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Particle sizes of colloids to be used in sentinel lymph node radiolocalization.
Nucl Med Commun. 2008 Feb; 29(2):166-72.NM

Abstract

OBJECTIVES

To investigate particle size distribution and possible effects of colloid concentration and time after its preparation on the particle sizes of albumin nanocolloid (Nanocoll), rhenium sulfide nanocolloid (Nanocis) and tin colloid (Hepatate).

METHODS

All three kits were prepared according to the manufacturers' instructions using the following volumes of decayed Tc generator eluate: 1.5 ml, 3.5 ml and 5.0 ml (albumin nanocolloid); 1.0 ml, 2.0 ml and 3.0 ml (rhenium sulfide nanocolloid); 3.0 ml, 5.0 ml and 9.0 ml (tin colloid). The particle sizes were determined by photon correlation spectroscopy inmediately after preparation, then at 30 min, 1 h, 2 h, 3 h and 4 h (all three kits) and at 6 h (Nanocoll and Hepatate). Each measurement was performed in three different preparations.

RESULTS

The particle sizes of the three colloids did not change significantly after preparation throughout their period of validity. For Nanocoll, 95% of the particles were between 3 and 16 nm, approximately (mean around 8 nm). Small (< or =1 nm) but significant variations on the mean diameter were found depending on the volume of pertechnetate used in the preparation. For Nanocis, 95% of the particles were between 8 and 68 nm, approximately (mean around 23-25 nm). In this kit, there were no significant differences among colloidal suspensions prepared with different volumes of pertechnetate. For Hepatate, 95% of the particles were between 33 and 255 nm, approximately (mean, around 72-90 nm). The upper limit and the mean size increase with the volume of eluate used were from 190 nm and 73 nm (3 ml) to 255 nm and 85 nm (9 ml).

CONCLUSIONS

The particle sizes of Nanocoll, Nanocis and Hepatate are very stable throughout their period of validity. For Nanocoll, 95% of particles have a diameter <16 nm, with a mean diameter around 8 nm. There are small (< or =1 nm) but significant variations on the mean diameter depending on the volume of pertechnetate used in its preparation. For Nanocis, 95% of particles have a diameter <70 nm, with a mean around 24 nm, and are independent of the volume of pertechnetate used in their preparation. For Hepatate, the upper size limit for 95% of particles is between 190 and 255 nm, with a mean between 72 and 88 nm, depending on the volume of pertechnetate used in its preparation. This tin colloid could be a good candidate for evaluating clinical suitability in sentinel node localization.

Authors+Show Affiliations

Radiopharmacy Unit, Hospital Universitari de Bellvitge-IDIBELL, Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18094639

Citation

Jimenez, Ignacio R., et al. "Particle Sizes of Colloids to Be Used in Sentinel Lymph Node Radiolocalization." Nuclear Medicine Communications, vol. 29, no. 2, 2008, pp. 166-72.
Jimenez IR, Roca M, Vega E, et al. Particle sizes of colloids to be used in sentinel lymph node radiolocalization. Nucl Med Commun. 2008;29(2):166-72.
Jimenez, I. R., Roca, M., Vega, E., García, M. L., Benitez, A., Bajén, M., & Martín-Comín, J. (2008). Particle sizes of colloids to be used in sentinel lymph node radiolocalization. Nuclear Medicine Communications, 29(2), 166-72.
Jimenez IR, et al. Particle Sizes of Colloids to Be Used in Sentinel Lymph Node Radiolocalization. Nucl Med Commun. 2008;29(2):166-72. PubMed PMID: 18094639.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Particle sizes of colloids to be used in sentinel lymph node radiolocalization. AU - Jimenez,Ignacio R, AU - Roca,Manuel, AU - Vega,Estefania, AU - García,Ma Luisa, AU - Benitez,Ana, AU - Bajén,Maite, AU - Martín-Comín,Josep, PY - 2007/12/21/pubmed PY - 2008/4/1/medline PY - 2007/12/21/entrez SP - 166 EP - 72 JF - Nuclear medicine communications JO - Nucl Med Commun VL - 29 IS - 2 N2 - OBJECTIVES: To investigate particle size distribution and possible effects of colloid concentration and time after its preparation on the particle sizes of albumin nanocolloid (Nanocoll), rhenium sulfide nanocolloid (Nanocis) and tin colloid (Hepatate). METHODS: All three kits were prepared according to the manufacturers' instructions using the following volumes of decayed Tc generator eluate: 1.5 ml, 3.5 ml and 5.0 ml (albumin nanocolloid); 1.0 ml, 2.0 ml and 3.0 ml (rhenium sulfide nanocolloid); 3.0 ml, 5.0 ml and 9.0 ml (tin colloid). The particle sizes were determined by photon correlation spectroscopy inmediately after preparation, then at 30 min, 1 h, 2 h, 3 h and 4 h (all three kits) and at 6 h (Nanocoll and Hepatate). Each measurement was performed in three different preparations. RESULTS: The particle sizes of the three colloids did not change significantly after preparation throughout their period of validity. For Nanocoll, 95% of the particles were between 3 and 16 nm, approximately (mean around 8 nm). Small (< or =1 nm) but significant variations on the mean diameter were found depending on the volume of pertechnetate used in the preparation. For Nanocis, 95% of the particles were between 8 and 68 nm, approximately (mean around 23-25 nm). In this kit, there were no significant differences among colloidal suspensions prepared with different volumes of pertechnetate. For Hepatate, 95% of the particles were between 33 and 255 nm, approximately (mean, around 72-90 nm). The upper limit and the mean size increase with the volume of eluate used were from 190 nm and 73 nm (3 ml) to 255 nm and 85 nm (9 ml). CONCLUSIONS: The particle sizes of Nanocoll, Nanocis and Hepatate are very stable throughout their period of validity. For Nanocoll, 95% of particles have a diameter <16 nm, with a mean diameter around 8 nm. There are small (< or =1 nm) but significant variations on the mean diameter depending on the volume of pertechnetate used in its preparation. For Nanocis, 95% of particles have a diameter <70 nm, with a mean around 24 nm, and are independent of the volume of pertechnetate used in their preparation. For Hepatate, the upper size limit for 95% of particles is between 190 and 255 nm, with a mean between 72 and 88 nm, depending on the volume of pertechnetate used in its preparation. This tin colloid could be a good candidate for evaluating clinical suitability in sentinel node localization. SN - 0143-3636 UR - https://www.unboundmedicine.com/medline/citation/18094639/Particle_sizes_of_colloids_to_be_used_in_sentinel_lymph_node_radiolocalization_ DB - PRIME DP - Unbound Medicine ER -