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Antinociceptive and anti-inflammatory activities of ethanolic extracts of Lychnophora species.
J Ethnopharmacol. 2008 Feb 28; 116(1):120-4.JE

Abstract

Extracts from Lychnophora species are traditionally used in Brazil as anti-inflammatory, and to treat bruise, pain and rheumatism. The ethanolic extract of aerial parts of five species of Lychnophoras and one specie of Lychnophoriopsis were examined for the antinociceptive (hot-plate and writhing tests) and anti-inflammatory (carrageenan-induced paw oedema test) activity in mice, by oral and topical routes, respectively. In the hot-plate test, the Lychnophora pinaster (0.75 g/kg) and Lychnophora ericoides (1.50 g/kg) extracts significantly increased the time for licking of the paws. The species Lychnophora passerina, Lychnophoriopsis candelabrum and Lychnophora pinaster, using the dose of 0.75 g/kg, and Lychnophora ericoides and Lychnophora trichocarpha in both doses evaluated (0.75 and 1.50 g/kg) significantly reduced the number of writhes induced by acetic acid. The administration of Lychnophora pinaster and Lychnophora trichocarpha ointments, in both concentrations evaluated (5 and 10%, w/w), and Lychnophora passerina and Lychnophoriopsis candelabrum, in the concentration of 10%, significantly reduced the paw oedema measured 3 h after carrageenan administration, suggesting, for the first time, an anti-inflammatory activity upon topical administration of these species. The present work comparatively demonstrated the antinociceptive and anti-inflammatory activities of some Brazilian Lychnophoras.

Authors+Show Affiliations

Laboratório de Farmacologia Experimental, Escola de Farmácia, Universidade Federal de Ouro Preto, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18155374

Citation

Guzzo, L S., et al. "Antinociceptive and Anti-inflammatory Activities of Ethanolic Extracts of Lychnophora Species." Journal of Ethnopharmacology, vol. 116, no. 1, 2008, pp. 120-4.
Guzzo LS, Saúde-Guimarães DA, Silva AC, et al. Antinociceptive and anti-inflammatory activities of ethanolic extracts of Lychnophora species. J Ethnopharmacol. 2008;116(1):120-4.
Guzzo, L. S., Saúde-Guimarães, D. A., Silva, A. C., Lombardi, J. A., Guimarães, H. N., & Grabe-Guimarães, A. (2008). Antinociceptive and anti-inflammatory activities of ethanolic extracts of Lychnophora species. Journal of Ethnopharmacology, 116(1), 120-4.
Guzzo LS, et al. Antinociceptive and Anti-inflammatory Activities of Ethanolic Extracts of Lychnophora Species. J Ethnopharmacol. 2008 Feb 28;116(1):120-4. PubMed PMID: 18155374.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antinociceptive and anti-inflammatory activities of ethanolic extracts of Lychnophora species. AU - Guzzo,L S, AU - Saúde-Guimarães,D A, AU - Silva,A C A, AU - Lombardi,J A, AU - Guimarães,H N, AU - Grabe-Guimarães,A, Y1 - 2007/11/17/ PY - 2007/03/08/received PY - 2007/11/06/revised PY - 2007/11/09/accepted PY - 2007/12/25/pubmed PY - 2008/5/2/medline PY - 2007/12/25/entrez SP - 120 EP - 4 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 116 IS - 1 N2 - Extracts from Lychnophora species are traditionally used in Brazil as anti-inflammatory, and to treat bruise, pain and rheumatism. The ethanolic extract of aerial parts of five species of Lychnophoras and one specie of Lychnophoriopsis were examined for the antinociceptive (hot-plate and writhing tests) and anti-inflammatory (carrageenan-induced paw oedema test) activity in mice, by oral and topical routes, respectively. In the hot-plate test, the Lychnophora pinaster (0.75 g/kg) and Lychnophora ericoides (1.50 g/kg) extracts significantly increased the time for licking of the paws. The species Lychnophora passerina, Lychnophoriopsis candelabrum and Lychnophora pinaster, using the dose of 0.75 g/kg, and Lychnophora ericoides and Lychnophora trichocarpha in both doses evaluated (0.75 and 1.50 g/kg) significantly reduced the number of writhes induced by acetic acid. The administration of Lychnophora pinaster and Lychnophora trichocarpha ointments, in both concentrations evaluated (5 and 10%, w/w), and Lychnophora passerina and Lychnophoriopsis candelabrum, in the concentration of 10%, significantly reduced the paw oedema measured 3 h after carrageenan administration, suggesting, for the first time, an anti-inflammatory activity upon topical administration of these species. The present work comparatively demonstrated the antinociceptive and anti-inflammatory activities of some Brazilian Lychnophoras. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/18155374/Antinociceptive_and_anti_inflammatory_activities_of_ethanolic_extracts_of_Lychnophora_species_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(07)00597-1 DB - PRIME DP - Unbound Medicine ER -