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[Vitamin E: protection of membrane polyunsaturated fatty acids against radical peroxidation in the course of cerebral aging, particularly in cerebral capillaries and microvessels].
Bull Acad Natl Med 1991; 175(8):1305-17; discussion 1317-21BA

Abstract

Nerve tissue (as well as capillaries and cerebral microvessels) has a very high concentration in polyunsaturated fatty acids belonging to linoleic and alpha-linolenic series. Nerve tissue also requires large amounts of oxygen. Radical peroxidation of the polyunsaturated fatty acids represents a serious risk to the biochemistry and physiology of the membranes: it can be a cause of cellular death. During aging, the capillaries and cerebral microvessels undergo extensive modifications at the level of the polyunsaturated fatty acids: for example, the concentration of arachidonic acid decreases by half. In brain in general, vitamin E is very well protected: after oxidation, it is rapidly regenerated; it seems to undergo only slight degradation. In case of dietary deficiency, the brain loses much less vitamin E, and at a slower rate, than other non-nerve tissue. During aging, there is a relation between the content in vitamin E and the concentration of polyunsaturated fatty acids of the linoleic series, but not of the alpha-linolenic series. In addition, vitamin E deficiency also leads to a decrease in the enzymatic activities that protect against peroxidation of fatty acids.

Authors+Show Affiliations

INSERM U. 26, Hôpital Fernand Widal, Paris, France.

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

1809500

Citation

Bourre, J M.. "[Vitamin E: Protection of Membrane Polyunsaturated Fatty Acids Against Radical Peroxidation in the Course of Cerebral Aging, Particularly in Cerebral Capillaries and Microvessels]." Bulletin De l'Academie Nationale De Medecine, vol. 175, no. 8, 1991, pp. 1305-17; discussion 1317-21.
Bourre JM. [Vitamin E: protection of membrane polyunsaturated fatty acids against radical peroxidation in the course of cerebral aging, particularly in cerebral capillaries and microvessels]. Bull Acad Natl Med. 1991;175(8):1305-17; discussion 1317-21.
Bourre, J. M. (1991). [Vitamin E: protection of membrane polyunsaturated fatty acids against radical peroxidation in the course of cerebral aging, particularly in cerebral capillaries and microvessels]. Bulletin De l'Academie Nationale De Medecine, 175(8), pp. 1305-17; discussion 1317-21.
Bourre JM. [Vitamin E: Protection of Membrane Polyunsaturated Fatty Acids Against Radical Peroxidation in the Course of Cerebral Aging, Particularly in Cerebral Capillaries and Microvessels]. Bull Acad Natl Med. 1991;175(8):1305-17; discussion 1317-21. PubMed PMID: 1809500.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Vitamin E: protection of membrane polyunsaturated fatty acids against radical peroxidation in the course of cerebral aging, particularly in cerebral capillaries and microvessels]. A1 - Bourre,J M, PY - 1991/11/1/pubmed PY - 1991/11/1/medline PY - 1991/11/1/entrez SP - 1305-17; discussion 1317-21 JF - Bulletin de l'Academie nationale de medecine JO - Bull. Acad. Natl. Med. VL - 175 IS - 8 N2 - Nerve tissue (as well as capillaries and cerebral microvessels) has a very high concentration in polyunsaturated fatty acids belonging to linoleic and alpha-linolenic series. Nerve tissue also requires large amounts of oxygen. Radical peroxidation of the polyunsaturated fatty acids represents a serious risk to the biochemistry and physiology of the membranes: it can be a cause of cellular death. During aging, the capillaries and cerebral microvessels undergo extensive modifications at the level of the polyunsaturated fatty acids: for example, the concentration of arachidonic acid decreases by half. In brain in general, vitamin E is very well protected: after oxidation, it is rapidly regenerated; it seems to undergo only slight degradation. In case of dietary deficiency, the brain loses much less vitamin E, and at a slower rate, than other non-nerve tissue. During aging, there is a relation between the content in vitamin E and the concentration of polyunsaturated fatty acids of the linoleic series, but not of the alpha-linolenic series. In addition, vitamin E deficiency also leads to a decrease in the enzymatic activities that protect against peroxidation of fatty acids. SN - 0001-4079 UR - https://www.unboundmedicine.com/medline/citation/1809500/[Vitamin_E:_protection_of_membrane_polyunsaturated_fatty_acids_against_radical_peroxidation_in_the_course_of_cerebral_aging_particularly_in_cerebral_capillaries_and_microvessels]_ L2 - https://medlineplus.gov/vitamine.html DB - PRIME DP - Unbound Medicine ER -