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[Bronchial reactivity after provocation of the nasal mucosa with histamine].
Arh Hig Rada Toksikol 1991; 42(4):341-8AH

Abstract

Data on the relationship between nasal and bronchial reactivities are scarce. This study aimed at investigating a possible influence of the nasal provocation test on bronchial reactivity. Three groups of eleven subjects each were examined: patients suffering from allergic rhinitis with no clinical evidence of asthma, workers exposed to respiratory irritants complaining of occupational rhinitis and asthma, and healthy subjects. Non-specific bronchoprovocation was performed before and after nasal challenge with histamine. The bronchial challenge with histamine solutions (0.125 mg/ml and 128 mg/ml) was performed by the five-breath cumulative method (Chai H. et al. J Allergy Clin Immunol 1975;56:323-7). Non-specific nasal provocation was performed by spraying doubling concentrations of histamine (0.125 mg/ml-32 mg/ml) into both nostrils at three-minute intervals. The reaction was monitored by measurement of nasal inspiratory peak flow, nasal resistance, and nasal spirometry. The level of non-specific nasal reactivity was significantly lower in patients with allergic rhinitis than in the other two groups. The bronchial reactivity of the "rhinitis" group and of those occupationally exposed to irritants was significantly lower than among healthy subjects. An immediate and significant decrease in bronchial reactivity could be observed after nasal challenge in the group of healthy subjects as well as in workers exposed to irritants, but there was no significant change in bronchial reactivity among patients suffering from allergic rhinitis.

Authors+Show Affiliations

Institut za medicinska istrazivanja i medicinu rada Sveucilista u Zagrebu.No affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

hrv

PubMed ID

1815488

Citation

Somogyi-Zalud, E, and J Godnić-Cvar. "[Bronchial Reactivity After Provocation of the Nasal Mucosa With Histamine]." Arhiv Za Higijenu Rada I Toksikologiju, vol. 42, no. 4, 1991, pp. 341-8.
Somogyi-Zalud E, Godnić-Cvar J. [Bronchial reactivity after provocation of the nasal mucosa with histamine]. Arh Hig Rada Toksikol. 1991;42(4):341-8.
Somogyi-Zalud, E., & Godnić-Cvar, J. (1991). [Bronchial reactivity after provocation of the nasal mucosa with histamine]. Arhiv Za Higijenu Rada I Toksikologiju, 42(4), pp. 341-8.
Somogyi-Zalud E, Godnić-Cvar J. [Bronchial Reactivity After Provocation of the Nasal Mucosa With Histamine]. Arh Hig Rada Toksikol. 1991;42(4):341-8. PubMed PMID: 1815488.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Bronchial reactivity after provocation of the nasal mucosa with histamine]. AU - Somogyi-Zalud,E, AU - Godnić-Cvar,J, PY - 1991/12/1/pubmed PY - 1991/12/1/medline PY - 1991/12/1/entrez SP - 341 EP - 8 JF - Arhiv za higijenu rada i toksikologiju JO - Arh Hig Rada Toksikol VL - 42 IS - 4 N2 - Data on the relationship between nasal and bronchial reactivities are scarce. This study aimed at investigating a possible influence of the nasal provocation test on bronchial reactivity. Three groups of eleven subjects each were examined: patients suffering from allergic rhinitis with no clinical evidence of asthma, workers exposed to respiratory irritants complaining of occupational rhinitis and asthma, and healthy subjects. Non-specific bronchoprovocation was performed before and after nasal challenge with histamine. The bronchial challenge with histamine solutions (0.125 mg/ml and 128 mg/ml) was performed by the five-breath cumulative method (Chai H. et al. J Allergy Clin Immunol 1975;56:323-7). Non-specific nasal provocation was performed by spraying doubling concentrations of histamine (0.125 mg/ml-32 mg/ml) into both nostrils at three-minute intervals. The reaction was monitored by measurement of nasal inspiratory peak flow, nasal resistance, and nasal spirometry. The level of non-specific nasal reactivity was significantly lower in patients with allergic rhinitis than in the other two groups. The bronchial reactivity of the "rhinitis" group and of those occupationally exposed to irritants was significantly lower than among healthy subjects. An immediate and significant decrease in bronchial reactivity could be observed after nasal challenge in the group of healthy subjects as well as in workers exposed to irritants, but there was no significant change in bronchial reactivity among patients suffering from allergic rhinitis. SN - 0004-1254 UR - https://www.unboundmedicine.com/medline/citation/1815488/[Bronchial_reactivity_after_provocation_of_the_nasal_mucosa_with_histamine]_ DB - PRIME DP - Unbound Medicine ER -