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Biodegradable chitosan matrix for the controlled release of steroids.

Abstract

Chitosan, a polysaccharide, having structural characteristics similar to glycosaminoglycans, seems to be nontoxic and bioabsorbable. This study highlights the use of chitosan matrix for controlled drug delivery systems. The steroid drugs, namely testosterone, progesterone and beta-oestradiol were mixed with chitosan and the films were prepared by evaporation technique. The in vitro release profile of these steroids from the film matrix was monitored, as a function of time, in phosphate buffered saline (PBS, pH 7.4) at 37 degree C using a U-V-spectrophotometer. The degradation, of these chitosan and drug loaded chitosan films, was also investigated by weight loss and tensile strength studies. The steroid release from chitosan films was compared with the release of these drugs from their microbeads. It appears, the films and the microbeads stayed intact during the dissolution study of 90 days and the possibility of using these systems in contraceptive applications and novel drug delivery systems are discussed.

Authors+Show Affiliations

Biosurface Technology Division, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

1810408

Citation

Chandy, T, and C P. Sharma. "Biodegradable Chitosan Matrix for the Controlled Release of Steroids." Biomaterials, Artificial Cells, and Immobilization Biotechnology : Official Journal of the International Society for Artificial Cells and Immobilization Biotechnology, vol. 19, no. 4, 1991, pp. 745-60.
Chandy T, Sharma CP. Biodegradable chitosan matrix for the controlled release of steroids. Biomater Artif Cells Immobilization Biotechnol. 1991;19(4):745-60.
Chandy, T., & Sharma, C. P. (1991). Biodegradable chitosan matrix for the controlled release of steroids. Biomaterials, Artificial Cells, and Immobilization Biotechnology : Official Journal of the International Society for Artificial Cells and Immobilization Biotechnology, 19(4), 745-60.
Chandy T, Sharma CP. Biodegradable Chitosan Matrix for the Controlled Release of Steroids. Biomater Artif Cells Immobilization Biotechnol. 1991;19(4):745-60. PubMed PMID: 1810408.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biodegradable chitosan matrix for the controlled release of steroids. AU - Chandy,T, AU - Sharma,C P, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 745 EP - 60 JF - Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology JO - Biomater Artif Cells Immobilization Biotechnol VL - 19 IS - 4 N2 - Chitosan, a polysaccharide, having structural characteristics similar to glycosaminoglycans, seems to be nontoxic and bioabsorbable. This study highlights the use of chitosan matrix for controlled drug delivery systems. The steroid drugs, namely testosterone, progesterone and beta-oestradiol were mixed with chitosan and the films were prepared by evaporation technique. The in vitro release profile of these steroids from the film matrix was monitored, as a function of time, in phosphate buffered saline (PBS, pH 7.4) at 37 degree C using a U-V-spectrophotometer. The degradation, of these chitosan and drug loaded chitosan films, was also investigated by weight loss and tensile strength studies. The steroid release from chitosan films was compared with the release of these drugs from their microbeads. It appears, the films and the microbeads stayed intact during the dissolution study of 90 days and the possibility of using these systems in contraceptive applications and novel drug delivery systems are discussed. SN - 1055-7172 UR - https://www.unboundmedicine.com/medline/citation/1810408/Biodegradable_chitosan_matrix_for_the_controlled_release_of_steroids_ L2 - https://www.lens.org/lens/search?q=citation_id:1810408 DB - PRIME DP - Unbound Medicine ER -