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The effects of physiological and pharmacological weight loss on adiponectin and leptin mRNA levels in the rat epididymal adipose tissue.
Eur J Pharmacol 2008; 579(1-3):433-8EJ

Abstract

In subjects with obesity, diabetes and coronary artery disease, circulating levels of leptin increased while that of adiponectin is decreased. In this study we have investigated effects of physiological and pharmacological weight reduction on leptin and adiponectin mRNA expression. Wistar rats were fed either standard laboratory chow for 16 weeks (chow-fed) or given a fat-enriched, glucose-enriched diet (diet-fed) for 8 weeks. After 8 weeks, diet-fed group was subdivided into three subgroups, namely, an untreated obese, or were returned to chow diet, or treated with fenofibrate for further 8 week. After 16 weeks, compared with chow-fed group, diet-fed rats had significantly higher body weight, epididymal fat pad mass, and plasma levels of insulin, leptin, adiponectin, non-esterified fatty acids and triglycerides (P<0.001, for all). Moreover, untreated obese rats had significantly (P<0.01, for both) raised levels of Ob mRNA but reduced adiponectin mRNA levels in epididymal fat pads compared with chow-fed group. These changes were corrected by chronic removal of the high-energy diet and fenofibrate treatment. These findings indicate that physiological or pharmacological lowering of body weight together with circulating plasma lipids play a significant role in leptin and adiponectin synthesis and metabolism.

Authors+Show Affiliations

Neuroendocrine & Obesity Biology Unit, School of Clinical Sciences, University of Liverpool, Daluby Street, Liverpool L69 3GA, UK. naderali@liverpool.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18155694

Citation

Naderali, Ebrahim K., et al. "The Effects of Physiological and Pharmacological Weight Loss On Adiponectin and Leptin mRNA Levels in the Rat Epididymal Adipose Tissue." European Journal of Pharmacology, vol. 579, no. 1-3, 2008, pp. 433-8.
Naderali EK, Fatani S, Telles M, et al. The effects of physiological and pharmacological weight loss on adiponectin and leptin mRNA levels in the rat epididymal adipose tissue. Eur J Pharmacol. 2008;579(1-3):433-8.
Naderali, E. K., Fatani, S., Telles, M., & Hunter, L. (2008). The effects of physiological and pharmacological weight loss on adiponectin and leptin mRNA levels in the rat epididymal adipose tissue. European Journal of Pharmacology, 579(1-3), pp. 433-8.
Naderali EK, et al. The Effects of Physiological and Pharmacological Weight Loss On Adiponectin and Leptin mRNA Levels in the Rat Epididymal Adipose Tissue. Eur J Pharmacol. 2008 Jan 28;579(1-3):433-8. PubMed PMID: 18155694.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of physiological and pharmacological weight loss on adiponectin and leptin mRNA levels in the rat epididymal adipose tissue. AU - Naderali,Ebrahim K, AU - Fatani,Sameer, AU - Telles,Monica, AU - Hunter,Leif, Y1 - 2007/11/23/ PY - 2007/06/12/received PY - 2007/10/29/revised PY - 2007/11/10/accepted PY - 2007/12/25/pubmed PY - 2008/4/16/medline PY - 2007/12/25/entrez SP - 433 EP - 8 JF - European journal of pharmacology JO - Eur. J. Pharmacol. VL - 579 IS - 1-3 N2 - In subjects with obesity, diabetes and coronary artery disease, circulating levels of leptin increased while that of adiponectin is decreased. In this study we have investigated effects of physiological and pharmacological weight reduction on leptin and adiponectin mRNA expression. Wistar rats were fed either standard laboratory chow for 16 weeks (chow-fed) or given a fat-enriched, glucose-enriched diet (diet-fed) for 8 weeks. After 8 weeks, diet-fed group was subdivided into three subgroups, namely, an untreated obese, or were returned to chow diet, or treated with fenofibrate for further 8 week. After 16 weeks, compared with chow-fed group, diet-fed rats had significantly higher body weight, epididymal fat pad mass, and plasma levels of insulin, leptin, adiponectin, non-esterified fatty acids and triglycerides (P<0.001, for all). Moreover, untreated obese rats had significantly (P<0.01, for both) raised levels of Ob mRNA but reduced adiponectin mRNA levels in epididymal fat pads compared with chow-fed group. These changes were corrected by chronic removal of the high-energy diet and fenofibrate treatment. These findings indicate that physiological or pharmacological lowering of body weight together with circulating plasma lipids play a significant role in leptin and adiponectin synthesis and metabolism. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/18155694/The_effects_of_physiological_and_pharmacological_weight_loss_on_adiponectin_and_leptin_mRNA_levels_in_the_rat_epididymal_adipose_tissue_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(07)01285-X DB - PRIME DP - Unbound Medicine ER -