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Renoprotective action of L-carnitine in fructose-induced metabolic syndrome.
Diabetes Obes Metab. 2008 Feb; 10(2):171-80.DO

Abstract

AIM

Rats fed high dosage of fructose that form a well-known experimental model of the metabolic syndrome also display progressive renal disturbances. The present study evaluates the influence of l-carnitine (CA) administration on oxidant-antioxidant balance, protein damage and lipid levels in kidney of rats administered high dose of fructose.

METHODS

Adult male Wistar rats were divided into four groups of 10 rats each. Groups I and IV animals received starch-based control diet, while groups II and III rats were fed a high-fructose diet (60 g/100 g). Groups III and IV animals additionally received CA (300 mg/kg/day) for 60 days. The extent of lipid peroxidation, enzymatic and non-enzymatic antioxidants and lipid levels were measured after 60 days. The accumulation of nitrated and oxidatively modified proteins in kidney was also measured by immunohistochemical study with specific antibodies.

RESULTS

Fructose-fed rats exhibited increased levels of peroxidation end products, diminished antioxidant status, increased staining for the presence of 4-hydroxy-2-nonenal, 2,4-dinitrophenol and 3-nitrotyrosine protein adducts and lipid accumulation in kidney. CA administration attenuated these pathological renal alterations.

CONCLUSIONS

The benefits of CA in this model suggest the therapeutic use of CA to counter the kidney changes associated with metabolic syndrome.

Authors+Show Affiliations

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Tamil Nadu, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18093214

Citation

Rajasekar, P, et al. "Renoprotective Action of L-carnitine in Fructose-induced Metabolic Syndrome." Diabetes, Obesity & Metabolism, vol. 10, no. 2, 2008, pp. 171-80.
Rajasekar P, Viswanathan P, Anuradha CV. Renoprotective action of L-carnitine in fructose-induced metabolic syndrome. Diabetes Obes Metab. 2008;10(2):171-80.
Rajasekar, P., Viswanathan, P., & Anuradha, C. V. (2008). Renoprotective action of L-carnitine in fructose-induced metabolic syndrome. Diabetes, Obesity & Metabolism, 10(2), 171-80.
Rajasekar P, Viswanathan P, Anuradha CV. Renoprotective Action of L-carnitine in Fructose-induced Metabolic Syndrome. Diabetes Obes Metab. 2008;10(2):171-80. PubMed PMID: 18093214.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Renoprotective action of L-carnitine in fructose-induced metabolic syndrome. AU - Rajasekar,P, AU - Viswanathan,P, AU - Anuradha,C V, Y1 - 2007/12/17/ PY - 2007/12/21/pubmed PY - 2008/6/3/medline PY - 2007/12/21/entrez SP - 171 EP - 80 JF - Diabetes, obesity & metabolism JO - Diabetes Obes Metab VL - 10 IS - 2 N2 - AIM: Rats fed high dosage of fructose that form a well-known experimental model of the metabolic syndrome also display progressive renal disturbances. The present study evaluates the influence of l-carnitine (CA) administration on oxidant-antioxidant balance, protein damage and lipid levels in kidney of rats administered high dose of fructose. METHODS: Adult male Wistar rats were divided into four groups of 10 rats each. Groups I and IV animals received starch-based control diet, while groups II and III rats were fed a high-fructose diet (60 g/100 g). Groups III and IV animals additionally received CA (300 mg/kg/day) for 60 days. The extent of lipid peroxidation, enzymatic and non-enzymatic antioxidants and lipid levels were measured after 60 days. The accumulation of nitrated and oxidatively modified proteins in kidney was also measured by immunohistochemical study with specific antibodies. RESULTS: Fructose-fed rats exhibited increased levels of peroxidation end products, diminished antioxidant status, increased staining for the presence of 4-hydroxy-2-nonenal, 2,4-dinitrophenol and 3-nitrotyrosine protein adducts and lipid accumulation in kidney. CA administration attenuated these pathological renal alterations. CONCLUSIONS: The benefits of CA in this model suggest the therapeutic use of CA to counter the kidney changes associated with metabolic syndrome. SN - 1463-1326 UR - https://www.unboundmedicine.com/medline/citation/18093214/Renoprotective_action_of_L_carnitine_in_fructose_induced_metabolic_syndrome_ L2 - https://doi.org/10.1111/j.1463-1326.2007.00825.x DB - PRIME DP - Unbound Medicine ER -