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[Effect of a controlled low-protein diet on the pharmacological response to levodopa and on the plasma levels of L-dopa and amino acids in patients with Parkinson's disease].
Arch Neurobiol (Madr). 1991 Nov-Dec; 54(6):296-302.AN

Abstract

Levodopa is the treatment of choice in Parkinson's disease, but a high percentage of patients develop complications in the response, including fluctuations, after some years of treatment. Although the origin of fluctuations is unknown, these could be, at least partly, attributed to pharmacokinetic factors. Aromatic aminoacids interfere in the absorption and brain penetration of levodopa, and lowering protein intake improves the quality of the response. The continuation of a low-protein diet is difficult for some patients. In this way, to know if these diet effects are noticeable in an acute period would be interesting, in order to select groups of patients who were susceptible to improve with this treatment. In this report we have studied the acute effect of a low protein diet on the pharmacological response to levodopa, and the plasmatic levels of L-Dopa, 3-OM-Dopa and large neutral aminoacids. Protein restriction improves clinical response to levodopa, although the mechanisms of this improvement remain unknown.

Authors+Show Affiliations

Servicio de Neurología, Fundación Jiménez Díaz, Madrid.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

spa

PubMed ID

1811460

Citation

Sanchís, G, et al. "[Effect of a Controlled Low-protein Diet On the Pharmacological Response to Levodopa and On the Plasma Levels of L-dopa and Amino Acids in Patients With Parkinson's Disease]." Archivos De Neurobiologia, vol. 54, no. 6, 1991, pp. 296-302.
Sanchís G, Mena MA, Martín del Río R, et al. [Effect of a controlled low-protein diet on the pharmacological response to levodopa and on the plasma levels of L-dopa and amino acids in patients with Parkinson's disease]. Arch Neurobiol (Madr). 1991;54(6):296-302.
Sanchís, G., Mena, M. A., Martín del Río, R., Morales, B., Casarejo, M. J., de Yébenes, M. J., Tabernero, C., Jiménez, A., & de Yébenes, J. G. (1991). [Effect of a controlled low-protein diet on the pharmacological response to levodopa and on the plasma levels of L-dopa and amino acids in patients with Parkinson's disease]. Archivos De Neurobiologia, 54(6), 296-302.
Sanchís G, et al. [Effect of a Controlled Low-protein Diet On the Pharmacological Response to Levodopa and On the Plasma Levels of L-dopa and Amino Acids in Patients With Parkinson's Disease]. Arch Neurobiol (Madr). 1991 Nov-Dec;54(6):296-302. PubMed PMID: 1811460.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of a controlled low-protein diet on the pharmacological response to levodopa and on the plasma levels of L-dopa and amino acids in patients with Parkinson's disease]. AU - Sanchís,G, AU - Mena,M A, AU - Martín del Río,R, AU - Morales,B, AU - Casarejo,M J, AU - de Yébenes,M J, AU - Tabernero,C, AU - Jiménez,A, AU - de Yébenes,J G, PY - 1991/11/1/pubmed PY - 1991/11/1/medline PY - 1991/11/1/entrez SP - 296 EP - 302 JF - Archivos de neurobiologia JO - Arch Neurobiol (Madr) VL - 54 IS - 6 N2 - Levodopa is the treatment of choice in Parkinson's disease, but a high percentage of patients develop complications in the response, including fluctuations, after some years of treatment. Although the origin of fluctuations is unknown, these could be, at least partly, attributed to pharmacokinetic factors. Aromatic aminoacids interfere in the absorption and brain penetration of levodopa, and lowering protein intake improves the quality of the response. The continuation of a low-protein diet is difficult for some patients. In this way, to know if these diet effects are noticeable in an acute period would be interesting, in order to select groups of patients who were susceptible to improve with this treatment. In this report we have studied the acute effect of a low protein diet on the pharmacological response to levodopa, and the plasmatic levels of L-Dopa, 3-OM-Dopa and large neutral aminoacids. Protein restriction improves clinical response to levodopa, although the mechanisms of this improvement remain unknown. SN - 0004-0576 UR - https://www.unboundmedicine.com/medline/citation/1811460/[Effect_of_a_controlled_low_protein_diet_on_the_pharmacological_response_to_levodopa_and_on_the_plasma_levels_of_L_dopa_and_amino_acids_in_patients_with_Parkinson's_disease]_ L2 - https://medlineplus.gov/parkinsonsdisease.html DB - PRIME DP - Unbound Medicine ER -