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A comparison of aerobic exercise and resistance training in patients with and without chronic kidney disease.
Adv Chronic Kidney Dis. 2008 Jan; 15(1):83-96.AC

Abstract

The morbidity and mortality associated with chronic kidney disease (CKD) are primarily caused by atherosclerosis and cardiovascular disease, which may be in part caused by inflammation and oxidative stress. Aerobic exercise and resistance training have been proposed as measures to combat obesity, inflammation, endothelial dysfunction, oxidative stress, insulin resistance, and progression of CKD. In non-CKD patients, aerobic exercise reduces inflammation, increases insulin sensitivity, decreases microalbuminuria, facilitates weight loss, decreases leptins, and protects against oxidative injury. In nondialysis CKD, aerobic exercise decreases microalbuminuria, protects from oxidative stress, and may increase the glomerular filtration rate (GFR). Aerobic exercise in hemodialysis patients has been reported to enhance insulin sensitivity, improve lipid profile, increase hemoglobin, increase strength, decrease blood pressure, and improve quality of life. Resistance training, in the general population, decreases C-reactive protein, increases insulin sensitivity, decreases body fat content, increases insulin-like growth factor-1 (IGF-1), and decreases microalbuminuria. In the nondialysis CKD population, resistance training has been reported to reduce inflammation, increase serum albumin, maintain body weight, increase muscle strength, increase IGF-1, and increase GFR. Resistance training in hemodialysis increases muscle strength, increases physical functionality, and improves IGF-1 status. Combined aerobic exercise and resistance training during dialysis improves muscle strength, work output, cardiac fitness, and possibly dialysis adequacy. There is a need for more investigation on the role of exercise in CKD. If the benefits of aerobic exercise and strength training in non-CKD populations can be shown to apply to CKD patients as well, renal rehabilitation will begin to play an important role in the approach to the treatment, prevention, and slowed progression of CKD.

Authors+Show Affiliations

Department of Medicine, Loyola University Medical Center, Maywood, IL 60153, USA.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Review

Language

eng

PubMed ID

18155113

Citation

Moinuddin, Irfan, and David J. Leehey. "A Comparison of Aerobic Exercise and Resistance Training in Patients With and Without Chronic Kidney Disease." Advances in Chronic Kidney Disease, vol. 15, no. 1, 2008, pp. 83-96.
Moinuddin I, Leehey DJ. A comparison of aerobic exercise and resistance training in patients with and without chronic kidney disease. Adv Chronic Kidney Dis. 2008;15(1):83-96.
Moinuddin, I., & Leehey, D. J. (2008). A comparison of aerobic exercise and resistance training in patients with and without chronic kidney disease. Advances in Chronic Kidney Disease, 15(1), 83-96.
Moinuddin I, Leehey DJ. A Comparison of Aerobic Exercise and Resistance Training in Patients With and Without Chronic Kidney Disease. Adv Chronic Kidney Dis. 2008;15(1):83-96. PubMed PMID: 18155113.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison of aerobic exercise and resistance training in patients with and without chronic kidney disease. AU - Moinuddin,Irfan, AU - Leehey,David J, PY - 2007/12/25/pubmed PY - 2008/1/16/medline PY - 2007/12/25/entrez SP - 83 EP - 96 JF - Advances in chronic kidney disease JO - Adv Chronic Kidney Dis VL - 15 IS - 1 N2 - The morbidity and mortality associated with chronic kidney disease (CKD) are primarily caused by atherosclerosis and cardiovascular disease, which may be in part caused by inflammation and oxidative stress. Aerobic exercise and resistance training have been proposed as measures to combat obesity, inflammation, endothelial dysfunction, oxidative stress, insulin resistance, and progression of CKD. In non-CKD patients, aerobic exercise reduces inflammation, increases insulin sensitivity, decreases microalbuminuria, facilitates weight loss, decreases leptins, and protects against oxidative injury. In nondialysis CKD, aerobic exercise decreases microalbuminuria, protects from oxidative stress, and may increase the glomerular filtration rate (GFR). Aerobic exercise in hemodialysis patients has been reported to enhance insulin sensitivity, improve lipid profile, increase hemoglobin, increase strength, decrease blood pressure, and improve quality of life. Resistance training, in the general population, decreases C-reactive protein, increases insulin sensitivity, decreases body fat content, increases insulin-like growth factor-1 (IGF-1), and decreases microalbuminuria. In the nondialysis CKD population, resistance training has been reported to reduce inflammation, increase serum albumin, maintain body weight, increase muscle strength, increase IGF-1, and increase GFR. Resistance training in hemodialysis increases muscle strength, increases physical functionality, and improves IGF-1 status. Combined aerobic exercise and resistance training during dialysis improves muscle strength, work output, cardiac fitness, and possibly dialysis adequacy. There is a need for more investigation on the role of exercise in CKD. If the benefits of aerobic exercise and strength training in non-CKD populations can be shown to apply to CKD patients as well, renal rehabilitation will begin to play an important role in the approach to the treatment, prevention, and slowed progression of CKD. SN - 1548-5609 UR - https://www.unboundmedicine.com/medline/citation/18155113/A_comparison_of_aerobic_exercise_and_resistance_training_in_patients_with_and_without_chronic_kidney_disease_ DB - PRIME DP - Unbound Medicine ER -