Tags

Type your tag names separated by a space and hit enter

Cytotoxic triterpenoid saponins acylated with monoterpenic acid from Pithecellobium lucidum.
J Nat Prod. 2008 Jan; 71(1):41-6.JN

Abstract

Three new oleanane-type triterpene saponins, named pithelucosides A-C (1-3), together with two known saponins (4, 5) were isolated from the roots of Pithecellobium lucidum. The structures of the new saponins were established on the basis of extensive 1D and 2D NMR experiments and mass spectrometry and confirmed by acid and alkaline hydrolysis. Compounds 1-5 and 7 (pro-sapogenin obtained from the mild alkaline hydrolysate of 1) were evaluated for cytotoxic activity on five human tumoral cell lines (HCT-8, Bel-7402, BGC-823, A549, and A2780) and for hemolytic property against rabbit erythrocytes. Compounds 2-5 showed significant cytotoxic activities with IC50 values of 0.61-7.56 microM. All tested compounds did not exhibit any hemolytic activity in the concentration range 0.01-100 microM.

Authors+Show Affiliations

Ma SG
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education & Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Hu YC
No affiliation info available
Yu SS
No affiliation info available
Zhang Y
No affiliation info available
Chen XG
No affiliation info available
Liu J
No affiliation info available
Liu YX
No affiliation info available

MeSH

AnimalsAntineoplastic Agents, PhytogenicDrug Screening Assays, AntitumorErythrocytesFabaceaeHemolysisHumansMolecular StructureMonoterpenesOleanolic AcidPlant RootsPlants, MedicinalRabbitsSaponinsTriterpenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18095653

Citation

Ma, Shuang Gang, et al. "Cytotoxic Triterpenoid Saponins Acylated With Monoterpenic Acid From Pithecellobium Lucidum." Journal of Natural Products, vol. 71, no. 1, 2008, pp. 41-6.
Ma SG, Hu YC, Yu SS, et al. Cytotoxic triterpenoid saponins acylated with monoterpenic acid from Pithecellobium lucidum. J Nat Prod. 2008;71(1):41-6.
Ma, S. G., Hu, Y. C., Yu, S. S., Zhang, Y., Chen, X. G., Liu, J., & Liu, Y. X. (2008). Cytotoxic triterpenoid saponins acylated with monoterpenic acid from Pithecellobium lucidum. Journal of Natural Products, 71(1), 41-6.
Ma SG, et al. Cytotoxic Triterpenoid Saponins Acylated With Monoterpenic Acid From Pithecellobium Lucidum. J Nat Prod. 2008;71(1):41-6. PubMed PMID: 18095653.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytotoxic triterpenoid saponins acylated with monoterpenic acid from Pithecellobium lucidum. AU - Ma,Shuang Gang, AU - Hu,You Cai, AU - Yu,Shi Shan, AU - Zhang,Yi, AU - Chen,Xiao Guang, AU - Liu,Jing, AU - Liu,Yu Xi, Y1 - 2007/12/21/ PY - 2007/12/22/pubmed PY - 2008/4/3/medline PY - 2007/12/22/entrez SP - 41 EP - 6 JF - Journal of natural products JO - J Nat Prod VL - 71 IS - 1 N2 - Three new oleanane-type triterpene saponins, named pithelucosides A-C (1-3), together with two known saponins (4, 5) were isolated from the roots of Pithecellobium lucidum. The structures of the new saponins were established on the basis of extensive 1D and 2D NMR experiments and mass spectrometry and confirmed by acid and alkaline hydrolysis. Compounds 1-5 and 7 (pro-sapogenin obtained from the mild alkaline hydrolysate of 1) were evaluated for cytotoxic activity on five human tumoral cell lines (HCT-8, Bel-7402, BGC-823, A549, and A2780) and for hemolytic property against rabbit erythrocytes. Compounds 2-5 showed significant cytotoxic activities with IC50 values of 0.61-7.56 microM. All tested compounds did not exhibit any hemolytic activity in the concentration range 0.01-100 microM. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/18095653/Cytotoxic_triterpenoid_saponins_acylated_with_monoterpenic_acid_from_Pithecellobium_lucidum_ DB - PRIME DP - Unbound Medicine ER -