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Inactivation of enveloped viruses by anthraquinones extracted from plants.
Antimicrob Agents Chemother. 1991 Dec; 35(12):2463-6.AA

Abstract

To determine the extent of antiviral activity present in a number of plant extracts, hot glycerin extracts were prepared from Rheum officinale, Aloe barbadensis, Rhamnus frangula, Rhamnus purshianus, and Cassia angustifolia and their virucidal effects were tested against herpes simplex virus type 1. All the plant extracts inactivated the virus. The active components in these plants were separated by thin-layer chromatography and identified as anthraquinones. A purified sample of aloe emodin was prepared from aloin, and its effects on the infectivity of herpes simplex virus type 1 and type 2, varicella-zoster virus, pseudorabies virus, influenza virus, adenovirus, and rhinovirus were tested by mixing virus with dilutions of aloe emodin for 15 min at 37 degrees C, immediately diluting the sample, and assaying the amount of infectious virus remaining in the sample. The results showed that aloe emodin inactivated all of the viruses tested except adenovirus and rhinovirus. Electron microscopic examination of anthraquinone-treated herpes simplex virus demonstrated that the envelopes were partially disrupted. These results show that anthraquinones extracted from a variety of plants are directly virucidal to enveloped viruses.

Authors+Show Affiliations

Department of Microbiology, University of Maryland, Baltimore 21201.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1810179

Citation

Sydiskis, R J., et al. "Inactivation of Enveloped Viruses By Anthraquinones Extracted From Plants." Antimicrobial Agents and Chemotherapy, vol. 35, no. 12, 1991, pp. 2463-6.
Sydiskis RJ, Owen DG, Lohr JL, et al. Inactivation of enveloped viruses by anthraquinones extracted from plants. Antimicrob Agents Chemother. 1991;35(12):2463-6.
Sydiskis, R. J., Owen, D. G., Lohr, J. L., Rosler, K. H., & Blomster, R. N. (1991). Inactivation of enveloped viruses by anthraquinones extracted from plants. Antimicrobial Agents and Chemotherapy, 35(12), 2463-6.
Sydiskis RJ, et al. Inactivation of Enveloped Viruses By Anthraquinones Extracted From Plants. Antimicrob Agents Chemother. 1991;35(12):2463-6. PubMed PMID: 1810179.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inactivation of enveloped viruses by anthraquinones extracted from plants. AU - Sydiskis,R J, AU - Owen,D G, AU - Lohr,J L, AU - Rosler,K H, AU - Blomster,R N, PY - 1991/12/1/pubmed PY - 1991/12/1/medline PY - 1991/12/1/entrez SP - 2463 EP - 6 JF - Antimicrobial agents and chemotherapy JO - Antimicrob Agents Chemother VL - 35 IS - 12 N2 - To determine the extent of antiviral activity present in a number of plant extracts, hot glycerin extracts were prepared from Rheum officinale, Aloe barbadensis, Rhamnus frangula, Rhamnus purshianus, and Cassia angustifolia and their virucidal effects were tested against herpes simplex virus type 1. All the plant extracts inactivated the virus. The active components in these plants were separated by thin-layer chromatography and identified as anthraquinones. A purified sample of aloe emodin was prepared from aloin, and its effects on the infectivity of herpes simplex virus type 1 and type 2, varicella-zoster virus, pseudorabies virus, influenza virus, adenovirus, and rhinovirus were tested by mixing virus with dilutions of aloe emodin for 15 min at 37 degrees C, immediately diluting the sample, and assaying the amount of infectious virus remaining in the sample. The results showed that aloe emodin inactivated all of the viruses tested except adenovirus and rhinovirus. Electron microscopic examination of anthraquinone-treated herpes simplex virus demonstrated that the envelopes were partially disrupted. These results show that anthraquinones extracted from a variety of plants are directly virucidal to enveloped viruses. SN - 0066-4804 UR - https://www.unboundmedicine.com/medline/citation/1810179/Inactivation_of_enveloped_viruses_by_anthraquinones_extracted_from_plants_ L2 - http://aac.asm.org/cgi/pmidlookup?view=long&pmid=1810179 DB - PRIME DP - Unbound Medicine ER -