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[Correlation between measles-neutralizing antibody and HI antibody, between measles-neutralizing antibody and PA antibody among pregnant women, and protective levels of three titration types].
Kansenshogaku Zasshi. 2007 Nov; 81(6):675-80.KZ

Abstract

When measles antibody levels among pregnant women were measured with measles hemagglutinin inhibition (HI), 31% of subjects had negative HI antibody titers. When the same blood samples were tested with measles gelatin particle agglutination (PA) and neutralizing (NT), the percentages of those with negative antibody levels were 1% and 3%. We conducted the correlation between antibody titers measured by the three types of titration. Correlation between NT and HI antibody titers higher than 1:8 and that between NT and PA antibody titers were good, but 81% of subjects whose HI antibody titer was below 1:8 and all women with HI antibody of 1:8 were found to have NT antibody titer higher than 1:4. NT antibody titer higher than 1:4 was found in 95% of women having PA antibody titer of 1:256 and in 99% of those with PA antibody titer of 1:512. Based on the relationships to measles NT antibody level, the majority of subjects with HI antibody titer higher than 1:8 or PA antibody level higher than 1:512 was reasonably assumed to be protected against clinical measles. PA seemed superior to HI in finding subjects with insufficient immunity against measles, because the former detects weak immunity more efficiently than the latter.

Authors+Show Affiliations

Takayama N
Department of Pediatrics, Tokyo Metropolitan Komagome Hospital.
Shoda A
No affiliation info available
Okazaki T
No affiliation info available
Ichinohe S
No affiliation info available
Saika S
No affiliation info available
Inaba N
No affiliation info available

MeSH

Antibodies, ViralFemaleHemagglutination Inhibition TestsHumansMeasles virusNeutralization TestsPregnancy

Pub Type(s)

Comparative Study
English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

jpn

PubMed ID

18095465

Citation

Takayama, Naohide, et al. "[Correlation Between Measles-neutralizing Antibody and HI Antibody, Between Measles-neutralizing Antibody and PA Antibody Among Pregnant Women, and Protective Levels of Three Titration Types]." Kansenshogaku Zasshi. the Journal of the Japanese Association for Infectious Diseases, vol. 81, no. 6, 2007, pp. 675-80.
Takayama N, Shoda A, Okazaki T, et al. [Correlation between measles-neutralizing antibody and HI antibody, between measles-neutralizing antibody and PA antibody among pregnant women, and protective levels of three titration types]. Kansenshogaku Zasshi. 2007;81(6):675-80.
Takayama, N., Shoda, A., Okazaki, T., Ichinohe, S., Saika, S., & Inaba, N. (2007). [Correlation between measles-neutralizing antibody and HI antibody, between measles-neutralizing antibody and PA antibody among pregnant women, and protective levels of three titration types]. Kansenshogaku Zasshi. the Journal of the Japanese Association for Infectious Diseases, 81(6), 675-80.
Takayama N, et al. [Correlation Between Measles-neutralizing Antibody and HI Antibody, Between Measles-neutralizing Antibody and PA Antibody Among Pregnant Women, and Protective Levels of Three Titration Types]. Kansenshogaku Zasshi. 2007;81(6):675-80. PubMed PMID: 18095465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Correlation between measles-neutralizing antibody and HI antibody, between measles-neutralizing antibody and PA antibody among pregnant women, and protective levels of three titration types]. AU - Takayama,Naohide, AU - Shoda,Akiko, AU - Okazaki,Takayuki, AU - Ichinohe,Sadato, AU - Saika,Shizuko, AU - Inaba,Noriyuki, PY - 2007/12/22/pubmed PY - 2008/2/28/medline PY - 2007/12/22/entrez SP - 675 EP - 80 JF - Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases JO - Kansenshogaku Zasshi VL - 81 IS - 6 N2 - When measles antibody levels among pregnant women were measured with measles hemagglutinin inhibition (HI), 31% of subjects had negative HI antibody titers. When the same blood samples were tested with measles gelatin particle agglutination (PA) and neutralizing (NT), the percentages of those with negative antibody levels were 1% and 3%. We conducted the correlation between antibody titers measured by the three types of titration. Correlation between NT and HI antibody titers higher than 1:8 and that between NT and PA antibody titers were good, but 81% of subjects whose HI antibody titer was below 1:8 and all women with HI antibody of 1:8 were found to have NT antibody titer higher than 1:4. NT antibody titer higher than 1:4 was found in 95% of women having PA antibody titer of 1:256 and in 99% of those with PA antibody titer of 1:512. Based on the relationships to measles NT antibody level, the majority of subjects with HI antibody titer higher than 1:8 or PA antibody level higher than 1:512 was reasonably assumed to be protected against clinical measles. PA seemed superior to HI in finding subjects with insufficient immunity against measles, because the former detects weak immunity more efficiently than the latter. SN - 0387-5911 UR - https://www.unboundmedicine.com/medline/citation/18095465/[Correlation_between_measles_neutralizing_antibody_and_HI_antibody_between_measles_neutralizing_antibody_and_PA_antibody_among_pregnant_women_and_protective_levels_of_three_titration_types]_ DB - PRIME DP - Unbound Medicine ER -