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Physical activity and dementia risk in the elderly: findings from a prospective Italian study.
Neurology 2008; 70(19 Pt 2):1786-94Neur

Abstract

OBJECTIVE

To examine the effect of physical activity on risk of developing Alzheimer disease (AD) and vascular dementia (VaD) in the elderly.

METHODS

Data are from a prospective population-based cohort of 749 Italian subjects aged 65 and older who, in 1999/2000, were cognitively normal at an extensive assessment for clinically overt and preclinical dementia and, in 2003/2004, underwent follow-up for incident dementia. Baseline physical activity was measured as energy expenditure on activities of different intensity (walking, stair climbing, moderate activities, vigorous activities, and total physical activity).

RESULTS

Over 3.9 +/- 0.7 years of follow-up there were 86 incident dementia cases (54 AD, 27 VaD). After adjustment for sociodemographic and genetic confounders, VaD risk was significantly lower for the upper tertiles of walking (hazard ratio [HR] 0.27, 95% CI 0.12 to 0.63), moderate (HR 0.29, 95% CI 0.12 to 0.66), and total physical activity (HR 0.24, 95% 0.11 to 0.56) compared to the corresponding lowest tertile. The association persisted after accounting for vascular risk factors and overall health status. After adjustment for sociodemographic and genetic confounders, AD risk was not associated with measures of physical activity and results did not change after further adjustment for vascular risk factors and overall health and functional status.

CONCLUSIONS

In this cohort, physical activity is associated with a lower risk of vascular dementia but not of Alzheimer disease. Further research is needed about the biologic mechanisms operating between physical activity and cognition.

Authors+Show Affiliations

Department of Internal Medicine, University Hospital S. Orsola-Malpighi, Via Massarenti, 9-40138 Bologna, Italy. giovanni.ravaglia@unibo.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18094335

Citation

Ravaglia, G, et al. "Physical Activity and Dementia Risk in the Elderly: Findings From a Prospective Italian Study." Neurology, vol. 70, no. 19 Pt 2, 2008, pp. 1786-94.
Ravaglia G, Forti P, Lucicesare A, et al. Physical activity and dementia risk in the elderly: findings from a prospective Italian study. Neurology. 2008;70(19 Pt 2):1786-94.
Ravaglia, G., Forti, P., Lucicesare, A., Pisacane, N., Rietti, E., Bianchin, M., & Dalmonte, E. (2008). Physical activity and dementia risk in the elderly: findings from a prospective Italian study. Neurology, 70(19 Pt 2), pp. 1786-94.
Ravaglia G, et al. Physical Activity and Dementia Risk in the Elderly: Findings From a Prospective Italian Study. Neurology. 2008 May 6;70(19 Pt 2):1786-94. PubMed PMID: 18094335.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physical activity and dementia risk in the elderly: findings from a prospective Italian study. AU - Ravaglia,G, AU - Forti,P, AU - Lucicesare,A, AU - Pisacane,N, AU - Rietti,E, AU - Bianchin,M, AU - Dalmonte,E, Y1 - 2007/12/19/ PY - 2007/12/21/pubmed PY - 2008/6/7/medline PY - 2007/12/21/entrez SP - 1786 EP - 94 JF - Neurology JO - Neurology VL - 70 IS - 19 Pt 2 N2 - OBJECTIVE: To examine the effect of physical activity on risk of developing Alzheimer disease (AD) and vascular dementia (VaD) in the elderly. METHODS: Data are from a prospective population-based cohort of 749 Italian subjects aged 65 and older who, in 1999/2000, were cognitively normal at an extensive assessment for clinically overt and preclinical dementia and, in 2003/2004, underwent follow-up for incident dementia. Baseline physical activity was measured as energy expenditure on activities of different intensity (walking, stair climbing, moderate activities, vigorous activities, and total physical activity). RESULTS: Over 3.9 +/- 0.7 years of follow-up there were 86 incident dementia cases (54 AD, 27 VaD). After adjustment for sociodemographic and genetic confounders, VaD risk was significantly lower for the upper tertiles of walking (hazard ratio [HR] 0.27, 95% CI 0.12 to 0.63), moderate (HR 0.29, 95% CI 0.12 to 0.66), and total physical activity (HR 0.24, 95% 0.11 to 0.56) compared to the corresponding lowest tertile. The association persisted after accounting for vascular risk factors and overall health status. After adjustment for sociodemographic and genetic confounders, AD risk was not associated with measures of physical activity and results did not change after further adjustment for vascular risk factors and overall health and functional status. CONCLUSIONS: In this cohort, physical activity is associated with a lower risk of vascular dementia but not of Alzheimer disease. Further research is needed about the biologic mechanisms operating between physical activity and cognition. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/18094335/Physical_activity_and_dementia_risk_in_the_elderly:_findings_from_a_prospective_Italian_study_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=18094335 DB - PRIME DP - Unbound Medicine ER -