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[Status epilepticus in chronically dialyzed patients treated with erythropoietin].
Riv Neurol. 1991 Nov-Dec; 61(6):215-8.RN

Abstract

This paper describes the clinical features of two patients with chronic renal failure and uremic anaemia treated with recombinant human erythropoietin (9000 I.U. subcutaneously subdivided in 3 times weekly at the end of haemodialysis treatment) who developed seizures and status epilepticus. This treatment has unequivocal benefits but in some patients has been accompanied by elevated blood pressure leading to hypertensive encephalopathy with seizures. In fact, the correction of the anaemia results in a rise in packed cell volume with a consequent increase in blood viscosity, predisposing to increased vascular resistance and the development of hypertension.

Authors+Show Affiliations

Massetani R
Cattedra di Neurofisiopatologia, Università di Pisa.
Galli R
No affiliation info available
Calabrese R
No affiliation info available
Sartucci F
No affiliation info available
Rindi P
No affiliation info available
Severino Brandi L
No affiliation info available
Murri L
No affiliation info available

MeSH

AdultAnemiaBlood ViscosityBrain IschemiaErythropoietinFemaleHumansHypertensionKidney Failure, ChronicMaleRecombinant ProteinsRenal DialysisStatus EpilepticusVasoconstriction

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

ita

PubMed ID

1813973

Citation

Massetani, R, et al. "[Status Epilepticus in Chronically Dialyzed Patients Treated With Erythropoietin]." Rivista Di Neurologia, vol. 61, no. 6, 1991, pp. 215-8.
Massetani R, Galli R, Calabrese R, et al. [Status epilepticus in chronically dialyzed patients treated with erythropoietin]. Riv Neurol. 1991;61(6):215-8.
Massetani, R., Galli, R., Calabrese, R., Sartucci, F., Rindi, P., Severino Brandi, L., & Murri, L. (1991). [Status epilepticus in chronically dialyzed patients treated with erythropoietin]. Rivista Di Neurologia, 61(6), 215-8.
Massetani R, et al. [Status Epilepticus in Chronically Dialyzed Patients Treated With Erythropoietin]. Riv Neurol. 1991 Nov-Dec;61(6):215-8. PubMed PMID: 1813973.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Status epilepticus in chronically dialyzed patients treated with erythropoietin]. AU - Massetani,R, AU - Galli,R, AU - Calabrese,R, AU - Sartucci,F, AU - Rindi,P, AU - Severino Brandi,L, AU - Murri,L, PY - 1991/11/1/pubmed PY - 1991/11/1/medline PY - 1991/11/1/entrez SP - 215 EP - 8 JF - Rivista di neurologia JO - Riv Neurol VL - 61 IS - 6 N2 - This paper describes the clinical features of two patients with chronic renal failure and uremic anaemia treated with recombinant human erythropoietin (9000 I.U. subcutaneously subdivided in 3 times weekly at the end of haemodialysis treatment) who developed seizures and status epilepticus. This treatment has unequivocal benefits but in some patients has been accompanied by elevated blood pressure leading to hypertensive encephalopathy with seizures. In fact, the correction of the anaemia results in a rise in packed cell volume with a consequent increase in blood viscosity, predisposing to increased vascular resistance and the development of hypertension. SN - 0035-6344 UR - https://www.unboundmedicine.com/medline/citation/1813973/[Status_epilepticus_in_chronically_dialyzed_patients_treated_with_erythropoietin]_ DB - PRIME DP - Unbound Medicine ER -