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Clinical and capillaroscopic evaluation in the treatment of chronic venous insufficiency with Ruscus aculeatus, hesperidin methylchalcone and ascorbic acid in venous insufficiency treatment of ambulatory patients.
Int Angiol. 2007 Dec; 26(4):378-84.IA

Abstract

AIM

Clinical and capillaroscopic evaluation of an association of Ruscus aculeatus, hesperidin methylchalcone (HMC) and ascorbic acid in chronic venous insufficiency

METHODS

A prospective, multicenter and open clinical study. Chronic venous insufficiency patients were studied using clinical, etiological, anatomical, physiological classification (CEAP) symptom scale. Symptomatology, CEAP scale, and baseline, 2-, 4-, 6- and 8-week skin capillaroscopy were assessed. Treatment consisted of two capsules per day of Ruscus aculeatus 150 mg/HMC 150 mg/ascorbic acid 100 mg during 8 weeks.

RESULTS

A total of 124 patients were studied, 109 female (89.28%), with a mean age of 52.5 (33-80+9.8). Initial intense reports were 79% pain, 85% heaviness, 74% cramps, 82% edema, decreasing to 20%, 12%, 8% and 14%, respectively, within two weeks, and symptomatology being absent at the end of treatment. Capillaroscopy changes at treatment completion were: 98% to 20% inter-capillary fluid decrease; 80% to 20% efferent loop thickening; 5% to 2% peri-capillary bed, and 5% to 4% mega-capillaries.

CONCLUSION

Severe symptom decrease started from the second week until there were no symptoms at the end of treatment. It is the first time morphologic changes were observed in chronic venous insufficiency through capillaroscopy following a pharmacological intervention. Capillary-level effect was proportional to symptom decrease. Improvement was seen from the second week of treatment.

Authors+Show Affiliations

Aguilar Peralta GR
Unit of Angiology and Vascular Surgery - HUMVASCULAR - Guzman City, Jalisco, Mexico. gaguiper@prodigy.net.mx
Arévalo Gardoqui J
No affiliation info available
Llamas Macías FJ
No affiliation info available
Navarro Ceja VH
No affiliation info available
Mendoza Cisneros SA
No affiliation info available
Martínez Macías CG
No affiliation info available

MeSH

AdultAgedAged, 80 and overAntioxidantsAscorbic AcidChalconesChronic DiseaseFemaleHesperidinHumansLegMaleMicroscopic AngioscopyMiddle AgedPhytotherapyPlant ExtractsRuscusVenous Insufficiency

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18091707

Citation

Aguilar Peralta, G R., et al. "Clinical and Capillaroscopic Evaluation in the Treatment of Chronic Venous Insufficiency With Ruscus Aculeatus, Hesperidin Methylchalcone and Ascorbic Acid in Venous Insufficiency Treatment of Ambulatory Patients." International Angiology : a Journal of the International Union of Angiology, vol. 26, no. 4, 2007, pp. 378-84.
Aguilar Peralta GR, Arévalo Gardoqui J, Llamas Macías FJ, et al. Clinical and capillaroscopic evaluation in the treatment of chronic venous insufficiency with Ruscus aculeatus, hesperidin methylchalcone and ascorbic acid in venous insufficiency treatment of ambulatory patients. Int Angiol. 2007;26(4):378-84.
Aguilar Peralta, G. R., Arévalo Gardoqui, J., Llamas Macías, F. J., Navarro Ceja, V. H., Mendoza Cisneros, S. A., & Martínez Macías, C. G. (2007). Clinical and capillaroscopic evaluation in the treatment of chronic venous insufficiency with Ruscus aculeatus, hesperidin methylchalcone and ascorbic acid in venous insufficiency treatment of ambulatory patients. International Angiology : a Journal of the International Union of Angiology, 26(4), 378-84.
Aguilar Peralta GR, et al. Clinical and Capillaroscopic Evaluation in the Treatment of Chronic Venous Insufficiency With Ruscus Aculeatus, Hesperidin Methylchalcone and Ascorbic Acid in Venous Insufficiency Treatment of Ambulatory Patients. Int Angiol. 2007;26(4):378-84. PubMed PMID: 18091707.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical and capillaroscopic evaluation in the treatment of chronic venous insufficiency with Ruscus aculeatus, hesperidin methylchalcone and ascorbic acid in venous insufficiency treatment of ambulatory patients. AU - Aguilar Peralta,G R, AU - Arévalo Gardoqui,J, AU - Llamas Macías,F J, AU - Navarro Ceja,V H, AU - Mendoza Cisneros,S A, AU - Martínez Macías,C G, PY - 2007/12/20/pubmed PY - 2008/5/8/medline PY - 2007/12/20/entrez SP - 378 EP - 84 JF - International angiology : a journal of the International Union of Angiology JO - Int Angiol VL - 26 IS - 4 N2 - AIM: Clinical and capillaroscopic evaluation of an association of Ruscus aculeatus, hesperidin methylchalcone (HMC) and ascorbic acid in chronic venous insufficiency METHODS: A prospective, multicenter and open clinical study. Chronic venous insufficiency patients were studied using clinical, etiological, anatomical, physiological classification (CEAP) symptom scale. Symptomatology, CEAP scale, and baseline, 2-, 4-, 6- and 8-week skin capillaroscopy were assessed. Treatment consisted of two capsules per day of Ruscus aculeatus 150 mg/HMC 150 mg/ascorbic acid 100 mg during 8 weeks. RESULTS: A total of 124 patients were studied, 109 female (89.28%), with a mean age of 52.5 (33-80+9.8). Initial intense reports were 79% pain, 85% heaviness, 74% cramps, 82% edema, decreasing to 20%, 12%, 8% and 14%, respectively, within two weeks, and symptomatology being absent at the end of treatment. Capillaroscopy changes at treatment completion were: 98% to 20% inter-capillary fluid decrease; 80% to 20% efferent loop thickening; 5% to 2% peri-capillary bed, and 5% to 4% mega-capillaries. CONCLUSION: Severe symptom decrease started from the second week until there were no symptoms at the end of treatment. It is the first time morphologic changes were observed in chronic venous insufficiency through capillaroscopy following a pharmacological intervention. Capillary-level effect was proportional to symptom decrease. Improvement was seen from the second week of treatment. SN - 0392-9590 UR - https://www.unboundmedicine.com/medline/citation/18091707/Clinical_and_capillaroscopic_evaluation_in_the_treatment_of_chronic_venous_insufficiency_with_Ruscus_aculeatus_hesperidin_methylchalcone_and_ascorbic_acid_in_venous_insufficiency_treatment_of_ambulatory_patients_ DB - PRIME DP - Unbound Medicine ER -