Citation

Barschak, Alethéa G., et al. "Maple Syrup Urine Disease in Treated Patients: Biochemical and Oxidative Stress Profiles." Clinical Biochemistry, vol. 41, no. 4-5, 2008, pp. 317-24.
Barschak AG, Marchesan C, Sitta A, et al. Maple syrup urine disease in treated patients: biochemical and oxidative stress profiles. Clin Biochem. 2008;41(4-5):317-24.
Barschak, A. G., Marchesan, C., Sitta, A., Deon, M., Giugliani, R., Wajner, M., & Vargas, C. R. (2008). Maple syrup urine disease in treated patients: biochemical and oxidative stress profiles. Clinical Biochemistry, 41(4-5), 317-24.
Barschak AG, et al. Maple Syrup Urine Disease in Treated Patients: Biochemical and Oxidative Stress Profiles. Clin Biochem. 2008;41(4-5):317-24. PubMed PMID: 18088602.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maple syrup urine disease in treated patients: biochemical and oxidative stress profiles. AU - Barschak,Alethéa G, AU - Marchesan,Christiane, AU - Sitta,Angela, AU - Deon,Marion, AU - Giugliani,Roberto, AU - Wajner,Moacir, AU - Vargas,Carmen Regla, Y1 - 2007/12/05/ PY - 2007/09/12/received PY - 2007/11/22/revised PY - 2007/11/27/accepted PY - 2007/12/20/pubmed PY - 2008/7/11/medline PY - 2007/12/20/entrez SP - 317 EP - 24 JF - Clinical biochemistry JO - Clin Biochem VL - 41 IS - 4-5 N2 - OBJECTIVE: The objective of this study was to evaluate and correlate the biochemical and oxidative stress profiles in MSUD patients during the dietary treatment. DESIGN AND METHODS: Plasma samples from treated MSUD patients were used to evaluate the biochemical profile and oxidative stress parameters. RESULTS: It was observed that glucose, total cholesterol, albumin and creatinine are reduced and that aspartate aminotransferase and lactate dehydrogenase activities are increased in plasma from MSUD patients under treatment. Besides, it was verified an increase of thiobarbituric acid-reactive species (TBARS) and a decrease of total antioxidant reactivity (TAR). CONCLUSIONS: Our results suggest that oxidative stress occurs in treated MSUD patients and that dietary treatment and clinical conditions associated to the disease can lead to biochemical alterations in these patients. SN - 0009-9120 UR - https://www.unboundmedicine.com/medline/citation/18088602/Maple_syrup_urine_disease_in_treated_patients:_biochemical_and_oxidative_stress_profiles_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-9120(07)00479-1 DB - PRIME DP - Unbound Medicine ER -