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Calcitonin gene-related Peptide-mediated depressor effect and inhibiting vascular hypertrophy of rutaecarpine in renovascular hypertensive rats.
J Cardiovasc Pharmacol. 2007 Dec; 50(6):654-9.JC

Abstract

Calcitonin gene-related peptide (CGRP), the predominant neurotransmitter in capsaicin-sensitive sensory nerves, is a potent vasodilator and inhibits proliferation of vascular smooth muscle cells. Previous investigations have demonstrated that the hypotensive effect of rutaecarpine (Rut) is associated to stimulation of CGRP synthesis and release via activation of the vanilloid receptor subtype 1 (VR1) in the phenol-induced hypertensive rat. This study tested whether the depressor effect and inhibiting vascular hypertrophy of Rut is mediated by endogenous CGRP in 2-kidney, 1-clip (2K1C) hypertensive rats. Systolic blood pressure (SBP) was measured by tail-cuff method in conscious. Mesenteric arteries were isolated for examination of morphological changes. The concentration of CGRP in the plasma and the expression of CGRP mRNA in dorsal root ganglia (DRG) were measured. Chronic administration of Rut (10, 20, or 40 mg/kg/day, respectively) for 4 weeks caused a depressor effect and significantly regressed the lumen diameter and decreased the medium thickness of mesenteric arteries in hypertensive rats concomitantly with an increase in the plasma concentration of CGRP and the expression of CGRP mRNA in DRG. In conclusion, chronic administration of Rut can reduce blood pressure and relieve mesenteric artery hypertrophy in the 2K1C hypertensive rats, and the effects of Rut may be related to stimulation of CGRP synthesis and release.

Authors+Show Affiliations

Department of Pharmacology, University of South China, Hengyang, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18091582

Citation

Qin, Xu-Ping, et al. "Calcitonin Gene-related Peptide-mediated Depressor Effect and Inhibiting Vascular Hypertrophy of Rutaecarpine in Renovascular Hypertensive Rats." Journal of Cardiovascular Pharmacology, vol. 50, no. 6, 2007, pp. 654-9.
Qin XP, Zeng SY, Li D, et al. Calcitonin gene-related Peptide-mediated depressor effect and inhibiting vascular hypertrophy of rutaecarpine in renovascular hypertensive rats. J Cardiovasc Pharmacol. 2007;50(6):654-9.
Qin, X. P., Zeng, S. Y., Li, D., Chen, Q. Q., Luo, D., Zhang, Z., Hu, G. Y., Deng, H. W., & Li, Y. J. (2007). Calcitonin gene-related Peptide-mediated depressor effect and inhibiting vascular hypertrophy of rutaecarpine in renovascular hypertensive rats. Journal of Cardiovascular Pharmacology, 50(6), 654-9.
Qin XP, et al. Calcitonin Gene-related Peptide-mediated Depressor Effect and Inhibiting Vascular Hypertrophy of Rutaecarpine in Renovascular Hypertensive Rats. J Cardiovasc Pharmacol. 2007;50(6):654-9. PubMed PMID: 18091582.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Calcitonin gene-related Peptide-mediated depressor effect and inhibiting vascular hypertrophy of rutaecarpine in renovascular hypertensive rats. AU - Qin,Xu-Ping, AU - Zeng,Si-Yu, AU - Li,Dai, AU - Chen,Qing-Quan, AU - Luo,Dan, AU - Zhang,Zhe, AU - Hu,Gao-Yun, AU - Deng,Han-Wu, AU - Li,Yuan-Jian, PY - 2007/12/20/pubmed PY - 2008/2/28/medline PY - 2007/12/20/entrez SP - 654 EP - 9 JF - Journal of cardiovascular pharmacology JO - J Cardiovasc Pharmacol VL - 50 IS - 6 N2 - Calcitonin gene-related peptide (CGRP), the predominant neurotransmitter in capsaicin-sensitive sensory nerves, is a potent vasodilator and inhibits proliferation of vascular smooth muscle cells. Previous investigations have demonstrated that the hypotensive effect of rutaecarpine (Rut) is associated to stimulation of CGRP synthesis and release via activation of the vanilloid receptor subtype 1 (VR1) in the phenol-induced hypertensive rat. This study tested whether the depressor effect and inhibiting vascular hypertrophy of Rut is mediated by endogenous CGRP in 2-kidney, 1-clip (2K1C) hypertensive rats. Systolic blood pressure (SBP) was measured by tail-cuff method in conscious. Mesenteric arteries were isolated for examination of morphological changes. The concentration of CGRP in the plasma and the expression of CGRP mRNA in dorsal root ganglia (DRG) were measured. Chronic administration of Rut (10, 20, or 40 mg/kg/day, respectively) for 4 weeks caused a depressor effect and significantly regressed the lumen diameter and decreased the medium thickness of mesenteric arteries in hypertensive rats concomitantly with an increase in the plasma concentration of CGRP and the expression of CGRP mRNA in DRG. In conclusion, chronic administration of Rut can reduce blood pressure and relieve mesenteric artery hypertrophy in the 2K1C hypertensive rats, and the effects of Rut may be related to stimulation of CGRP synthesis and release. SN - 0160-2446 UR - https://www.unboundmedicine.com/medline/citation/18091582/Calcitonin_gene_related_Peptide_mediated_depressor_effect_and_inhibiting_vascular_hypertrophy_of_rutaecarpine_in_renovascular_hypertensive_rats_ L2 - https://doi.org/10.1097/FJC.0b013e3181579e7e DB - PRIME DP - Unbound Medicine ER -