Tags

Type your tag names separated by a space and hit enter

Oral nabilone capsules in the treatment of chemotherapy-induced nausea and vomiting and pain.

Abstract

BACKGROUND

Nabilone has been approved to treat chemotherapy-induced nausea and vomiting. Recent studies have explored cannabinoids in pain management.

OBJECTIVES

To review the evidence for the use of cannabinoids in general and nabilone in particular; i) in managing chemotherapy-induced nausea and vomiting; and ii) in treating pain.

METHOD

A systematic review of published English literature used the terms: cancer, cannabinoid, nabilone, nausea, pain, tetrahydrocannabinol and vomiting as search terms. Reviews, meta-analyses and treatment trials were reviewed.

RESULTS/CONCLUSIONS

Nabilone is superior to placebo, domperidone and prochlorperazine but not metoclopramide or chlorpromazine. Cannabinoids do not add to benefits of 5-HT(3) receptor antagonists. Side effects are greater for nabilone than for prochlorperazine, in most studies patients prefered nabilone over prochlorperazine. Nabilone is ineffective in acute pain but benefits in neuropathic pain and central hypersensitization. Recent guidelines place nabilone as a second to fourth line drug for neuropathic pain.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    Director of Research The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, R35, Cleveland OH 44195, USA. davism6@ccf.org

    Source

    MeSH

    Administration, Oral
    Analgesics, Non-Narcotic
    Antiemetics
    Antineoplastic Agents
    Clinical Trials as Topic
    Dronabinol
    Humans
    Nausea
    Pain
    Treatment Outcome
    Vomiting

    Pub Type(s)

    Journal Article
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    18095921

    Citation

    Davis, Mellar P.. "Oral Nabilone Capsules in the Treatment of Chemotherapy-induced Nausea and Vomiting and Pain." Expert Opinion On Investigational Drugs, vol. 17, no. 1, 2008, pp. 85-95.
    Davis MP. Oral nabilone capsules in the treatment of chemotherapy-induced nausea and vomiting and pain. Expert Opin Investig Drugs. 2008;17(1):85-95.
    Davis, M. P. (2008). Oral nabilone capsules in the treatment of chemotherapy-induced nausea and vomiting and pain. Expert Opinion On Investigational Drugs, 17(1), pp. 85-95.
    Davis MP. Oral Nabilone Capsules in the Treatment of Chemotherapy-induced Nausea and Vomiting and Pain. Expert Opin Investig Drugs. 2008;17(1):85-95. PubMed PMID: 18095921.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Oral nabilone capsules in the treatment of chemotherapy-induced nausea and vomiting and pain. A1 - Davis,Mellar P, PY - 2007/12/22/pubmed PY - 2008/2/9/medline PY - 2007/12/22/entrez SP - 85 EP - 95 JF - Expert opinion on investigational drugs JO - Expert Opin Investig Drugs VL - 17 IS - 1 N2 - BACKGROUND: Nabilone has been approved to treat chemotherapy-induced nausea and vomiting. Recent studies have explored cannabinoids in pain management. OBJECTIVES: To review the evidence for the use of cannabinoids in general and nabilone in particular; i) in managing chemotherapy-induced nausea and vomiting; and ii) in treating pain. METHOD: A systematic review of published English literature used the terms: cancer, cannabinoid, nabilone, nausea, pain, tetrahydrocannabinol and vomiting as search terms. Reviews, meta-analyses and treatment trials were reviewed. RESULTS/CONCLUSIONS: Nabilone is superior to placebo, domperidone and prochlorperazine but not metoclopramide or chlorpromazine. Cannabinoids do not add to benefits of 5-HT(3) receptor antagonists. Side effects are greater for nabilone than for prochlorperazine, in most studies patients prefered nabilone over prochlorperazine. Nabilone is ineffective in acute pain but benefits in neuropathic pain and central hypersensitization. Recent guidelines place nabilone as a second to fourth line drug for neuropathic pain. SN - 1744-7658 UR - https://www.unboundmedicine.com/medline/citation/18095921/Oral_nabilone_capsules_in_the_treatment_of_chemotherapy_induced_nausea_and_vomiting_and_pain_ L2 - http://www.tandfonline.com/doi/full/10.1517/13543784.17.1.85 DB - PRIME DP - Unbound Medicine ER -