TY - JOUR T1 - Renoprotective action of L-carnitine in fructose-induced metabolic syndrome. AU - Rajasekar,P, AU - Viswanathan,P, AU - Anuradha,C V, Y1 - 2007/12/17/ PY - 2007/12/21/pubmed PY - 2008/6/3/medline PY - 2007/12/21/entrez SP - 171 EP - 80 JF - Diabetes, obesity & metabolism JO - Diabetes Obes Metab VL - 10 IS - 2 N2 - AIM: Rats fed high dosage of fructose that form a well-known experimental model of the metabolic syndrome also display progressive renal disturbances. The present study evaluates the influence of l-carnitine (CA) administration on oxidant-antioxidant balance, protein damage and lipid levels in kidney of rats administered high dose of fructose. METHODS: Adult male Wistar rats were divided into four groups of 10 rats each. Groups I and IV animals received starch-based control diet, while groups II and III rats were fed a high-fructose diet (60 g/100 g). Groups III and IV animals additionally received CA (300 mg/kg/day) for 60 days. The extent of lipid peroxidation, enzymatic and non-enzymatic antioxidants and lipid levels were measured after 60 days. The accumulation of nitrated and oxidatively modified proteins in kidney was also measured by immunohistochemical study with specific antibodies. RESULTS: Fructose-fed rats exhibited increased levels of peroxidation end products, diminished antioxidant status, increased staining for the presence of 4-hydroxy-2-nonenal, 2,4-dinitrophenol and 3-nitrotyrosine protein adducts and lipid accumulation in kidney. CA administration attenuated these pathological renal alterations. CONCLUSIONS: The benefits of CA in this model suggest the therapeutic use of CA to counter the kidney changes associated with metabolic syndrome. SN - 1463-1326 UR - https://www.unboundmedicine.com/medline/citation/18093214/Renoprotective_action_of_L_carnitine_in_fructose_induced_metabolic_syndrome_ L2 - https://doi.org/10.1111/j.1463-1326.2007.00825.x DB - PRIME DP - Unbound Medicine ER -