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Research Review: genetic vulnerability or differential susceptibility in child development: the case of attachment.
J Child Psychol Psychiatry. 2007 Dec; 48(12):1160-73.JC

Abstract

Gene-environment interactions interpreted in terms of differential susceptibility may play a large part in the explanation of individual differences in human development. Reviewing studies on the behavioral and molecular genetics of attachment, we present evidence for interactions between genetic and environmental factors explaining individual differences in attachment security and disorganization. In particular, the DRD4 7-repeat polymorphism seems associated with an increased risk for disorganized attachment, but only when combined with environmental risk. Gene-environment (G x E) interactions may be interpreted as genetic vulnerability or differential susceptibility. We found support for the differential susceptibility hypothesis predicting not only more negative outcomes for susceptible children in unfavorable environments, but also positive outcomes for susceptible children in favorable environments.

Authors+Show Affiliations

Centre for Child and Family Studies, Leiden University, Leiden, The Netherlands. bakermans@fsw.leidennuniv.nlNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18093021

Citation

Bakermans-Kranenburg, Marian J., and Marinus H. van Ijzendoorn. "Research Review: Genetic Vulnerability or Differential Susceptibility in Child Development: the Case of Attachment." Journal of Child Psychology and Psychiatry, and Allied Disciplines, vol. 48, no. 12, 2007, pp. 1160-73.
Bakermans-Kranenburg MJ, van Ijzendoorn MH. Research Review: genetic vulnerability or differential susceptibility in child development: the case of attachment. J Child Psychol Psychiatry. 2007;48(12):1160-73.
Bakermans-Kranenburg, M. J., & van Ijzendoorn, M. H. (2007). Research Review: genetic vulnerability or differential susceptibility in child development: the case of attachment. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 48(12), 1160-73.
Bakermans-Kranenburg MJ, van Ijzendoorn MH. Research Review: Genetic Vulnerability or Differential Susceptibility in Child Development: the Case of Attachment. J Child Psychol Psychiatry. 2007;48(12):1160-73. PubMed PMID: 18093021.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Research Review: genetic vulnerability or differential susceptibility in child development: the case of attachment. AU - Bakermans-Kranenburg,Marian J, AU - van Ijzendoorn,Marinus H, PY - 2007/12/21/pubmed PY - 2008/2/8/medline PY - 2007/12/21/entrez SP - 1160 EP - 73 JF - Journal of child psychology and psychiatry, and allied disciplines JO - J Child Psychol Psychiatry VL - 48 IS - 12 N2 - Gene-environment interactions interpreted in terms of differential susceptibility may play a large part in the explanation of individual differences in human development. Reviewing studies on the behavioral and molecular genetics of attachment, we present evidence for interactions between genetic and environmental factors explaining individual differences in attachment security and disorganization. In particular, the DRD4 7-repeat polymorphism seems associated with an increased risk for disorganized attachment, but only when combined with environmental risk. Gene-environment (G x E) interactions may be interpreted as genetic vulnerability or differential susceptibility. We found support for the differential susceptibility hypothesis predicting not only more negative outcomes for susceptible children in unfavorable environments, but also positive outcomes for susceptible children in favorable environments. SN - 0021-9630 UR - https://www.unboundmedicine.com/medline/citation/18093021/Research_Review:_genetic_vulnerability_or_differential_susceptibility_in_child_development:_the_case_of_attachment_ L2 - https://doi.org/10.1111/j.1469-7610.2007.01801.x DB - PRIME DP - Unbound Medicine ER -